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The protein encoded by IL27 is one of the subunits of a heterodimeric cytokine complex. Additionally we are shipping Interleukin 27 Antibodies (143) and Interleukin 27 Proteins (27) and many more products for this protein.
Showing 10 out of 45 products:
Mouse (Murine) IL27 ELISA Kit for Sandwich ELISA - ABIN1672803
Larousserie, Charlot, Bardel, Froger, Kastelein, Devergne: Differential effects of IL-27 on human B cell subsets. in Journal of immunology (Baltimore, Md. : 1950) 2006
Show all 3 references for ABIN1672803
Human IL27 ELISA Kit for Sandwich ELISA - ABIN1672802
Larousserie, Bardel, Pflanz, Arnulf, Lome-Maldonado, Hermine, Brégeaud, Perennec, Brousse, Kastelein, Devergne: Analysis of interleukin-27 (EBI3/p28) expression in Epstein-Barr virus- and human T-cell leukemia virus type 1-associated lymphomas: heterogeneous expression of EBI3 subunit by tumoral cells. in The American journal of pathology 2005
The Serum IL-27 levels were negatively correlated with neuromyelitis optica spectrum disorders severity and spinal cord lesion length.
IL-27 gene rs153109 A/G SNP may be involved in susceptibility to BD in the Iranian population.
Serum IL-27 and IL-27-producing T cells, are involved in the pathogenesis of pemphigus.
The level of interleukin 27 is increased in peripheral blood mononuclear cells of patients with rheumatoid arthritis or osteoarthritis.
role of IL-27 in inflammation, cancer development and regulation and differentiation of immune cells.
The B cell response to IL-27 is modulated during B cell differentiation and varies depending on the mode of B cell activation (show BLNK ELISA Kits).
data showed that progressive MS patients had decreased plasma and mRNA expression levels of IL-27, suggesting that it might be involved in the pathophysiological process of multiple sclerosis
The rs153109 and rs17855750 IL-27 polymorphisms were associated with increased risk for renal cell carcinoma, suggesting an important role of IL-27 in nephrocarcinogenesis.
The results of the present study clearly demonstrate that the STAT3 (show STAT3 ELISA Kits) pathway triggered by anti-inflammatory IL-27 plays a role in protecting cardiomyocytes against GSC (show GSC ELISA Kits)-mediated damage.
study shows that IL-27 rs17855750 polymorphism is significantly associated with increased susceptibility to cancer in Chinese
IL-27 is one of the limited unique cytokines directly acting on hematopoietic stem cells (HSCs) to promote differentiation into myeloid progenitors during emergency myelopoiesis.
These results provide the first evidences that Fli-1 (show FLI1 ELISA Kits) positively regulates LPS (show TLR4 ELISA Kits)-induced IL-27 production in macrophages
of autocrine/paracrine mechanisms involving IL-27 in adipocytes under conditions of inflammatory stress that may link obesity with inflammatory diseases.
Increased IL-27 expression in bleomycin-induced pulmonary fibrosis was noted.
IL-27 induces the endothelial differentiation in cardiac resident stem cells through STAT3 (show STAT3 ELISA Kits)/Pim-1 (show PIM1 ELISA Kits) signaling pathway.
demonstrate that suppression mediated by interferon (show IFNA ELISA Kits) and IL-27 is a negative feedback mechanism for group 2 innate lymphoid cells function in vivo
Natural killer cells-dendritic cells interaction elicits a positive feedback loop for IFN-gamma (show IFNG ELISA Kits) and IL-27 production.
demonstrate the essential role of IL-27 signaling in regulating immune responses to extracellular protozoan infections
IL-27 regulates enhanced susceptibility to S. aureus pneumonia following influenza infection, potentially through the induction of IL-10 (show IL10 ELISA Kits) and suppression of IL-17 (show IL17A ELISA Kits).
These data identify an IL-27/NFIL3 (show NFIL3 ELISA Kits) signalling axis as a key regulator of effector T-cell responses via induction of Tim-3 (show HAVCR2 ELISA Kits), IL-10 (show IL10 ELISA Kits) and T-cell dysfunction.
The open reading frame of IL-27 p28 gene is 720 bp, which encodes a protein of 239 amino acids with a predicted molecular mass of 26.6 kDa. The deduced amino acid sequence of IL-27 p28 showed a high degree of homology to human (63%) and mouse (58%).
The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR).
, IL-27 p28 subunit
, IL-27 subunit alpha
, interleukin 30
, interleukin-27 subunit alpha
, interleukin 27 p28 subunit
, interluekin 27