anti-Integrin-Binding Sialoprotein (IBSP) Antibodies

The protein encoded by IBSP is a major structural protein of the bone matrix. Additionally we are shipping Integrin-Binding Sialoprotein Kits (15) and Integrin-Binding Sialoprotein Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
IBSP 25373 P24090
IBSP 15891 Q61711
IBSP 3381 P21815
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Top anti-Integrin-Binding Sialoprotein Antibodies at

Showing 10 out of 86 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Dog Rabbit Un-conjugated WB WB Suggested Anti-IBSP Antibody Titration: 1.25ug/mlELISA Titer: 1:62500Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated WB IBSP Antibody (N-term) (ABIN658035) western blot analysis in CEM cell line lysates (35 µg/lane). This demonstrates the IBSP antibody detected the IBSP protein (arrow). 400 μL Log in to see 10 to 11 Days
Human Mouse Un-conjugated EIA, IHC (fro), IF, IHC (p), RIA, WB 0.1 mg Log in to see 6 to 8 Days
Human Chicken Un-conjugated EIA, FACS, IF, IHC (p), RIA, WB 0.1 mg Log in to see 6 to 8 Days
Mouse Rabbit Un-conjugated IHC (p), WB Anti-Bone Sialoprotein antibody, Western blotting Lane 1: Rat Liver Tissue Lysate Lane 2: Rat Brain Tissue Lysate Lane 3: Rat Kidney Tissue Lysate Anti-Bone Sialoprotein antibody, IHC(P) IHC(P): Rat Liver Tissue 100 μg Log in to see 4 to 6 Days
Human Rabbit Un-conjugated IHC (p), WB Anti-Bone Sialoprotein antibody, IHC(P) IHC(P): Human Osteosarcoma Tissue 100 μg Log in to see 4 to 6 Days
Human Rabbit Un-conjugated WB 100 μg Log in to see 7 to 9 Days
Human Rabbit Un-conjugated FACS, IF (p), IHC (p), WB   100 μL Log in to see 3 to 7 Days
Human Rat Un-conjugated EIA, WB 0.1 mg Log in to see 11 to 13 Days
Human Rabbit Un-conjugated ELISA, WB 100 μg Log in to see 2 to 3 Days

IBSP Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Mouse (Murine) , , ,

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Top referenced anti-Integrin-Binding Sialoprotein Antibodies

  1. Human Monoclonal IBSP Primary Antibody for EIA, IHC (fro) - ABIN191977 : Ibrahim, Leong, Sanchez-Sweatman, Khokha, Sodek, Tenenbaum, Ganss, Cheifetz: Expression of bone sialoprotein and osteopontin in breast cancer bone metastases. in Clinical & experimental metastasis 2001 (PubMed)
    Show all 8 references for 191977

  2. Human Polyclonal IBSP Primary Antibody for EIA, FACS - ABIN191813 : Karmatschek, Maier, Seibel, Woitge, Ziegler, Armbruster: Improved purification of human bone sialoprotein and development of a homologous radioimmunoassay. in Clinical chemistry 1997 (PubMed)
    Show all 4 references for 191813

  3. Human Polyclonal IBSP Primary Antibody for FACS, IF (p) - ABIN748838 : Yang, Hai, Qin, Ti, Shangguan, Zhao, Wiggins, Liu, Feng, Chang, Wang, Liu: Cessation of epithelial Bmp signaling switches the differentiation of crown epithelia to the root lineage in a ?-catenin-dependent manner. in Molecular and cellular biology 2013 (PubMed)
    Show all 2 references for 748838

  4. Human Polyclonal IBSP Primary Antibody for WB - ABIN658035 : Yerges, Klei, Cauley, Roeder, Kammerer, Moffett, Ensrud, Nestlerode, Marshall, Hoffman, Lewis, Lang, Barrett-Connor, Ferrell, Orwoll, Zmuda: High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009 (PubMed)
    Show all 2 references for 658035

