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anti-Indoleamine 2,3-Dioxygenase 2 (IDO2) Antibodies

Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMed 17499941]).[supplied by OMIM, Feb 2011].. Additionally we are shipping IDO2 Proteins (8) and IDO2 Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
IDO2 169355 Q6ZQW0
IDO2 681319  
IDO2 209176  
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Top anti-IDO2 Antibodies at

Showing 10 out of 120 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Goat Un-conjugated EIA, WB 0.1 mg Log in to see 6 to 8 Days
Mouse Mouse Un-conjugated ELISA, WB Western Blot of Mouse Anti-IDO2 antibody. Lane 1: HEK293 no transgene cell extracts. Lane 2: mouse IDO-2 transgene expressed in 293HEK. Lane 3: mouse IDO-1 transgene expressed in 293HEK. Primary antibody: IDO2 monoclonal Antibody. Secondary antibody: IRDye800™ mouse secondary antibody at 1:10,000 for 45 min at RT. Block: 5% BLOTTO overnight at 4°C. Predicted/Observed size: 44.4 kDa, ~60 kDa for IDO 2. Other band(s): IDO2 splice variants and isoforms 25 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue reacted with IDO2 / INDOL1 Antibody (C-term) followed by peroxidase conjugation of the secondary antibody and DAB staining. Western blot analysis of IDO2 / INDOL1 Antibody (C-term) in K562 cell line lysates (35ug/lane). 0.4 mL Log in to see 6 to 8 Days
Mouse Rabbit Un-conjugated IHC, ELISA, WB Immunofluorescence of Anti-IDO2 Antibody. Tissue: human IDO2 expressing HEK293 cells. Fixation: 0.5% PFA. Antigen retrieval: not required. Primary: IDO2 antibody at 1:50-1:1000 for 1 h at RT. Secondary: Peroxidase rabbit secondary antibody at 1:10,000 for 45min at RT. Localization: IDO-2 is located in the cytosol. Staining: IDO-2 as green fluorescent signal with bis-benzimide nuclear counterstain (blue). 100 μg Log in to see 2 to 3 Days
Human Rabbit Un-conjugated WB WB Suggested Anti-IDO2 AntibodyTitration: 1.0 µg/mL  Positive Control: Fetal Brain 100 μL Log in to see 2 to 3 Days
Human Mouse Un-conjugated FACS, WB HEK293T cells transfected with either RC223337 overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-IDO2 antibody (ABIN2453838), and then analyzed by flow cytometry. HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY IDO2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-IDO2. 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
Human Rabbit Un-conjugated WB Anti-INDOL1 antibody, Western blotting Lane 1: A549 Cell Lysate Lane 2: Human Placenta Tissue Lysate Lane 3: A431 Cell Lysate 100 μg Log in to see 4 to 6 Days
Human Rabbit Un-conjugated WB Western blot analysis of IDO2 expression in HepG2 (A), Raw264.7 (B), PC12 (C) whole cell lysates. 200 μL Log in to see 9 Days

IDO2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-IDO2 Antibodies

  1. Human Polyclonal IDO2 Primary Antibody for EIA, IHC (p) - ABIN952817 : Cetindere, Nambiar, Santourlidis, Essmann, Hassan: Induction of indoleamine 2, 3-dioxygenase by death receptor activation contributes to apoptosis of melanoma cells via mitochondrial damage-dependent ROS accumulation. in Cellular signalling 2009 (PubMed)
    Show all 5 references for ABIN952817

  2. Cow (Bovine) Polyclonal IDO2 Primary Antibody for EIA, WB - ABIN401520 : Metz, Duhadaway, Kamasani, Laury-Kleintop, Muller, Prendergast: Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan. in Cancer research 2007 (PubMed)

  3. Mouse (Murine) Polyclonal IDO2 Primary Antibody for IHC, ELISA - ABIN1043908 : Wolff, Driever, Erdlenbruch, Kortmann, Rutkowski, Pietsch, Parker, Metz, Gnekow, Kramm: Intensive chemotherapy improves survival in pediatric high-grade glioma after gross total resection: results of the HIT-GBM-C protocol. in Cancer 2010 (PubMed)

More Antibodies against IDO2 Interaction Partners

Human Indoleamine 2,3-Dioxygenase 2 (IDO2) interaction partners

  1. functional importance of IDO (show IDO1 Antibodies) enzymes in human Crohn's disease

  2. Human indoleamine 2,3-dioxygenase-2 has substrate specificity and inhibition characteristics distinct from those of indoleamine 2,3-dioxygenase-1 (show IDO1 Antibodies)

  3. These results demonstrate that IDO2 plays a novel role as a negative regulator of IDO1 (show IDO1 Antibodies) by competing for heme-binding with IDO1 (show IDO1 Antibodies).

