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anti-Integrin-Binding Sialoprotein (IBSP) Antibodies

The protein encoded by IBSP is a major structural protein of the bone matrix. Additionally we are shipping Integrin-Binding Sialoprotein Kits (12) and Integrin-Binding Sialoprotein Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
IBSP 25373 P24090
IBSP 15891 Q61711
IBSP 3381 P21815
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Top anti-Integrin-Binding Sialoprotein Antibodies at

Showing 10 out of 85 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB IBSP Antibody (N-term) (ABIN658035) western blot analysis in CEM cell line lysates (35 µg/lane). This demonstrates the IBSP antibody detected the IBSP protein (arrow). 400 μL Log in to see 10 to 11 Days
Human Rabbit Un-conjugated WB WB Suggested Anti-IBSP Antibody Titration: 1.25ug/mlELISA Titer: 1:62500Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
Human Mouse Un-conjugated EIA, IHC (fro), IF, IHC (p), RIA, WB 0.1 mg Log in to see 6 to 8 Days
Human Chicken Un-conjugated EIA, FACS, IF, IHC (p), RIA, WB 0.1 mg Log in to see 6 to 8 Days
Mouse Rabbit Un-conjugated IHC (p), WB Anti-Bone Sialoprotein antibody, Western blotting Lane 1: Rat Liver Tissue Lysate Lane 2: Rat Brain Tissue Lysate Lane 3: Rat Kidney Tissue Lysate Anti-Bone Sialoprotein antibody, IHC(P) IHC(P): Rat Liver Tissue 100 μg Log in to see 4 to 6 Days
Human Rabbit Un-conjugated IHC (p), WB Anti-Bone Sialoprotein antibody, IHC(P) IHC(P): Human Osteosarcoma Tissue 100 μg Log in to see 4 to 6 Days
Human Rabbit Un-conjugated FACS, IF (p), IHC (p), WB   100 μL Log in to see 3 to 7 Days
Human Rat Un-conjugated EIA, WB 0.1 mg Log in to see 10 to 12 Days
Human Rabbit Un-conjugated ELISA, WB 100 μg Log in to see 2 to 3 Days
Human Rabbit Un-conjugated EIA, IF, WB 0.1 mL Log in to see 6 to 8 Days

IBSP Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Integrin-Binding Sialoprotein Antibodies

  1. Human Monoclonal IBSP Primary Antibody for EIA, IHC (fro) - ABIN191977 : Ibrahim, Leong, Sanchez-Sweatman, Khokha, Sodek, Tenenbaum, Ganss, Cheifetz: Expression of bone sialoprotein and osteopontin in breast cancer bone metastases. in Clinical & experimental metastasis 2001 (PubMed)
    Show all 8 references for ABIN191977

  2. Human Polyclonal IBSP Primary Antibody for EIA, FACS - ABIN191813 : Karmatschek, Maier, Seibel, Woitge, Ziegler, Armbruster: Improved purification of human bone sialoprotein and development of a homologous radioimmunoassay. in Clinical chemistry 1997 (PubMed)
    Show all 4 references for ABIN191813

  3. Human Polyclonal IBSP Primary Antibody for FACS, IF (p) - ABIN748838 : Yang, Hai, Qin, Ti, Shangguan, Zhao, Wiggins, Liu, Feng, Chang, Wang, Liu: Cessation of epithelial Bmp signaling switches the differentiation of crown epithelia to the root lineage in a ?-catenin-dependent manner. in Molecular and cellular biology 2013 (PubMed)
    Show all 2 references for ABIN748838

  4. Human Polyclonal IBSP Primary Antibody for WB - ABIN658035 : Yerges, Klei, Cauley, Roeder, Kammerer, Moffett, Ensrud, Nestlerode, Marshall, Hoffman, Lewis, Lang, Barrett-Connor, Ferrell, Orwoll, Zmuda: High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009 (PubMed)
    Show all 2 references for ABIN658035

  5. Human Polyclonal IBSP Primary Antibody for WB - ABIN2774907 : Barnes, Javed, Waller, Kamal, Hebert, Hassan, Bellahcene, Van Wijnen, Young, Lian, Stein, Gerstenfeld: Osteoblast-related transcription factors Runx2 (Cbfa1/AML3) and MSX2 mediate the expression of bone sialoprotein in human metastatic breast cancer cells. in Cancer research 2003 (PubMed)

More Antibodies against Integrin-Binding Sialoprotein Interaction Partners

Mouse (Murine) Integrin-Binding Sialoprotein (IBSP) interaction partners

  1. OPN (show SPP1 Antibodies) induces oxidative stress via the involvement of mitochondria and NOX-4 (show NOX4 Antibodies). It may affect mitochondrial morphology and integrity, at least in part, via the involvement of BIK (show BIK Antibodies).

  2. Endogenous osteopontin (show SPP1 Antibodies) plays a critical role in the prevention of phosphate-induced nephrocalcinosis and vascular calcification in response to high phosphate load.

  3. GATA4 (show GATA4 Antibodies) acts as a negative regulator of Bsp (show KLK6 Antibodies) expression in osteoblasts.

  4. Genetic deletion of osteopontin (show SPP1 Antibodies) in TRAMP (show DPT Antibodies) mice skews prostate carcinogenesis from adenocarcinoma to aggressive human-like neuroendocrine cancers.

  5. IFN-gamma (show IFNG Antibodies) regulates hypertensive vascular collagen remodeling induced by ANG II (show AGT Antibodies) and inhibits the differentiation of Th17 cells by suppressing OPN (show SPP1 Antibodies) expression and regulating secretion of inflammatory cytokines.

