You are viewing an incomplete version of our website. Please click to reload the website as full version.

anti-IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1) Antibodies

IKZF1 encodes a transcription factor that belongs to the family of zinc-finger DNA binding proteins associated with chromatin remodeling. Additionally we are shipping IKZF1 Kits (5) and IKZF1 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
IKZF1 22778  
IKZF1 305501  
IKZF1 10320 Q13422
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-IKZF1 Antibodies at antibodies-online.com

Showing 10 out of 138 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-IKZF1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Hela cell lysate Host: Rabbit  Target Name: IKZF1  Sample Tissue: Human Fetal Muscle  Antibody Dilution: 1.0 µg/mL 100 μL Log in to see 2 to 3 Days
$289.00
Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-IKZF1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: ACHN cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-ZNFN1A1 Antibody Titration: 0.2-1 ug/mlPositive Control: Daudi cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB IKZF1 Antibody (C-term) (ABIN654180) flow cytometric analysis of CEM cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated ELISA, WB ABIN334424 (0.03µg/ml) staining of MOLT4 lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Rabbit Un-conjugated EIA, FACS, IHC (p), WB Flow cytometric analysis of CEM cells (right histogram) compared to a negative control cell (left histogram) using IKZF1/IKAROS Antibody (C-term), followed by FITC-conjugated goat-anti-rabbit secondary antibodies. Immunohistochemistry analysis in formalin fixed and paraffin embedded human tonsil tissue using IKZF1/IKAROS Antibody (C-term), followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the IKZF1 antibody for IHC. Clinical relevance has not been evaluated. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Goat Un-conjugated EIA, WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Mouse Mouse Un-conjugated ChIPSeq, ChIP, WB Ikaros antibody (mAb) (Clone 2A9) tested by ChIP-Seq. ChIP was performed using the ChIP-IT® High Sensitivity Kit (Cat. No. 53040) with 30 ug of chromatin from mouse spleen and 4 µg of antibody. ChIP DNA was sequenced on the Illumina HiSeq and 15 million sequence tags were mapped to identify Ikaros binding sites. The image shows binding across a region of chromosome 9. You can view the complete data set in the UCSC Genome Browser, starting at this specific location, here. Ikaros antibody (mAb) (Clone 2A9) tested by Western blot. Detection of Ikaros by Western blot analysis. Ikaros detected in 20 µg mouse spleen whole-cell extract using Ikaros mAb (Clone 2A9) at a 2 µg/ml dilution. 200 μg Log in to see 1 to 2 Days
$478.33
Details
Human Mouse Un-conjugated IP, WB IKAROS (C-terminus) antibody at 1/2000 dilution+K562 whole cell lysate 40ug/Lane, Predicted band size: 58kDa, Observed band size: 58kDa 100 μL Log in to see 8 to 9 Days
$392.86
Details
Mouse Rabbit Un-conjugated WB Ikaros pAb tested by Western blot. Detection of Ikaros by Western blot analysis. Ikaros was detected using a 1:1,000 dilution of Ikaros pAb with 20 µg mouse spleen tissue extract. 200 μL Log in to see 1 to 2 Days
$466.67
Details

IKZF1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) , ,
, ,
,
, , , , , , , , , , , ,
Rat (Rattus) ,
,

, , , , , , , , , , ,
Human , , , ,
, ,
,
, , , , , , , , , , , , , ,

Top referenced anti-IKZF1 Antibodies

  1. Human Polyclonal IKZF1 Primary Antibody for EIA, FACS - ABIN952880 : Yang, Luo, Wei: Integrative genomic analyses on Ikaros and its expression related to solid cancer prognosis. in Oncology reports 2010 (PubMed)
    Show all 5 references for ABIN952880

  2. Human Polyclonal IKZF1 Primary Antibody for EIA, WB - ABIN375210 : Mullighan, Goorha, Radtke, Miller, Coustan-Smith, Dalton, Girtman, Mathew, Ma, Pounds, Su, Pui, Relling, Evans, Shurtleff, Downing: Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. in Nature 2007 (PubMed)

