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NK2 Homeobox 5 Proteins (NKX2-5)

NKX2-5 encodes a homeobox-containing transcription factor. Additionally we are shipping NK2 Homeobox 5 Antibodies (122) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NKX2-5 1482 P52952
NKX2-5 18091 P42582
NKX2-5 114109 O35767
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Top NK2 Homeobox 5 Proteins at

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 19 Days

NKX2-5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Mouse (Murine)

Rat (Rattus)

More Proteins for NK2 Homeobox 5 (NKX2-5) Interaction Partners

Human NK2 Homeobox 5 (NKX2-5) interaction partners

  1. the frequency of NKX2.5 gene mutations among the patient with Atrial septal defect: in 80% of the affected individuals two polymorphic sites are located at position 487 and 495.

  2. The crystal structure and binding domains were identified in cardiac NKX2.5.

  3. We describe in this study the mutational and expression analysis of the NKX2.5 gene in nonsyndromic CHD (show CHDH Proteins) patients

  4. NKX2.5 mutations were not found. The c.63A>G polymorphism might be associated with thyroid hypoplasia.

  5. Our findings demonstrate that somatic NKX2-5 mutations do not represent an important aetiologic pathway in Chinese children with congenital heart disease.

  6. Combined expression of NKX2-5, HAND1 (show HAND1 Proteins), and NOTCH1 (show NOTCH1 Proteins) coordinately contribute to cardiac malformations in Hhypoplastic left heart syndrome.

  7. The novel DSV (1500G>C) of NKX2-5 gene (show GPD1 Proteins) may contribute to a small number of VSD, and rs2277923 SNP may contribute to the risk of sporadic ASD (show ARSD Proteins) in Chinese Yunnan population.

  8. Nkx2-5 (and Isl1 (show ISL1 Proteins)) regulate the specification of cardiac progenitor cells and acquisition of cardiomyocyte subtype identity.

  9. Germline mutations in the NKX2-5, GATA4 (show GATA4 Proteins), and CRELD1 (show CRELD1 Proteins) genes do not appear to be associated with CHD (show CHDH Proteins) in Mexican DS patients.

  10. NKX2-5 is thus responsible for dominant familial ASD (show ARSD Proteins) even in consanguineous populations, and a wide genetic and phenotypic diversity is characteristic of NKX2-5 mutations in the Lebanese population.

Mouse (Murine) NK2 Homeobox 5 (NKX2-5) interaction partners

  1. In the absence of NKX2-5 (or Smad-6 (show SMAD6 Proteins)), a severe form of rheumatic heart disease is observed.

  2. Study reports extensive and complex interdependent genomic occupancy of TBX5 (show TBX5 Proteins), NKX2-5, and the zinc finger TF GATA4 (show GATA4 Proteins) coordinately controlling cardiac gene expression, differentiation, and morphogenesis.

  3. Sequential binding of MEIS1 (show MEIS1 Proteins) and NKX2-5 on the Popdc2 (show POPDC2 Proteins) gene demonstrate a mechanism for spatiotemporal regulation of enhancers during cardiogenesis.

  4. The model proposed will help to elucidate the molecular basis for disease causing mutations in GATA4 and NKX2-5 and may be relevant to other members of the GATA and NK classes of transcription factors.

  5. MSCs thus form a 'mechanical memory' of rigidity by progressively suppressing NKX2.5, thereby elevating SMA (show SMN1 Proteins) in a scar-like state.

  6. the Shox2 (show SHOX2 Proteins)-Nkx2-5 antagonistic mechanism primes the pacemaker cell fate in the pulmonary vein myocardium and sinoatrial node

  7. Findings implicate a novel, temporal-specific role of Mzf1 (show ZSCAN1 Proteins) in embryonic heart development and show that Mzf1 (show ZSCAN1 Proteins) bounds directly to the Nkx2.5 during murine embryonic stem cell differentiation.

  8. A heterozygous Nkx2-5 missense mutation in the homeodomain demonstrates a high penetrance of diverse cardiac anomalies, similar to or more profound than those observed in human patients.

  9. our findings reveal a novel mechanism for regulation of SCFFbox25-dependent Nkx2-5 and Tbx5 (show TBX5 Proteins) ubiquitination in cardiac development and provide a new insight into the regulatory mechanism of Nkx2-5 and Tbx5 (show TBX5 Proteins) transcriptional activity.

  10. Results show that NKX2-5 mRNA levels correlate with muscle histopathology in mice and humans and find that NKX2-5 levels modify disease phenotypes in mice with RNA toxicity.

NK2 Homeobox 5 (NKX2-5) Protein Profile

Protein Summary

This gene encodes a homeobox-containing transcription factor. This transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot, which are both heart malformation diseases. Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with NK2 Homeobox 5 Proteins (NKX2-5)

  • NK2 transcription factor related, locus 5 (Drosophila) (NKX2-5)
  • Nkx2.5 protein (nkx2.5)
  • NK2 transcription factor related, locus 5 (nkx2-5)
  • NK2 homeobox 5 (NKX2-5)
  • NK2 homeobox 5 (Nkx2-5)
  • Nkx-2.5 homeobox protein (NKX-2.5)
  • CHNG5 protein
  • CNKX-2.5 protein
  • Csx protein
  • CSX1 protein
  • HLHS2 protein
  • NKX-2.5 protein
  • Nkx2-5 protein
  • NKX2.5 protein
  • NKX2E protein
  • NKX4-1 protein
  • tinman protein
  • VSD3 protein
  • XNkx-2.5 protein
  • XNkx2-5 protein

Protein level used designations for NK2 Homeobox 5 Proteins (NKX2-5)

NK2 transcription factor related, locus 5 (Drosophila) , NK2 transcription factor locus 5-like , Nkx2.5 protein , NK2 transcription factor related, locus 5 , cardiac-specific homeobox 1 , homeobox protein CSX , homeobox protein NK-2 homolog E , homeobox protein Nkx-2.5 , tinman paralog , transcription factor NKX2.5 , Drosophila NK2 transcription factor related, locus 5 , cardiac-specific homeobox , rNKx-2.5

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