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IKZF1 encodes a transcription factor that belongs to the family of zinc-finger DNA binding proteins associated with chromatin remodeling. Additionally we are shipping IKZF1 Kits (5) and IKZF1 Proteins (4) and many more products for this protein.
Showing 10 out of 138 products:
Human Polyclonal IKZF1 Primary Antibody for EIA, FACS - ABIN952880
Yang, Luo, Wei: Integrative genomic analyses on Ikaros and its expression related to solid cancer prognosis. in Oncology reports 2010
Show all 5 references for ABIN952880
Human Polyclonal IKZF1 Primary Antibody for EIA, WB - ABIN375210
Mullighan, Goorha, Radtke, Miller, Coustan-Smith, Dalton, Girtman, Mathew, Ma, Pounds, Su, Pui, Relling, Evans, Shurtleff, Downing: Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. in Nature 2007
Mouse (Murine) Polyclonal IKZF1 Primary Antibody for WB - ABIN2668752
Zarnegar, Rothenberg: Ikaros represses and activates PU.1 cell-type-specifically through the multifunctional Sfpi1 URE and a myeloid specific enhancer. in Oncogene 2012
Mouse (Murine) Monoclonal IKZF1 Primary Antibody for ChIPSeq, ChIP - ABIN2668828
Yeung, Chung, Guess, Bell, Leinwand: Myh7b/miR-499 gene expression is transcriptionally regulated by MRFs and Eos. in Nucleic acids research 2012
Chicken Polyclonal IKZF1 Primary Antibody for WB - ABIN2777570
Loeper, Asa, Ezzat: Ikaros modulates cholesterol uptake: a link between tumor suppression and differentiation. in Cancer research 2008
Cow (Bovine) Polyclonal IKZF1 Primary Antibody for IHC, WB - ABIN2777569
Maccarrone, Bari, Di Rienzo, Finazzi-Agrò, Rossi: Progesterone activates fatty acid amide hydrolase (FAAH) promoter in human T lymphocytes through the transcription factor Ikaros. Evidence for a synergistic effect of leptin. in The Journal of biological chemistry 2003
Human Polyclonal IKZF1 Primary Antibody for FACS, IHC (p) - ABIN654180
Kuiper, Waanders, van der Velden, van Reijmersdal, Venkatachalam, Scheijen, Sonneveld, van Dongen, Veerman, van Leeuwen, van Kessel, Hoogerbrugge: IKZF1 deletions predict relapse in uniformly treated pediatric precursor B-ALL. in Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2010
These results suggest that Ikaros functions as a negative regulator of follicular B cell activation (show BLNK Antibodies).
Ikaros functions as a guardian of B-1 lymphoid pattern, and that its absence directs the differentiation of B-1 cells into phagocytes.
Ikaros is a fundamental regulator of PRC2 function in developing T cells.
Ikaros/Ets1 binding has a role on Ikzf1 expression that is exerted at least through its promoter
deletions on chromosomes 4 and 11 affecting Cdkn2a (show CDKN2A Antibodies) and Ikaros are a prominent feature of young adult irradiation-induced T-cell lymphoma.. tumors arising after irradiation suffer a second hit in Pten (show PTEN Antibodies) by mis (show AMH Antibodies)-segregation or recombination
Murine pancreatic adenocarcinoma reduces Ikaros expression and disrupts T cell homeostasis
The Ikaros family of DNA-binding proteins are critical regulators of lymphocyte differentiation. (Review)
mice with targeted deletion of the fourth DNA-binding zinc finger of the transcription factor Ikaros had increased IL-22 (show IL22 Antibodies)-producing, but not IL-17 (show IL17A Antibodies)-producing, CD4 (show CD4 Antibodies)(+) T cells in the gut (show GUSB Antibodies).
by repressing autocrine IL-2 (show IL2 Antibodies) production, Ikaros ensures that naive CD8 (show CD8A Antibodies)(+) T cells remain dependent on licensing by APCs (show APCS Antibodies) and CD4 (show CD4 Antibodies)(+) T cells, and it may therefore act as a cell-intrinsic safeguard against inappropriate CTL differentiation
binding of Ikaros and expression of its target genes were dynamically regulated at distinct stages of early B lymphopoiesis
Data indicate an oncogenic role for an Ikaros protein/MYCBP2 (show MYCBP2 Antibodies) protein/proto-oncogene (show RAB1A Antibodies) protein c (show PROC Antibodies)-MYC (show MYC Antibodies) axis in adult acute lymphoblastic leukemia (ALL), providing a mechanism of target therapies that activate Ikaros in ALL.
The anti-PEL effects of IMiDs involved cereblon (show CRBN Antibodies)-dependent suppression of IRF4 (show IRF4 Antibodies) and rapid degradation of IKZF1, but not IKZF3 (show IKZF3 Antibodies). Small hairpin RNA-mediated knockdown of MYC (show MYC Antibodies) enhanced the cytotoxicity of IMiDs
A novel, non-canonical splice variant of the Ikaros gene (Ik11) is aberrantly expressed in B-cell lymphoproliferative disorders.
the presented data suggest a mechanism through which Ikaros and HDAC1 (show HDAC1 Antibodies) regulate the epigenetic signature in leukemia: via regulation of JARID1B (show KDM5B Antibodies) transcription.
IKZF1 deletions were detected in 28.7% B-ALL patients, were more common in BCR-ABL (show ABL1 Antibodies) positive and adult B-ALL, and correlated with higher induction failure
all variants of rare IKZF1 deletions are associated with an unfavorable prognosis in pediatric BCP (show OPN1SW Antibodies)-ALL.
We conducted a genome-wide association study for Cold Medicine related -Stevens-Johnson Syndrome /Toxic epidermal necrolysis with SOCs and found that IKZF1 single-nucleotide polymorphisms (SNPs) were significantly associated.
Non-coding variant rs4132601 in IKZF1 was strongly associated with childhood B-cell acute lymphoblastic leukemia. No coding variants were associated with B-ALL susceptibility.
Results suggested that IKAROS family zinc finger 1 (IKZF1) rs4132601 was associated with an increased acute lymphoblastic leukemia (ALL) risk.
variants within IKZF1, ARID5B (show ARID5B Antibodies), and CEBPE (show CEBPE Antibodies) were associated with increased acute lymphoblastic leukemia risk in the California Hispanic population
This gene encodes a transcription factor that belongs to the family of zinc-finger DNA binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. All isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homodimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and contain the nuclear localization signal, resulting in members with and without DNA-binding properties. Only few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and thought to function as dominant negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL).
DNA-binding protein Ikaros
, ikaros family zinc finger protein 1
, lymphoid transcription factor LyF-1
, zinc finger protein subfamily 1A, 1
, zinc finger protein, subfamily 1A, 1 (Ikaros)
, CLL-associated antigen KW-6
, Ikaros (zinc finger protein)
, Ikaros transcription factor
, KAROS family zinc finger 1 (Ikaros)