  6. results indicate that autocrine OPN (show SPP1 Antibodies) plays a crucial role in HPC expansion, migration, and subsequent oncogenic transformation of HPCs, which may provide a new insight into hepatocarcinogenesis

  7. OPN (show SPP1 Antibodies) produced by hematogenous macrophages induces astrocyte process extension toward the infarct border zone, which may contribute to repair of the ischemic neurovascular unit following stroke

  8. During the priming phase of liver regeneration, osteopontin (show SPP1 Antibodies) enhances the recruitment of macrophages and neutrophils, and triggers hepatocyte proliferation through Kupffer cell-derived IL-6 (show IL6 Antibodies) release and the downstream activation of Stat3 (show STAT3 Antibodies).

  9. OPN (show SPP1 Antibodies) deficiency accelerated the spontaneous development of colitis in mice with disrupted gut (show GUSB Antibodies) microbiota and macrophage phagocytic activity.

  10. mechanical stretch (MS) directly increased OPN (show SPP1 Antibodies) protein expression and secretion in vascular smooth muscle cells.

Human Integrin-Binding Sialoprotein (IBSP) interaction partners

  1. In conclusion, serum levels of BSP (show KLK6 Antibodies), ALP (show ALP Antibodies), ICTP, and PSA (show PLAG1 Antibodies) increased in patients with bone metastases, and combined detection of all markers could improve the positive-predictive value.

  2. Preameloblast-Derived Factors Mediate Osteoblast Differentiation of Human Bone Marrow Mesenchymal Stem Cells by Runx2 (show RUNX2 Antibodies)-Osterix (show SP7 Antibodies)-BSP (show KLK6 Antibodies) Signaling.

  3. Two significant SNPs within IBSP, rs1054627 and rs17013181, were associated with BMD (show BEST1 Antibodies) and postmenopausal osteoporosis by the two-stage strategy, and rs17013181 was also significantly associated with serum IBSP levels.

  4. Our results suggest that SSEA (show MPST Antibodies)-4 is a specific cell surface antigen (show CD53 Antibodies) that can be used to identify dental pulp stem cells.

  5. the strong correlation between bone sialoprotein (show CRISP1 Antibodies) and OPN (show SPP1 Antibodies) and papillary thyroid carcinoma suggests a role for BSP (show KLK6 Antibodies) and OPN (show SPP1 Antibodies) in calcification and tumor progression of papillary thyroid carcinoma

  6. oxidized low-density lipoprotein-induced expression dependent on Runx2 (show RUNX2 Antibodies) expression

  7. Bone sialoprotein (show CRISP1 Antibodies) could be a key mediator of the hypertrophic chondrocytes-induced angiogenesis of osteoarthritis.

  8. Current evidence demonstrates that BSP (show KLK6 Antibodies) and OPN (show SPP1 Antibodies), play significant roles in bone metastasis of osteotropic malignancies derived from breast, prostate, lung, thyroid, and multiple myeloma. [review]

  9. High expression of bone sialoprotein (show CRISP1 Antibodies) in breast neoplasms was associated with cytokeratin (show KRT4 Antibodies)-positive cells in bone marrow, but not with lymph node metastasis.

  10. results indicate that FGF2 (show FGF2 Antibodies) increases BSP (show KLK6 Antibodies) transcription by targeting the FRE (show FRZB Antibodies) and AP1 (show FOSB Antibodies) elements in the proximal promoter of the human BSP (show KLK6 Antibodies) gene.

Integrin-Binding Sialoprotein (IBSP) Antigen Profile

Protein Summary

The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor.

Gene names and symbols associated with IBSP

  • integrin-binding sialoprotein (IBSP) antibody
  • integrin-binding sialoprotein (ibsp) antibody
  • integrin-binding sialoprotein (LOC100344425) antibody
  • alpha-2-HS-glycoprotein (Ahsg) antibody
  • integrin binding sialoprotein (Ibsp) antibody
  • integrin-binding sialoprotein (Ibsp) antibody
  • secreted phosphoprotein 1 (Spp1) antibody
  • 2AR antibody
  • Aa2-066 antibody
  • Apl-1 antibody
  • BNSP antibody
  • Bsp antibody
  • BSP-II antibody
  • Bsp2 antibody
  • BSPI antibody
  • BSP II antibody
  • BSPII antibody
  • Eta antibody
  • ETA-1 antibody
  • IBSP antibody
  • OP antibody
  • Opn antibody
  • Opnl antibody
  • pp63 antibody
  • Ric antibody
  • SP-II antibody
  • Spp-1 antibody

Protein level used designations for IBSP

integrin-binding sialoprotein (bone sialoprotein, bone sialoprotein II) , integrin-binding sialoprotein , 59 kDa bone sialic acid-containing protein , BSP , alpha 2 HS-glycoprotein alpha 2 (fetuin) , fetuin-A , glycoprotein PP63 , phosphorylated N-glycoprotein pp63 , bone sialoprotein 2 , bone sialoprotein II , cell-binding sialoprotein , BSP II , integrin binding sialoprotein , Bone sialoprotein 2 , 44 kDa bone phosphoprotein , bone sialoprotein 1 , calcium oxalate crystal growth inhibitor protein , early T-lymphocyte activation 1 protein , minopontin , osteopontin , osteopontin-like protein

471249 Pan troglodytes
609146 Canis lupus familiaris
701835 Macaca mulatta
100192352 Xenopus laevis
100271750 Xenopus (Silurana) tropicalis
100344425 Oryctolagus cuniculus
25373 Rattus norvegicus
15891 Mus musculus
3381 Homo sapiens
24477 Rattus norvegicus
281233 Bos taurus
396071 Gallus gallus
397137 Sus scrofa
20750 Mus musculus
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