Ezrin Protein (EZR)
Quick Overview for Ezrin Protein (EZR) (ABIN7319618)
Target
See all Ezrin (EZR) ProteinsProtein Type
Origin
Source
Purity
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Purpose
- Recombinant Human Ezrin/EZR Protein
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Sequence
- Met1-Leu586
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Characteristics
- Recombinant Human Ezrin is produced by our E.coli expression system and the target gene encoding Met1-Leu586 is expressed.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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Ezrin (EZR) (AA 1-586) protein (GST tag)
EZR Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Ezrin (EZR) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)EZR Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Ezrin (EZR) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)EZR Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please refer to the printed manual for detailed information.
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Buffer
- Lyophilized from a 0.2 μm filtered solution of 10 mM Hepes, pH 7.4.
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Ezrin (EZR)
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Alternative Name
- Ezrin/EZR
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Background
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Background: Ezrin is expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. The N-terminus of ezrin contains a FERM domain which is further subdivided into three subdomains. The C-terminus contain a ERM domain. As a member of the ERM protein family, Ezrin serves as an intermediate between the plasma membrane and the actin cytoskeleton. It plays a key role in cell surface structure adhesion, migration, and organization. Ezrin probably involved in connections of major cytoskeletal structures to the plasma membrane. The N-terminal FERM domain strongly binds sodium-hydrogen exchanger regulatory factor (NHERF) proteins (involving long-range allostery). The C-terminal binds to actin, phosphatidylinositol bis-phosphate (PIP2) and membrane proteins like CD44 and ICAM-2. In epithelial cells, Ezrin is required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, Ezrin is required for normal macropinocytosis.
Synonym: Ezrin, Cytovillin, Villin-2, p81, EZR, VIL2
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Molecular Weight
- 69.4 kDa
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UniProt
- P15311
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Pathways
- Maintenance of Protein Location
Target
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