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Nemo-Like Kinase Proteins (NLK)

Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Additionally we are shipping Nemo-Like Kinase Antibodies (105) and Nemo-Like Kinase Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NLK 14751 P06745
NLK 292804 Q6P6V0
NLK 51701 Q9UBE8
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Top Nemo-Like Kinase Proteins at

Showing 8 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Baculovirus infected Insect Cells Human His tag,GST tag 50 μg Log in to see 16 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

NLK Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus)

Human , , ,
, ,

Top referenced Nemo-Like Kinase Proteins

  1. Human NLK Protein expressed in Wheat germ - ABIN1312656 : Shaw-Hallgren, Chmielarska Masoumi, Zarrizi, Hellman, Karlsson, Helou, Massoumi: Association of nuclear-localized Nemo-like kinase with heat-shock protein 27 inhibits apoptosis in human breast cancer cells. in PLoS ONE 2014 (PubMed)

More Proteins for Nemo-Like Kinase (NLK) Interaction Partners

Mouse (Murine) Nemo-Like Kinase (NLK) interaction partners

  1. NLK can phosphorylate the mutant polyglutamine-expanded androgen receptor (show AR Proteins) protein, enhance its aggregation, and promote androgen receptor (show AR Proteins)-dependent gene transcription by regulating androgen receptor (show AR Proteins)-cofactor interactions.

  2. Nlk is a negative regulator of skeletal homeostasis.

  3. PGI (show BGN Proteins) is a moonlighting protein that functions as a cytosolic enzyme involved in glycolysis and gluconeogenesis, and as cytokine through binding to its cell surface receptor.

  4. The mGPI-transgenic mice presented GPI (show GPI Proteins) more efficiently and showed a dramatic increase in negative selection and an inhibition of arthritis.

  5. either reducing NLK enzymatic activity or decreasing NLK expression levels can have beneficial effects against the toxicity induced by polyglutamine-expanded ATXN1 (show ATXN1 Proteins)

  6. Increased red cell turnover in a line of CD22 (show CD22 Proteins)-deficient mice is caused by Gpi1c: a model for hereditary haemolytic anaemia.

  7. NEMO (show IKBKG Proteins) binding domain peptide treatment results in improved generation of specific force and greater resistance to lengthening activations in dystrophic diaphragm muscle ex vivo.

  8. Nlk suppresses osteoblastogenesis by opposing BMP/Smad (show SMAD1 Proteins) and WNT (show WNT2 Proteins) canonical signaling

  9. Data show that silencing of AMF/PGI (show GPI Proteins) induced MET and suppressed the tumor growth and pulmonary metastasis of LM8 cells in nude mice.

  10. Wnt3a (show WNT3A Proteins) stimulation led to an increase in the interaction of TAB2 (show TAB2 Proteins) with NLK and the formation of a TAK1 (show NR2C2 Proteins).TAB2 (show TAB2 Proteins).NLK complex, suggesting that this TAK1 (show NR2C2 Proteins)-TAB2 (show TAB2 Proteins)-NLK pathway may constitute a negative feedback mechanism for canonical Wnt (show WNT2 Proteins) signaling.

Zebrafish Nemo-Like Kinase (NLK) interaction partners

  1. NLK negatively regulates Notch (show NOTCH1 Proteins)-dependent transcriptional activation by phosphorylating Notch1ICD. Phosphorylated Notch1ICD is impaired in its ability to form a transcriptionally active ternary complex.

  2. nlk strongly enhances convergent/extension phenotypes, suggesting a role in modulating cell movements as well as cell fate.

Xenopus laevis Nemo-Like Kinase (NLK) interaction partners

  1. NLK1 acts as a kinase by catalyzing phosphorylation of pumilio (Pum)1, Pum2, and cytoplasmic polyadenylation element binding protein 1 (CPEB) to regulate translation of mRNAs, including cyclin B1 mRNA, stored in oocytes.

  2. These results provide the first evidence that p38 (show MAPK14 Proteins) specifically regulates NLK function, which is required for anterior formation in Xenopus development.

Human Nemo-Like Kinase (NLK) interaction partners

  1. Our results suggest that NLK inhibits transcriptional activation of Nurr1 (show NR4A2 Proteins) gene by impeding CBP's role as a co-activator of NF-kappaB (show NFKB1 Proteins) and CREB (show CREB1 Proteins) in prostate cancer.

  2. The expression of NLK was negatively correlated with TCF4 (show TCF4 Proteins) expression in lung cancers

  3. NLK overexpression is an independent prognostic factor in colorectal cancer and knockdown of NLK expression inhibits colorectal cancer progression and metastasis.

