IKAROS Family Zinc Finger 3 (Aiolos) Proteins (IKZF3)

IKZF3 encodes a member of the Ikaros family of zinc-finger proteins. Additionally we are shipping IKZF3 Antibodies (147) and IKZF3 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
IKZF3 22806 Q9UKT9
IKZF3 22780 O08900
Rat IKZF3 IKZF3 303511  
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Top IKZF3 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
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IKZF3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for IKAROS Family Zinc Finger 3 (Aiolos) (IKZF3) Interaction Partners

Human IKAROS Family Zinc Finger 3 (Aiolos) (IKZF3) interaction partners

  1. Inhibition of B cell plasmablast differentiation by reduction of Aiolos and Ikaros (show IKZF1 Proteins) may have utility in the treatment of systemic lupus erythematosus , where elevated levels of BAFF (show TNFSF13B Proteins) and Aiolos may prime CD27 (show CD27 Proteins)(+) memory and double negative memory-like B cells to become Ab-producing plasmablasts in the presence of BAFF (show TNFSF13B Proteins) and proinflammatory cytokines.

  2. this study shows that Ikaros (show IKZF1 Proteins) undergoes a transient increase in protein levels at the transitional single-positive CD8 (show CD8A Proteins)+ developmental stage before diverging in their expression patterns at later stages

  3. Our data indicate a possible regulatory role for the multiple sclerosis-associated IKZF3 and IQGAP1 variants.

  4. results indicate that overexpression of Aiolos may contribute to pathogenesis of SLE and RA

  5. Aiolos improved the survival of Nalm6 cells via PTEN and Aktdependent processes.

  6. NFKB1 (show NFKB1 Proteins), CD27 (show CD27 Proteins), LAG3 (show LAG3 Proteins) and IKZF3 are new susceptibility genes for psoriasis.

  7. lentivirus-mediated AIOLOS overexpression in Jurkat cells induced cell apoptosis, arrested the cell cycle at the G0/G1 phase, and synergistically increased the sensitivity of Jurkat cells to etoposide by inhibiting NF-kappaB (show NFKB1 Proteins) activity.

  8. The allele T of rs10852936 surrounding the IKZF3-ZPBP2 (show ZPBP2 Proteins) locus confers risk for early-onset psoriasis.

  9. A strong association between rs907091 in the IKZF3 gene and SLE was identified.

  10. The immunosuppressive enzyme IL4I1 (show IL4I1 Proteins) expressed differentially in human induced Aiolos+, but not natural Helios (show ZNFN1A2 Proteins)+, FOXP3 (show FOXP3 Proteins)+ Treg cells.

Mouse (Murine) IKAROS Family Zinc Finger 3 (Aiolos) (IKZF3) interaction partners

  1. These data place Aiolos in the emerging gene regulatory network controlling NK-cell maturation and function.

  2. study demonstrated that Aiolos silenced the Il2 (show IL2 Proteins) locus, promoting TH17 differentiation in vitro and in vivo

  3. Aiolos and Ikaros (show IKZF1 Proteins) bind to the c-myc (show MYC Proteins) promoter in vivo and directly suppress c-myc (show MYC Proteins) expression in pre-B cells.

  4. Normal Aiolos function is necessary to maintain immune homeostasis and suppress the development of systemic autoimmune disease; Aiolos is implicated as a possible candidate gene for systemic lupus erythematosus.

  5. A model is proposed for the control of Bcl-xL's anti-apoptotic role in IL-4 (show IL4 Proteins)-deprived cells via association to the transcription factor Aiolos.

  6. Failure to generate high affinity plasma cells in the bone marrow and to sustain serum antibody titers is apparent after both primary and secondary immunization of Aiolos(-)(/)(-) mice with a range of hapten concentrations.

  7. A novel role for OBF-1 (show POU2AF1 Proteins) and Aiolos in controlling the transcription and nuclear organization of genes involved in pre-BCR (show BCR Proteins) function.

IKZF3 Protein Profile

Protein Summary

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants.

Gene names and symbols associated with IKZF3

  • IKAROS family zinc finger 3 (IKZF3)
  • IKAROS family zinc finger 3 L homeolog (ikzf3.L)
  • IKAROS family zinc finger 3 (Ikzf3)
  • 5830411O07Rik protein
  • aio protein
  • Aiolos protein
  • IKZF3 protein
  • Zfpn1a3 protein
  • Znfn1a3 protein

Protein level used designations for IKZF3

zinc finger protein Aiolos , zinc finger protein, subfamily 1A, 3 (Aiolos) , lymphoid transcription factor , IKAROS family zinc finger 3 (Aiolos) , ikaros family zinc finger protein 3 , zinc finger protein Aiolos-like

GENE ID SPECIES
22806 Homo sapiens
444381 Xenopus laevis
395614 Gallus gallus
468232 Pan troglodytes
491020 Canis lupus familiaris
540676 Bos taurus
698083 Macaca mulatta
100015975 Monodelphis domestica
100085644 Ornithorhynchus anatinus
100392424 Callithrix jacchus
100445787 Pongo abelii
100604740 Nomascus leucogenys
22780 Mus musculus
303511 Rattus norvegicus
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