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The protein encoded by FLG is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. Additionally we are shipping Filaggrin Kits (20) and Filaggrin Proteins (5) and many more products for this protein.
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Data suggest that Fgf1 (show FGF1 Antibodies)-mediated signaling represents an important signaling cascade related to adipogenesis and visceral adiposity; expression of Fgf1 (fibroblast growth factor 1 (show FGF1 Antibodies)) and Fgfr1 (fibroblast growth factor receptor 1 (show FGFR1 Antibodies)) is up-regulated in adipose tissue of obese mice (both obese mice due to high-fat diet and obese mice due to genetic deletion of leptin (show LEP Antibodies)).
FGFR1OP2 (show FGFR1OP2 Antibodies)-FGFR1 (show FGFR1 Antibodies) fusion in hematopoietic stem cells induced myeloid leukemia (show BCL11A Antibodies) and T-cell lymphoma in a mouse model.
MiR (show MLXIP Antibodies)-214 was up-regulated in mesenchymal stem cells of osteoporotic mice and down-regulated during osteoblast differentiation of mesenchymal stem cells. FGFR1 (show FGFR1 Antibodies) is a direct target of miR (show MLXIP Antibodies)-214.
demonstrated that Id1 (show ID1 Antibodies) and E2-2 (show TCF4 Antibodies) are critical regulators of EPCs function in vitro. Id1 (show ID1 Antibodies) interacts with E2-2 (show TCF4 Antibodies) and relieves the E2-2 (show TCF4 Antibodies)-mediated repression of FGFR1 (show FGFR1 Antibodies) and VEGFR2 (show KDR Antibodies) expression to modulate EPCs functions
FGF receptor 1-mediated anosmin-1 (show KAL1 Antibodies) activity plays a crucial role in the continuous remodelling of the adult olfactory bulb.
Fgfr1 (show FGFR1 Antibodies) and Fgfr2 (show FGFR2 Antibodies) in the palatal and mandibular mesenchyme have roles in regulating shelf medial wall protrusion and growth of the mandible to coordinate the craniofacial tissue movements that are required for palatal shelf elevation
Data suggest that signal transduction via Fgf23 (show FGF23 Antibodies)/Fgfr1 (show FGFR1 Antibodies) and calcitriol/calcitriol receptor have opposite roles in innate immunity; Fgf23 (show FGF23 Antibodies) suppresses arginase-1 (show ARG1 Antibodies) expression in macrophages; calcitriol stimulates arginase-1 (show ARG1 Antibodies) expression in macrophages.
FGFR1 (show FGFR1 Antibodies) has dual functions to directly regulate proximal and distal tubule phosphate and calcium reabsorption, indicating a physiological role of FGFR1 (show FGFR1 Antibodies) signaling in both phosphate and calcium homeostasis.
Data demonstrate an essential role for FGFR1 (show FGFR1 Antibodies) and FGFR2 (show FGFR2 Antibodies) in endothelial cells for cardiac functional recovery and vascular remodeling following in vivo cardiac ischemia-reperfusion injury, without affecting the cardiac hypertrophic response.
Activation of FGFR1 (show FGFR1 Antibodies) is essential for the high levels of FGF23 (show FGF23 Antibodies) in acute and chronic experimental uremia.
The authors data reveals that the CNV of FLG (show FGFR1 Antibodies) is associated with AD development in Koreans.
Filaggrin Gene Mutation c.3321delA is Associated with Dry Phenotypes of Atopic Dermatitis in the Chinese Han Population
The present study examined the possible relationship between SNPs of FLG (show FGFR1 Antibodies) and chronic idiopathic urticaria (CIU) for the first time, and demonstrated that none of five investigated SNPs (rs2485518, rs3126065, rs2786680, rs3814300, and rs3814299) are correlated with CIU in an Iranian population.
The study revealed 66 FLG (show FGFR1 Antibodies) mutation carriers and demonstrated an association between c.2282del4 deletion and atopic dermatitis development in Russians and Tatars of Volga-Ural region of Russia.
The levels of filaggrin, inflammatory T helper 2 polarizing cytokines (thymic stromal lymphopoietin (TSLP (show TSLP Antibodies)) and interleukin 33 (IL-33 (show IL33 Antibodies))) and chemokine (C-C motif) ligand 27 (CCL27 (show CCL27 Antibodies)), histological severity markers, T and dendritic cell counts in biopsies from lesional skin of severe atopic dermatitis patients with and without filaggrin mutation and healthy skin were quantified. No significant differences were found.
The imbalance between Th1 (show TH1L Antibodies) and Th2 polarized immune response seems to extend to Filaggrin homeostasis, through the network of Filaggrin processing enzymes.
Levels of FLG (show FGFR1 Antibodies), FLG2 and SPRR3 (show SPRR3 Antibodies) mRNAs and proteins were reduced in AD skin.
Data suggest that the c.1360A>G (p.T454A) and c.10363G>T (p.D3455Y) mutations of the filaggrin (FLG) gene may lead to alteration of the structure and function of the FLG (show FGFR1 Antibodies) protein and cause ichthyosis (show LBR Antibodies) vulgaris in the two families.
Results show a strong association of FLG (show FGFR1 Antibodies) loss-of-function mutations was found with doctor-diagnosed CD and to a lesser extent also with self-reported CD, but not with respiratory symptoms or atopy.
Identify acefylline as an activator of peptidylarginine deiminase 1 and 3 in the epidermis, resulting in filaggrin deimination.
The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.
, basic fibroblast growth factor receptor 1
, proto-oncogene c-Fgr
, epidermal filaggrin
, Filaggrin (profilaggrin)
, keratin intermediate filament-associated protein