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The protein encoded by IBSP is a major structural protein of the bone matrix. Additionally we are shipping Integrin-Binding Sialoprotein Kits (15) and Integrin-Binding Sialoprotein Proteins (7) and many more products for this protein.
Showing 10 out of 86 products:
Human Monoclonal IBSP Primary Antibody for EIA, IHC (fro) - ABIN191977
Ibrahim, Leong, Sanchez-Sweatman, Khokha, Sodek, Tenenbaum, Ganss, Cheifetz: Expression of bone sialoprotein and osteopontin in breast cancer bone metastases. in Clinical & experimental metastasis 2001
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Human Polyclonal IBSP Primary Antibody for EIA, FACS - ABIN191813
Karmatschek, Maier, Seibel, Woitge, Ziegler, Armbruster: Improved purification of human bone sialoprotein and development of a homologous radioimmunoassay. in Clinical chemistry 1997
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Human Polyclonal IBSP Primary Antibody for FACS, IF (p) - ABIN748838
Yang, Hai, Qin, Ti, Shangguan, Zhao, Wiggins, Liu, Feng, Chang, Wang, Liu: Cessation of epithelial Bmp signaling switches the differentiation of crown epithelia to the root lineage in a ?-catenin-dependent manner. in Molecular and cellular biology 2013
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Human Polyclonal IBSP Primary Antibody for WB - ABIN658035
Yerges, Klei, Cauley, Roeder, Kammerer, Moffett, Ensrud, Nestlerode, Marshall, Hoffman, Lewis, Lang, Barrett-Connor, Ferrell, Orwoll, Zmuda: High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009
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Dog (Canine) Polyclonal IBSP Primary Antibody for WB - ABIN2774907
Barnes, Javed, Waller, Kamal, Hebert, Hassan, Bellahcene, Van Wijnen, Young, Lian, Stein, Gerstenfeld: Osteoblast-related transcription factors Runx2 (Cbfa1/AML3) and MSX2 mediate the expression of bone sialoprotein in human metastatic breast cancer cells. in Cancer research 2003
Bone marrow ablation in BSP (show KLK6 Antibodies)-/- mice is followed by a faster vascular and hematopoietic recolonization, along with lower medullary bone formation. Thus, lack of BSP (show KLK6 Antibodies) affects the interplay between hematopoiesis, angiogenesis, and osteogenesis, maybe in part through higher expression of VEGF (show VEGFA Antibodies) and the angiogenic SIBLING, OPN (show SPP1 Antibodies).
OPN (show SPP1 Antibodies) secreted by follicular CD153 (show TNFSF8 Antibodies)(+) senescence-associated T cells in germinal centers (GCs (show UGCG Antibodies)) promotes a continuous supply of intracellular autoantigens via apoptotic cells, thus playing a key role in the progression of the autoreactive GC reaction and leading to pathogenic autoantibody production in lupus-prone mice.
study demonstrated an anti-tumorigenic role of OPN (show SPP1 Antibodies) in transgenic adenocarcinoma of the mouse prostate (TRAMP (show DPT Antibodies)) development and also suggests that the contribution of OPN (show SPP1 Antibodies) to tumor development depends on the type of tumor as well as the source and isoform of OPN (show SPP1 Antibodies)
These data suggest a critical role for reduced stroma-derived osteopontin for hematopoietic stem cell aging.
Osteopontin (show SPP1 Antibodies) is a key mediator released by senescent pulmonary artery smooth muscle cells and contributes to pulmonary hypertension progression.
Osteopontin (OPN (show SPP1 Antibodies)) plays an anti-inflammatory role in acute gastrointestinal acute graft-versus-host disease (GVHD).
Circulating OPN (show SPP1 Antibodies) levels are upregulated in human and murine acute schistosomiasis.
this study shows that neutrophil accumulation at the site of infection with a mixture of endodontic pathogens is significantly reduced in OPN (show SPP1 Antibodies)-deficient mice, and is accompanied by an increase in bacterial load
OPN (show SPP1 Antibodies) ablation skews macrophage polarization toward a pro-regenerative phenotype.
OPN (show SPP1 Antibodies) induces oxidative stress via the involvement of mitochondria and NOX-4 (show NOX4 Antibodies). It may affect mitochondrial morphology and integrity, at least in part, via the involvement of BIK (show BIK Antibodies).
These data indicate that secretome derived from salivary gland cancer cells can influence the expression of two potential biomarkers of oral cancer-namely, bone sialoprotein (show CRISP1 Antibodies) (BSP (show KLK6 Antibodies)) and dentin sialoprotein (DSP (show DSPP Antibodies))-in normal salivary gland cells.
In conclusion, serum levels of BSP (show KLK6 Antibodies), ALP (show ALP Antibodies), ICTP, and PSA (show PLAG1 Antibodies) increased in patients with bone metastases, and combined detection of all markers could improve the positive-predictive value.
Preameloblast-Derived Factors Mediate Osteoblast Differentiation of Human Bone Marrow Mesenchymal Stem Cells by Runx2 (show RUNX2 Antibodies)-Osterix (show SP7 Antibodies)-BSP (show KLK6 Antibodies) Signaling.
Two significant SNPs within IBSP, rs1054627 and rs17013181, were associated with BMD (show BEST1 Antibodies) and postmenopausal osteoporosis by the two-stage strategy, and rs17013181 was also significantly associated with serum IBSP levels.
Our results suggest that SSEA (show MPST Antibodies)-4 is a specific cell surface antigen (show CD53 Antibodies) that can be used to identify dental pulp stem cells.
the strong correlation between bone sialoprotein (show CRISP1 Antibodies) and OPN (show SPP1 Antibodies) and papillary thyroid carcinoma suggests a role for BSP (show KLK6 Antibodies) and OPN (show SPP1 Antibodies) in calcification and tumor progression of papillary thyroid carcinoma
oxidized low-density lipoprotein-induced expression dependent on Runx2 (show RUNX2 Antibodies) expression
Bone sialoprotein (show CRISP1 Antibodies) could be a key mediator of the hypertrophic chondrocytes-induced angiogenesis of osteoarthritis.
Current evidence demonstrates that BSP (show KLK6 Antibodies) and OPN (show SPP1 Antibodies), play significant roles in bone metastasis of osteotropic malignancies derived from breast, prostate, lung, thyroid, and multiple myeloma. [review]
High expression of bone sialoprotein (show CRISP1 Antibodies) in breast neoplasms was associated with cytokeratin (show KRT4 Antibodies)-positive cells in bone marrow, but not with lymph node metastasis.
The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor.
integrin-binding sialoprotein (bone sialoprotein, bone sialoprotein II)
, integrin-binding sialoprotein
, 59 kDa bone sialic acid-containing protein
, alpha 2 HS-glycoprotein alpha 2 (fetuin)
, glycoprotein PP63
, phosphorylated N-glycoprotein pp63
, bone sialoprotein 2
, bone sialoprotein II
, cell-binding sialoprotein
, BSP II
, integrin binding sialoprotein
, Bone sialoprotein 2
, 44 kDa bone phosphoprotein
, bone sialoprotein 1
, calcium oxalate crystal growth inhibitor protein
, early T-lymphocyte activation 1 protein
, osteopontin-like protein