  4. Further experiments demonstrated that the overexpression of miR3623p resulted in decrease expression levels of nemo-like kinase

  5. NLK was involved in miR (show MLXIP Proteins)-92b-induced cell proliferation, and its protein level was obviously downregulated in the miR (show MLXIP Proteins)-92b-overexpressing xenograft tumors.

  6. Data show that metformin inhibits nemo like kinase (NLK) expression and might be a potential treatment strategy for non-small cell lung cancer (NSCLC).

  7. Down-regulation of NLK inhibited tumorigenesis and up-regulated the expression of cell cycle proteins in laryngeal cancer cells.

  8. In this review, we will make a summary on the comprehensive roles of NLK in the regulation of various cancers

  9. NLK was an identified miR (show MLXIP Proteins)-199a-3p target gene and functioned as a tumor suppressor gene in colorectal cancer.

  10. NLK overexpression is associated with poor overall survival in patients with hepatocellular carcinoma(HCC (show FAM126A Proteins)), it might be an independent poor prognostic marker for HCC (show FAM126A Proteins).

Pig (Porcine) Nemo-Like Kinase (NLK) interaction partners

  1. These data show that porcine epidemic diarrhea virus nsp5 (show SPECC1 Proteins) disrupts type I interferon (show IFNA Proteins) signaling by cleaving NEMO (show IKBKG Proteins).

Nemo-Like Kinase (NLK) Protein Profile

Protein Summary

Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK- SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhibits adipogenesis and promotes osteoblastogenesis in mesenchymal stem cells (MSCs). Negative regulator of the canonical Wnt/beta-catenin signaling pathway. Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1. Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes. Negative regulator of the Notch signaling pathway. Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1. Negative regulator of the MYB family of transcription factors. Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 and MYBL2 inhibits their interaction with the coactivator CREBBP. Other transcription factors may also be inhibited by direct phosphorylation of CREBBP itself. Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which is in turn required for activation of NLK by MAP3K7/TAK1 (By similarity).

Gene names and symbols associated with Nemo-Like Kinase Proteins (NLK)

  • glucose phosphate isomerase 1 (Gpi1)
  • nemo-like kinase (NLK)
  • nemo like kinase, type 1 (nlk1)
  • nemo-like kinase (nlk)
  • Nemo-like kinase (NLK)
  • Nemo-Like kinase (nemo-like)
  • glucose-6-phosphate isomerase (Gpi)
  • nemo like kinase (Nlk)
  • AI194375 protein
  • Amf protein
  • Gpi protein
  • Gpi-1 protein
  • Gpi-1r protein
  • Gpi-1s protein
  • Gpi-1t protein
  • Gpi1 protein
  • Gpi1-r protein
  • Gpi1-s protein
  • Gpi1-t protein
  • Gpi1s protein
  • MF protein
  • nemo-like protein
  • NK protein
  • NK/GPI protein
  • NLK protein
  • nlk1 protein
  • nlk2 protein
  • nlkb protein
  • Org protein
  • RGD1561602 protein
  • Xnlk protein
  • zgc:111875 protein

Protein level used designations for Nemo-Like Kinase Proteins (NLK)

NLK , PGI , PHI , autocrine motility factor , glucose phosphate isomerase 1 complex , glucose phosphate isomerase 1, regulatory , glucose phosphate isomerase 1, structural , glucose phosphate isomerase 1, temporal , glucose-6-phosphate isomerase , maturation factor , neuroleukin , phosphoglucose isomerase , phosphohexose isomerase , structural glucose phosphate isomerase 1 , nemo like kinase b , nemo-like kinase , nemo-like kinase 2 , Nemo-like kinase , nemo like kinase , Nemo-Like kinase , serine/threonine-protein kinase NLK-like , glucose phosphate isomerase , serine/threonine protein kinase NLK , serine/threonine-protein kinase NLK , Serine/threonine-protein kinase NLK

14751 Mus musculus
100058876 Equus caballus
405892 Danio rerio
414522 Xenopus laevis
445934 Takifugu rubripes
677693 Macaca mulatta
739132 Pan troglodytes
778685 Ciona intestinalis
100019356 Monodelphis domestica
100144638 Xenopus (Silurana) tropicalis
100348930 Oryctolagus cuniculus
100414864 Callithrix jacchus
100469296 Ailuropoda melanoleuca
100560802 Anolis carolinensis
100593981 Nomascus leucogenys
292804 Rattus norvegicus
18099 Mus musculus
497961 Rattus norvegicus
51701 Homo sapiens
507204 Bos taurus
491160 Canis lupus familiaris
417669 Gallus gallus
100511657 Sus scrofa
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