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Neuropilin 1 Proteins (NRP1)

NRP1 encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Additionally we are shipping Neuropilin 1 Antibodies (256) and Neuropilin 1 Kits (41) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NRP1 8829 O14786
NRP1 18186 P97333
NRP1 246331 Q9QWJ9
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Top Neuropilin 1 Proteins at

Showing 10 out of 37 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human Fc Tag Human Neuropilin-1, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. Immobilized Human Neuropilin-1, Fc Tag (Cat # NR1-H5252) at 2 μg/mL (100 μL/well) can bind Biotinylated Human VEGF165 (Cat # VE5-H8210) with a linear range of 5-40 ng/mL. 50 μg Log in to see 2 to 3 Days
HOST_Human Cells Human His tag 50 μg Log in to see 16 Days
HOST_Human Cells Cynomolgus Un-conjugated 50 μg Log in to see 16 Days
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
HOST_HEK-293 Cells Human His tag 10 μg Log in to see 2 to 3 Days
HOST_Escherichia coli (E. coli) Rat His tag,MBP tag 100 μg Log in to see 11 to 13 Days
HOST_HEK-293 Human His tag   0.05 mg Log in to see 2 to 3 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_HEK-293 Human Fc Tag   0.05 mg Log in to see 2 to 3 Days

NRP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, , ,
Mouse (Murine) ,
Rat (Rattus)

Top referenced Neuropilin 1 Proteins

  1. Human Neuropilin 1 Protein expressed in Human Cells - ABIN2001892 : He, Tessier-Lavigne: Neuropilin is a receptor for the axonal chemorepellent Semaphorin III. in Cell 1997 (PubMed)
    Show all 7 references for ABIN2001892

  2. Cynomolgus Neuropilin 1 Protein expressed in Human Cells - ABIN2010114 : Soker, Takashima, Miao, Neufeld, Klagsbrun: Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. in Cell 1998 (PubMed)
    Show all 5 references for ABIN2010114

  3. Human Neuropilin 1 Protein expressed in HEK-293 Cells - ABIN2181550 : Tamagnone, Artigiani, Chen, He, Ming, Song, Chedotal, Winberg, Goodman, Poo, Tessier-Lavigne, Comoglio: Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. in Cell 1999 (PubMed)
    Show all 2 references for ABIN2181550

More Proteins for Neuropilin 1 (NRP1) Interaction Partners

Human Neuropilin 1 (NRP1) interaction partners

  1. This review provides a general overview of current knowledge of the signalling pathways that are modulated by NRP1 (show NELL1 Proteins), with particular focus on neuronal and vascular roles in the brain and retina.

  2. This study suggests that NRP1 (show NELL1 Proteins) expression and LVD are independent factors that are likely to predict the risk of LN metastasis in squamous cell carcinoma (SCC (show CYP11A1 Proteins))of the tongue, whereas the expression of VEGFC (show VEGFC Proteins), VEGFR3 (show FLT4 Proteins), CCR7 (show CCR7 Proteins), and SEMA3E (show SEMA3E Proteins) are nonindependent predictive factors

  3. Curcumin-loaded nanoliposomes linked to homing peptides for integrin targeting and neuropilin-1-mediated internalization reduced viability of breast cancer cells.

  4. Upregulated expression of NRP1 (show NELL1 Proteins) is associated with glioma.

  5. Studies suggest that the activation of NRP-1 (show NELL1 Proteins) by PlGF (show PGF Proteins) directly contributes to tumour aggressiveness and to melanoma escape from anti-VEGF-A (show VEGFA Proteins) therapies.

  6. REVIEW: Nrp1 (show NELL1 Proteins) functions in the vasculature is critical for the development of targeted therapeutics for cancer and vascular diseases such as atherosclerosis and retinopathies.

  7. High Expression of Neuropilin-1 Associates with Hepatocellular Carcinoma.

  8. Increased NRP-1 (show NELL1 Proteins) expression is associated with metastatic endometrial and lung cancers.

  9. miR (show MLXIP Proteins)-152 suppression in NSCLC cells might promote neuropilin-1 mediated cancer metastasis.

  10. NRP-1 (show NELL1 Proteins) was found to be overexpressed in gastric cancer (GC) tissues, and its expression correlates with the clinical staging, tumor differentiation and pathological types of gastric cancer.

Mouse (Murine) Neuropilin 1 (NRP1) interaction partners

  1. IL-10 (show IL10 Proteins) abrogation efficiently induces regulatory T cell (Treg) formation but dampens tumoral neuropilin-1 (Nrp-1) Treg signaling, which simultaneously augments Th1 (show HAND1 Proteins) and Th17 immunity.

