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The protein encoded by IBSP is a major structural protein of the bone matrix. Additionally we are shipping Integrin-Binding Sialoprotein Kits (13) and Integrin-Binding Sialoprotein Proteins (6) and many more products for this protein.
Showing 10 out of 82 products:
Human Monoclonal IBSP Primary Antibody for EIA, IHC (fro) - ABIN191977
Ibrahim, Leong, Sanchez-Sweatman, Khokha, Sodek, Tenenbaum, Ganss, Cheifetz: Expression of bone sialoprotein and osteopontin in breast cancer bone metastases. in Clinical & experimental metastasis 2001
Show all 8 references for ABIN191977
Human Polyclonal IBSP Primary Antibody for EIA, FACS - ABIN191813
Karmatschek, Maier, Seibel, Woitge, Ziegler, Armbruster: Improved purification of human bone sialoprotein and development of a homologous radioimmunoassay. in Clinical chemistry 1997
Show all 4 references for ABIN191813
Human Polyclonal IBSP Primary Antibody for IF (p), IHC (p) - ABIN748838
Yang, Hai, Qin, Ti, Shangguan, Zhao, Wiggins, Liu, Feng, Chang, Wang, Liu: Cessation of epithelial Bmp signaling switches the differentiation of crown epithelia to the root lineage in a ?-catenin-dependent manner. in Molecular and cellular biology 2013
Show all 2 references for ABIN748838
Human Polyclonal IBSP Primary Antibody for WB - ABIN658035
Yerges, Klei, Cauley, Roeder, Kammerer, Moffett, Ensrud, Nestlerode, Marshall, Hoffman, Lewis, Lang, Barrett-Connor, Ferrell, Orwoll, Zmuda: High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009
Show all 2 references for ABIN658035
Human Polyclonal IBSP Primary Antibody for WB - ABIN2774907
Barnes, Javed, Waller, Kamal, Hebert, Hassan, Bellahcene, Van Wijnen, Young, Lian, Stein, Gerstenfeld: Osteoblast-related transcription factors Runx2 (Cbfa1/AML3) and MSX2 mediate the expression of bone sialoprotein in human metastatic breast cancer cells. in Cancer research 2003
OPN (show SPP1 Antibodies) produced by hematogenous macrophages induces astrocyte process extension toward the infarct border zone, which may contribute to repair of the ischemic neurovascular unit following stroke
During the priming phase of liver regeneration, osteopontin (show SPP1 Antibodies) enhances the recruitment of macrophages and neutrophils, and triggers hepatocyte proliferation through Kupffer cell-derived IL-6 (show IL6 Antibodies) release and the downstream activation of Stat3 (show STAT3 Antibodies).
OPN (show SPP1 Antibodies) deficiency accelerated the spontaneous development of colitis in mice with disrupted gut (show GUSB Antibodies) microbiota and macrophage phagocytic activity.
mechanical stretch (MS) directly increased OPN (show SPP1 Antibodies) protein expression and secretion in vascular smooth muscle cells.
OPN (show SPP1 Antibodies) may modulate psoriasis-like inflammation through altering lymphocyte distribution in skin and draining lymph nodes and by inducing IL-17 (show IL17A Antibodies) expression of inflammatory T cells.
Osteopontin (show SPP1 Antibodies) is expressed in the oviduct and promotes fertilization and preimplantation embryo development.
BSP (show KLK6 Antibodies) has a role in mouse cementum and craniofacial bone mineralization
OPN (show SPP1 Antibodies) actually contributes to the development of gastric cancer.
Hypergravity promoted OPN (show SPP1 Antibodies) expression in osteoblasts by facilitating focal adhesion assembly, strengthening actin bundles, and increasing Runx2 (show RUNX2 Antibodies) expression.
lentiviral-OPN (show SPP1 Antibodies) short hairpin RNA ameliorates the inflammatory response and bone destruction in mice with collagen-induced arthritis. Therefore, OPN (show SPP1 Antibodies) may be a potential therapeutic target for rheumatoid arthritis.
Two significant SNPs within IBSP, rs1054627 and rs17013181, were associated with BMD (show BEST1 Antibodies) and postmenopausal osteoporosis by the two-stage strategy, and rs17013181 was also significantly associated with serum IBSP levels.
Our results suggest that SSEA (show MPST Antibodies)-4 is a specific cell surface antigen (show CD53 Antibodies) that can be used to identify dental pulp stem cells.
the strong correlation between bone sialoprotein (show CRISP1 Antibodies) and OPN (show SPP1 Antibodies) and papillary thyroid carcinoma suggests a role for BSP (show KLK6 Antibodies) and OPN (show SPP1 Antibodies) in calcification and tumor progression of papillary thyroid carcinoma
oxidized low-density lipoprotein-induced expression dependent on Runx2 (show RUNX2 Antibodies) expression
Bone sialoprotein (show CRISP1 Antibodies) could be a key mediator of the hypertrophic chondrocytes-induced angiogenesis of osteoarthritis.
Current evidence demonstrates that BSP (show KLK6 Antibodies) and OPN (show SPP1 Antibodies), play significant roles in bone metastasis of osteotropic malignancies derived from breast, prostate, lung, thyroid, and multiple myeloma. [review]
High expression of bone sialoprotein (show CRISP1 Antibodies) in breast neoplasms was associated with cytokeratin (show KRT4 Antibodies)-positive cells in bone marrow, but not with lymph node metastasis.
results indicate that FGF2 (show FGF2 Antibodies) increases BSP (show KLK6 Antibodies) transcription by targeting the FRE (show FRZB Antibodies) and AP1 (show FOSB Antibodies) elements in the proximal promoter of the human BSP (show KLK6 Antibodies) gene.
BSP (show KLK6 Antibodies) silencing decreased the integrin alphavbeta3 (show ITGAV Antibodies) and beta3 levels, in turn inhibiting cell migration and invasion and decreasing the ability of the cells to metastasize to bone.
IBSP mRNA is over expressed in carotid atheroma plaque (3.74 fold, p = 1.41E-09) in an intraindividual comparison.
The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor.
integrin-binding sialoprotein (bone sialoprotein, bone sialoprotein II)
, integrin-binding sialoprotein
, 59 kDa bone sialic acid-containing protein
, alpha 2 HS-glycoprotein alpha 2 (fetuin)
, glycoprotein PP63
, phosphorylated N-glycoprotein pp63
, bone sialoprotein 2
, bone sialoprotein II
, cell-binding sialoprotein
, BSP II
, integrin binding sialoprotein
, Bone sialoprotein 2
, 44 kDa bone phosphoprotein
, bone sialoprotein 1
, calcium oxalate crystal growth inhibitor protein
, early T-lymphocyte activation 1 protein
, osteopontin-like protein