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IKZF1 Products

(IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1))

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This gene encodes a transcription factor that belongs to the family of zinc-finger DNA binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. All isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homodimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and contain the nuclear localization signal, resulting in members with and without DNA-binding properties. Only few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and thought to function as dominant negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2011].

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Featured IKZF1 Categories

IKZF1 Antibodies

High quality antibodies with extensive validation data.

IKZF1 ELISA Kits

Reliable ELISA kits for a wide range of species.

IKZF1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended IKZF1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, FACS, IHC (p)
Validations
  • (1)
  • (4)
Cat. No. ABIN654180
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (4)
Cat. No. ABIN7150361
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IF, ChIP
Validations
  • (4)
Cat. No. ABIN3015622
Quantity 100 μL
Datasheet Datasheet

Recommended IKZF1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6967566
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1130242
Quantity 96 tests
Datasheet Datasheet
Reactivity Chicken
Analytical Method
Validations
Cat. No. ABIN1130240
Quantity 96 tests
Datasheet Datasheet

Recommended IKZF1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7123400
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1307650
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3093023
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our IKZF1 products

Gao, Geng, Song, Lin, Liu, Cai, Cang: "Activation of c-Abl Kinase Potentiates the Anti-myeloma Drug Lenalidomide by Promoting DDA1 Protein Recruitment to the CRL4 Ubiquitin Ligase." in: The Journal of biological chemistry, Vol. 292, Issue 9, pp. 3683-3691, (2017) (PubMed).

Wang, Song, Ding, Pan, Ge, Tan, Gowda, Sachdev, Muthusami, Ouyang, Lai, Francis, Morris, Abdel-Azim, Dorsam, Xiang, Payne, Dovat: "Transcriptional Regulation of JARID1B/KDM5B Histone Demethylase by Ikaros, Histone Deacetylase 1 (HDAC1), and Casein Kinase 2 (CK2) in B-cell Acute Lymphoblastic Leukemia." in: The Journal of biological chemistry, Vol. 291, Issue 8, pp. 4004-18, (2016) (PubMed).

Iempridee, Reusch, Riching, Johannsen, Dovat, Kenney, Mertz: "Epstein-Barr virus utilizes Ikaros in regulating its latent-lytic switch in B cells." in: Journal of virology, Vol. 88, Issue 9, pp. 4811-27, (2014) (PubMed).

Yoshida, Landhuis, Dose, Hazan, Zhang, Naito, Jackson, Wu, Perotti, Kaufmann, Gounari, Morgan, Georgopoulos: "Transcriptional regulation of the Ikzf1 locus." in: Blood, Vol. 122, Issue 18, pp. 3149-59, (2013) (PubMed).

Zarnegar, Rothenberg: "Ikaros represses and activates PU.1 cell-type-specifically through the multifunctional Sfpi1 URE and a myeloid specific enhancer." in: Oncogene, Vol. 31, Issue 43, pp. 4647-54, (2012) (PubMed).

Yeung, Chung, Guess, Bell, Leinwand: "Myh7b/miR-499 gene expression is transcriptionally regulated by MRFs and Eos." in: Nucleic acids research, Vol. 40, Issue 15, pp. 7303-18, (2012) (PubMed).

Loeper, Asa, Ezzat: "Ikaros modulates cholesterol uptake: a link between tumor suppression and differentiation." in: Cancer research, Vol. 68, Issue 10, pp. 3715-23, (2008) (PubMed).

Mullighan, Goorha, Radtke, Miller, Coustan-Smith, Dalton, Girtman, Mathew, Ma, Pounds, Su, Pui, Relling, Evans, Shurtleff, Downing: "Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia." in: Nature, Vol. 446, Issue 7137, pp. 758-64, (2007) (PubMed).

Georgopoulos: "Haematopoietic cell-fate decisions, chromatin regulation and ikaros." in: Nature reviews. Immunology, Vol. 2, Issue 3, pp. 162-74, (2002) (PubMed).

Westman, Mackay, Gell: "Ikaros: a key regulator of haematopoiesis." in: The international journal of biochemistry & cell biology, Vol. 34, Issue 10, pp. 1304-7, (2002) (PubMed).

Synonyms and alternative names related to IKZF1

IKAROS family zinc finger 1 (IKZF1), IKAROS family zinc finger 1 (Ikzf1), IKAROS family zinc finger 1 (Ikaros) (ikzf1), IKAROS family zinc finger 1 (ikzf1), 5832432G11Rik, hIk-1, hik-1, hlk-1, Hs.54452, hs.54452, IK1, ik1, IKAROS, ikaros, Ikaros, ikzf1, LyF-1, LYF1, lyf1, MGC108252, mKIAA4227, PRO0758, pro0758, RGD1562979, Zfpn1a1, ZNFN1A1, znfn1a1, Znfn1a1

Protein level used designations for IKZF1

  • CLL-associated antigen KW-6
  • DNA-binding protein Ikaros
  • Ikaros (zinc finger protein)
  • ikaros family zinc finger protein 1
  • lymphoid transcription factor LyF-1
  • zinc finger protein, subfamily 1A, 1 (Ikaros)
  • Ikaros transcription factor
  • KAROS family zinc finger 1 (Ikaros)
  • IKAROS family zinc finger 1 (Ikaros)
  • DNA-binding protein Ikaros-like
  • zinc finger protein subfamily 1A, 1
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