  3. Mouse (Murine) Polyclonal IKZF1 Primary Antibody for WB - ABIN2668752 : Zarnegar, Rothenberg: Ikaros represses and activates PU.1 cell-type-specifically through the multifunctional Sfpi1 URE and a myeloid specific enhancer. in Oncogene 2012 (PubMed)

  4. Mouse (Murine) Monoclonal IKZF1 Primary Antibody for ChIPSeq, ChIP - ABIN2668828 : Yeung, Chung, Guess, Bell, Leinwand: Myh7b/miR-499 gene expression is transcriptionally regulated by MRFs and Eos. in Nucleic acids research 2012 (PubMed)

  5. Chicken Polyclonal IKZF1 Primary Antibody for WB - ABIN2777570 : Loeper, Asa, Ezzat: Ikaros modulates cholesterol uptake: a link between tumor suppression and differentiation. in Cancer research 2008 (PubMed)

  6. Cow (Bovine) Polyclonal IKZF1 Primary Antibody for IHC, WB - ABIN2777569 : Maccarrone, Bari, Di Rienzo, Finazzi-Agrò, Rossi: Progesterone activates fatty acid amide hydrolase (FAAH) promoter in human T lymphocytes through the transcription factor Ikaros. Evidence for a synergistic effect of leptin. in The Journal of biological chemistry 2003 (PubMed)

  7. Human Polyclonal IKZF1 Primary Antibody for FACS, IHC (p) - ABIN654180 : Kuiper, Waanders, van der Velden, van Reijmersdal, Venkatachalam, Scheijen, Sonneveld, van Dongen, Veerman, van Leeuwen, van Kessel, Hoogerbrugge: IKZF1 deletions predict relapse in uniformly treated pediatric precursor B-ALL. in Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2010 (PubMed)

More Antibodies against IKZF1 Interaction Partners

Mouse (Murine) IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1) interaction partners

  1. These results suggest that Ikaros functions as a negative regulator of follicular B cell activation (show BLNK Antibodies).

  2. Ikaros functions as a guardian of B-1 lymphoid pattern, and that its absence directs the differentiation of B-1 cells into phagocytes.

  3. Ikaros is a fundamental regulator of PRC2 function in developing T cells.

  4. Ikaros/Ets1 binding has a role on Ikzf1 expression that is exerted at least through its promoter

  5. deletions on chromosomes 4 and 11 affecting Cdkn2a (show CDKN2A Antibodies) and Ikaros are a prominent feature of young adult irradiation-induced T-cell lymphoma.. tumors arising after irradiation suffer a second hit in Pten (show PTEN Antibodies) by mis (show AMH Antibodies)-segregation or recombination

  6. Murine pancreatic adenocarcinoma reduces Ikaros expression and disrupts T cell homeostasis

  7. The Ikaros family of DNA-binding proteins are critical regulators of lymphocyte differentiation. (Review)

  8. mice with targeted deletion of the fourth DNA-binding zinc finger of the transcription factor Ikaros had increased IL-22 (show IL22 Antibodies)-producing, but not IL-17 (show IL17A Antibodies)-producing, CD4 (show CD4 Antibodies)(+) T cells in the gut (show GUSB Antibodies).

  9. by repressing autocrine IL-2 (show IL2 Antibodies) production, Ikaros ensures that naive CD8 (show CD8A Antibodies)(+) T cells remain dependent on licensing by APCs (show APCS Antibodies) and CD4 (show CD4 Antibodies)(+) T cells, and it may therefore act as a cell-intrinsic safeguard against inappropriate CTL differentiation

  10. binding of Ikaros and expression of its target genes were dynamically regulated at distinct stages of early B lymphopoiesis

Human IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1) interaction partners

  1. Data indicate an oncogenic role for an Ikaros protein/MYCBP2 (show MYCBP2 Antibodies) protein/proto-oncogene (show RAB1A Antibodies) protein c (show PROC Antibodies)-MYC (show MYC Antibodies) axis in adult acute lymphoblastic leukemia (ALL), providing a mechanism of target therapies that activate Ikaros in ALL.