  4. The IDO2 is now known to catalyze the first and rate-limiting step in the catabolism of tryptophan along a relative newcomer to the kynurenine pathway field.

  5. Multiple-scattering (MS) analysis of EXAFS data on met-indoleamine 2,3-dioxygenase-2 (IDO2) and analysis of XANES have provided the first direct structural information about the axial donor ligands of the iron center for this recently discovered protein.

  6. IDO2 is expressed in both mDCs and plasmacytoid DCs and is not modulated by PGE2. IDO2 expression is constitutively, stably expressed in steady-state conditions and may contribute to the homeostatic tolerogenic capacity of DCs.

  7. Indoleamine2,3-dioxygenase and tryptophanyl-tRNA synthetase (show WARS Antibodies) may play critical roles in the immune pathogenesis of chronic kidney disease.

  8. Purification and kinetic characterization of human indoleamine 2,3-dioxygenases 1 and 2 (IDO1 (show IDO1 Antibodies) and IDO2) and discovery of selective IDO1 (show IDO1 Antibodies) inhibitors.

  9. Data show that IDO2-specific T cells are cytotoxic effector cells that recognize and kill tumor cells.

  10. Tryptophan supplementation was able to completely restore hepatitis b virus replication in IFN-gamma (show IFNG Antibodies)- but not IFN-alpha (show IFNA Antibodies)-treated cells, which strongly argues that IDO (show IDO1 Antibodies) is the primary mediator of IFN-gamma (show IFNG Antibodies)-elicited antiviral response in human hepatocytes.

Mouse (Murine) Indoleamine 2,3-Dioxygenase 2 (IDO2) interaction partners

  1. Ido2 may be important for mouse embryo implantation and decidualization.

  2. The data showed that there is not significant effect of IDO1 (show IDO1 Antibodies) or TDO2 (show TDO2 Antibodies) on mortality in pneumococcal meningitis.

  3. IDO2 is critical for IDO1 (show IDO1 Antibodies)-mediated T-cell regulation and exerts a non-redundant function in inflammation.

  4. Deletion of Ido1 (show IDO1 Antibodies) and reduced mRNA expression for Ido2 neither affected the concentration of the downstream metabolites of tryptophan nor mRNA expression for downstream genes on the kynurenine pathway in inguinal lymph nodes.

  5. results provide important insights into IDO2 function by defining its pathogenic contributions to autoantibody-mediated autoimmunity.

  6. Immunohistochemical analysis in Ido1 (show IDO1 Antibodies)(-/-) mouse epididymis showed that Ido2 protein was extensively upregulated due to the loss of Ido1 (show IDO1 Antibodies) expression.

  7. IDO-1 (show IDO1 Antibodies) and IDO-2 play biologically important, contradictory roles during intracellular protozoal infection - facilitating (Toxoplasma gondii) or suppressing (Leishmania major) microbial clearance in a pathogen-specific manner.

  8. Findings implicate novel IDO (show IDO1 Antibodies) related enzyme IDO2 in cancer as a result of its preferential inhibition by the D racemer of 1-methyl-tryptophan, used widely in its racemic form (D,L-1MT) as an IDO (show IDO1 Antibodies) inhibitor including as an anticancer agent

  9. A second tryptophan catabolic enzyme inducible by IFNg (show IFNG Antibodies), implicated in transcriptional immune regulation (IFNg (show IFNG Antibodies)-driven negative feedback), may limit the pro-inflammatory and anti-proliferative functions(Review)

  10. This article describes the evolutionary relationships between the INDO (show IDO1 Antibodies) and INDOL1 genes. The INDOL1 protein has a distinct expression pattern compared to INDO (show IDO1 Antibodies) and both have the ability to catabolise tryptophan.

IDO2 Antigen Profile

Protein Summary

Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007

Gene names and symbols associated with IDO2

  • indoleamine 2,3-dioxygenase 2 (IDO2) antibody
  • indoleamine 2,3-dioxygenase 2 (Ido2) antibody
  • AI265623 antibody
  • C230043N17Rik antibody
  • Ido-2 antibody
  • Indol1 antibody

Protein level used designations for IDO2

indoleamine 2,3-dioxygenase 2 , indoleamine 2,3-dioxygenase 2-like , IDO-2 , indoleamine 2,3-dioxygenase-like 1 protein , indoleamine 2,3-dioxygenase-like protein 1 , indoleamine-pyrrole 2,3 dioxygenase-like 1 , indoleamine-pyrrole 2,3-dioxygenase-like protein 1

100402049 Callithrix jacchus
707424 Macaca mulatta
100085939 Ornithorhynchus anatinus
100435160 Pongo abelii
100480334 Ailuropoda melanoleuca
100580956 Nomascus leucogenys
169355 Homo sapiens
482846 Canis lupus familiaris
513810 Bos taurus
681319 Rattus norvegicus
209176 Mus musculus
100056686 Equus caballus
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