  2. that microglial expression of Neuropilin-1 (Nrp1) is required for tuftsin-driven amelioration of EAE symptoms

  3. Sepsis per se markedly promoted the expression of Nrp-1 of CD4 (show CD4 Proteins)(+)CD25 (show IL2RA Proteins)(+)Tregs. Foxp-3 (show FOXP3 Proteins)/CTLA-4 (show CTLA4 Proteins)/TGF-beta (show TGFB1 Proteins)(m+) of Nrp-1(high)Tregs were upregulated by septic challenge.

  4. Both placental NRP1 and VEGF were expressed at lower levels in women with pre-eclampsia and homocysteine-treated mice, which may contribute to endothelial damage.

  5. suppression of beta3-integrin (show ITGB3 Proteins) in mice leads to the activation of a neuropilin-1 (NRP1)-dependent cell migration pathway in endothelial cells via a mechanism that depends on NRP1's mobilisation away from mature focal adhesions following VEGF (show VEGFA Proteins)-stimulation

  6. The results show that high vs. low expression of Nrp-1 or Helios (show ZNFN1A2 Proteins) does not unequivocally identify Treg clones of thymic or peripheral origin.

  7. Nrp1 in endothelial cells suppresses TGFbeta (show TGFB1 Proteins) activation and signaling by forming intercellular protein complexes with beta8 integrin.

  8. In vascular sprouting, neuropilin-1 suppresses the stalk-cell phenotype by limiting Smad2 (show SMAD2 Proteins)/3 activation through Alk1 (show ACVRL1 Proteins) and Alk5 (show TGFBR1 Proteins). Notch (show NOTCH1 Proteins) downregulates Nrp1, thus relieving the inhibition of Alk1 (show ACVRL1 Proteins) and Alk5 (show TGFBR1 Proteins), thereby driving stalk-cell behaviour.

  9. NRP1 enables ECM (show MMRN1 Proteins)-induced filopodia formation for tip cell function during sprouting angiogenesis.

  10. demonstrate that in mice on the C57Bl/6 background EMX1 (show EMX1 Proteins) plays an essential role in the midline crossing of an axonal subpopulation of the corpus callosum derived from the anterior cingulate cortex. In the absence of EMX1 (show EMX1 Proteins), cingulate axons display reduced expression of the axon guidance receptor NRP1 and form aberrant axonal bundles within the rostral corpus callosum.

Xenopus laevis Neuropilin 1 (NRP1) interaction partners

  1. Neuropilin-1 and its co-receptor plexinA1 (show PLXNA1 Proteins) are necessary to bias the extension of the dendrites of retinal ganglion cells to the apical side of the cell, and ectopically expressed class III semaphorins (Sema3s) disrupt this process.

Pig (Porcine) Neuropilin 1 (NRP1) interaction partners

  1. binding of Neuropilin-1 to VEGFR-2 (show KDR Proteins) requires the PDZ-binding domain of neuropilin-1

  2. Neuropilin-1 is essential for enhanced VEGF(165)-mediated vasodilatation in collateral-dependent coronary arterioles of exercise-trained pigs.

Neuropilin 1 (NRP1) Protein Profile

Protein Summary

This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors\; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.

Gene names and symbols associated with Neuropilin 1 Proteins (NRP1)

  • neuropilin 1 (NRP1)
  • neuropilin 1 (nrp1)
  • neuropilin 1 (Nrp1)
  • BDCA4 protein
  • C530029I03 protein
  • CD304 protein
  • neuropilin protein
  • NP-1 protein
  • NP1 protein
  • NPN-1 protein
  • Npn1 protein
  • Nrp protein
  • nrp-1 protein
  • NRP1 protein
  • VEGF165R protein

Protein level used designations for Neuropilin 1 Proteins (NRP1)

neuropilin 1 , neuropilin-1 , A5 antigen , transmembrane receptor , vascular endothelial cell growth factor 165 receptor , A5 protein , Neuropilin-1 precursor (A5 protein) , A5-protein

450397 Pan troglodytes
539369 Bos taurus
100101701 Xenopus (Silurana) tropicalis
100171901 Pongo abelii
8829 Homo sapiens
18186 Mus musculus
246331 Rattus norvegicus
395560 Gallus gallus
477955 Canis lupus familiaris
397804 Xenopus laevis
100286859 Sus scrofa
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