  5. Dog (Canine) Polyclonal IBSP Primary Antibody for WB - ABIN2774907 : Barnes, Javed, Waller, Kamal, Hebert, Hassan, Bellahcene, Van Wijnen, Young, Lian, Stein, Gerstenfeld: Osteoblast-related transcription factors Runx2 (Cbfa1/AML3) and MSX2 mediate the expression of bone sialoprotein in human metastatic breast cancer cells. in Cancer research 2003 (PubMed)

More Antibodies against Integrin-Binding Sialoprotein Interaction Partners

Mouse (Murine) Integrin-Binding Sialoprotein (IBSP) interaction partners

  1. Bone marrow ablation in BSP (show KLK6 Antibodies)-/- mice is followed by a faster vascular and hematopoietic recolonization, along with lower medullary bone formation. Thus, lack of BSP (show KLK6 Antibodies) affects the interplay between hematopoiesis, angiogenesis, and osteogenesis, maybe in part through higher expression of VEGF (show VEGFA Antibodies) and the angiogenic SIBLING, OPN (show SPP1 Antibodies).

  2. OPN (show SPP1 Antibodies) secreted by follicular CD153 (show TNFSF8 Antibodies)(+) senescence-associated T cells in germinal centers (GCs (show UGCG Antibodies)) promotes a continuous supply of intracellular autoantigens via apoptotic cells, thus playing a key role in the progression of the autoreactive GC reaction and leading to pathogenic autoantibody production in lupus-prone mice.

  3. study demonstrated an anti-tumorigenic role of OPN (show SPP1 Antibodies) in transgenic adenocarcinoma of the mouse prostate (TRAMP (show DPT Antibodies)) development and also suggests that the contribution of OPN (show SPP1 Antibodies) to tumor development depends on the type of tumor as well as the source and isoform of OPN (show SPP1 Antibodies)

  4. These data suggest a critical role for reduced stroma-derived osteopontin for hematopoietic stem cell aging.

  5. Osteopontin (show SPP1 Antibodies) is a key mediator released by senescent pulmonary artery smooth muscle cells and contributes to pulmonary hypertension progression.

  6. Osteopontin (OPN (show SPP1 Antibodies)) plays an anti-inflammatory role in acute gastrointestinal acute graft-versus-host disease (GVHD).

  7. Circulating OPN (show SPP1 Antibodies) levels are upregulated in human and murine acute schistosomiasis.

  8. this study shows that neutrophil accumulation at the site of infection with a mixture of endodontic pathogens is significantly reduced in OPN (show SPP1 Antibodies)-deficient mice, and is accompanied by an increase in bacterial load

  9. OPN (show SPP1 Antibodies) ablation skews macrophage polarization toward a pro-regenerative phenotype.

  10. OPN (show SPP1 Antibodies) induces oxidative stress via the involvement of mitochondria and NOX-4 (show NOX4 Antibodies). It may affect mitochondrial morphology and integrity, at least in part, via the involvement of BIK (show BIK Antibodies).

Human Integrin-Binding Sialoprotein (IBSP) interaction partners

  1. These data indicate that secretome derived from salivary gland cancer cells can influence the expression of two potential biomarkers of oral cancer-namely, bone sialoprotein (show CRISP1 Antibodies) (BSP (show KLK6 Antibodies)) and dentin sialoprotein (DSP (show DSPP Antibodies))-in normal salivary gland cells.

  2. In conclusion, serum levels of BSP (show KLK6 Antibodies), ALP (show ALP Antibodies), ICTP, and PSA (show PLAG1 Antibodies) increased in patients with bone metastases, and combined detection of all markers could improve the positive-predictive value.

  3. Preameloblast-Derived Factors Mediate Osteoblast Differentiation of Human Bone Marrow Mesenchymal Stem Cells by Runx2 (show RUNX2 Antibodies)-Osterix (show SP7 Antibodies)-BSP (show KLK6 Antibodies) Signaling.