  2. The anti-PEL effects of IMiDs involved cereblon (show CRBN Antibodies)-dependent suppression of IRF4 (show IRF4 Antibodies) and rapid degradation of IKZF1, but not IKZF3 (show IKZF3 Antibodies). Small hairpin RNA-mediated knockdown of MYC (show MYC Antibodies) enhanced the cytotoxicity of IMiDs

  3. A novel, non-canonical splice variant of the Ikaros gene (Ik11) is aberrantly expressed in B-cell lymphoproliferative disorders.

  4. the presented data suggest a mechanism through which Ikaros and HDAC1 (show HDAC1 Antibodies) regulate the epigenetic signature in leukemia: via regulation of JARID1B (show KDM5B Antibodies) transcription.

  5. IKZF1 deletions were detected in 28.7% B-ALL patients, were more common in BCR-ABL (show ABL1 Antibodies) positive and adult B-ALL, and correlated with higher induction failure

  6. all variants of rare IKZF1 deletions are associated with an unfavorable prognosis in pediatric BCP (show OPN1SW Antibodies)-ALL.

  7. We conducted a genome-wide association study for Cold Medicine related -Stevens-Johnson Syndrome /Toxic epidermal necrolysis with SOCs and found that IKZF1 single-nucleotide polymorphisms (SNPs) were significantly associated.

  8. Non-coding variant rs4132601 in IKZF1 was strongly associated with childhood B-cell acute lymphoblastic leukemia. No coding variants were associated with B-ALL susceptibility.

  9. Results suggested that IKAROS family zinc finger 1 (IKZF1) rs4132601 was associated with an increased acute lymphoblastic leukemia (ALL) risk.

  10. variants within IKZF1, ARID5B (show ARID5B Antibodies), and CEBPE (show CEBPE Antibodies) were associated with increased acute lymphoblastic leukemia risk in the California Hispanic population

IKZF1 Antigen Profile

Protein Summary

This gene encodes a transcription factor that belongs to the family of zinc-finger DNA binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. All isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homodimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and contain the nuclear localization signal, resulting in members with and without DNA-binding properties. Only few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and thought to function as dominant negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL).

Gene names and symbols associated with IKZF1

  • IKAROS family zinc finger 1 (Ikzf1) antibody
  • IKAROS family zinc finger 1 (Ikaros) (IKZF1) antibody
  • IKAROS family zinc finger 1 (Ikaros) (ikzf1) antibody
  • Ikaros homolog (ikaros) antibody
  • 5832432G11Rik antibody
  • hIk-1 antibody
  • hlk-1 antibody
  • Hs.54452 antibody
  • IK1 antibody
  • ikaros antibody
  • ikzf1 antibody
  • LyF-1 antibody
  • LYF1 antibody
  • mKIAA4227 antibody
  • PRO0758 antibody
  • RGD1562979 antibody
  • Zfpn1a1 antibody
  • znfn1a1 antibody

Protein level used designations for IKZF1

DNA-binding protein Ikaros , ikaros family zinc finger protein 1 , lymphoid transcription factor LyF-1 , zinc finger protein subfamily 1A, 1 , zinc finger protein, subfamily 1A, 1 (Ikaros) , CLL-associated antigen KW-6 , Ikaros (zinc finger protein) , Ikaros transcription factor , KAROS family zinc finger 1 (Ikaros)

GENE ID SPECIES
22778 Mus musculus
305501 Rattus norvegicus
10320 Homo sapiens
395974 Gallus gallus
483231 Canis lupus familiaris
541154 Bos taurus
30177 Danio rerio
100136762 Oncorhynchus mykiss
Selected quality suppliers for anti-IKZF1 (IKZF1) Antibodies
Did you look for something else?