  4. Two significant SNPs within IBSP, rs1054627 and rs17013181, were associated with BMD (show BEST1 Antibodies) and postmenopausal osteoporosis by the two-stage strategy, and rs17013181 was also significantly associated with serum IBSP levels.

  5. Our results suggest that SSEA (show MPST Antibodies)-4 is a specific cell surface antigen (show CD53 Antibodies) that can be used to identify dental pulp stem cells.

  6. the strong correlation between bone sialoprotein (show CRISP1 Antibodies) and OPN (show SPP1 Antibodies) and papillary thyroid carcinoma suggests a role for BSP (show KLK6 Antibodies) and OPN (show SPP1 Antibodies) in calcification and tumor progression of papillary thyroid carcinoma

  7. oxidized low-density lipoprotein-induced expression dependent on Runx2 (show RUNX2 Antibodies) expression

  8. Bone sialoprotein (show CRISP1 Antibodies) could be a key mediator of the hypertrophic chondrocytes-induced angiogenesis of osteoarthritis.

  9. Current evidence demonstrates that BSP (show KLK6 Antibodies) and OPN (show SPP1 Antibodies), play significant roles in bone metastasis of osteotropic malignancies derived from breast, prostate, lung, thyroid, and multiple myeloma. [review]

  10. High expression of bone sialoprotein (show CRISP1 Antibodies) in breast neoplasms was associated with cytokeratin (show KRT4 Antibodies)-positive cells in bone marrow, but not with lymph node metastasis.

Integrin-Binding Sialoprotein (IBSP) Antigen Profile

Protein Summary

The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor.

Gene names and symbols associated with IBSP

  • integrin-binding sialoprotein (IBSP) antibody
  • integrin-binding sialoprotein (ibsp) antibody
  • integrin-binding sialoprotein (LOC100344425) antibody
  • alpha-2-HS-glycoprotein (Ahsg) antibody
  • integrin binding sialoprotein (Ibsp) antibody
  • integrin-binding sialoprotein (Ibsp) antibody
  • secreted phosphoprotein 1 (Spp1) antibody
  • 2AR antibody
  • Aa2-066 antibody
  • Apl-1 antibody
  • BNSP antibody
  • Bsp antibody
  • BSP-II antibody
  • Bsp2 antibody
  • BSPI antibody
  • BSP II antibody
  • BSPII antibody
  • Eta antibody
  • ETA-1 antibody
  • IBSP antibody
  • OP antibody
  • Opn antibody
  • Opnl antibody
  • pp63 antibody
  • Ric antibody
  • SP-II antibody
  • Spp-1 antibody

Protein level used designations for IBSP

integrin-binding sialoprotein (bone sialoprotein, bone sialoprotein II) , integrin-binding sialoprotein , 59 kDa bone sialic acid-containing protein , BSP , alpha 2 HS-glycoprotein alpha 2 (fetuin) , fetuin-A , glycoprotein PP63 , phosphorylated N-glycoprotein pp63 , bone sialoprotein 2 , bone sialoprotein II , cell-binding sialoprotein , BSP II , integrin binding sialoprotein , Bone sialoprotein 2 , 44 kDa bone phosphoprotein , bone sialoprotein 1 , calcium oxalate crystal growth inhibitor protein , early T-lymphocyte activation 1 protein , minopontin , osteopontin , osteopontin-like protein

471249 Pan troglodytes
609146 Canis lupus familiaris
701835 Macaca mulatta
100192352 Xenopus laevis
100271750 Xenopus (Silurana) tropicalis
100344425 Oryctolagus cuniculus
25373 Rattus norvegicus
15891 Mus musculus
3381 Homo sapiens
24477 Rattus norvegicus
281233 Bos taurus
396071 Gallus gallus
397137 Sus scrofa
20750 Mus musculus
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