Neuropilin 1 Protein (NRP1) (AA 22-644) (His tag)
Quick Overview for Neuropilin 1 Protein (NRP1) (AA 22-644) (His tag) (ABIN2181552)
Target
See all Neuropilin 1 (NRP1) ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Protein Characteristics
- AA 22-644
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Purification tag / Conjugate
- This Neuropilin 1 protein is labelled with His tag.
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Sequence
- AA 22-644
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Characteristics
- This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 70.7 kDa. The protein migrates as 85-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
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Sterility
- 0.22 μm filtered
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Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
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Neuropilin 1 (NRP1) (AA 22-644) (Active) protein (His tag)
NRP1 Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Neuropilin 1 (NRP1) (AA 22-644) (Active) protein (Fc Tag)NRP1 Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Neuropilin 1 (NRP1) (AA 23-644) protein (GST tag)NRP1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Neuropilin 1 (NRP1) (AA 22-131) protein (GST tag)NRP1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Neuropilin 1 (NRP1) (AA 22-856) protein (His tag)NRP1 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
Neuropilin 1 (NRP1) (AA 22-855) protein (His tag)NRP1 Origin: Rat Host: Baculovirus infected Insect Cells Recombinant > 90 % SDS
Neuropilin 1 (NRP1) (AA 22-856) protein (His tag)NRP1 Origin: Mouse Host: Baculovirus infected Insect Cells Recombinant > 90 % SDS
Neuropilin 1 (NRP1) (AA 22-856) (Active) protein (Fc Tag)NRP1 Origin: Mouse Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Neuropilin 1 (NRP1) (AA 22-644) (Active) protein (His tag,AVI tag,Biotin)NRP1 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- PBS, pH 7.4
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Handling Advice
- Please avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
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- Neuropilin 1 (NRP1)
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Alternative Name
- Neuropilin-1
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Background
- Neuropilin-1 (NRP1) is also known as Vascular endothelial cell growth factor 165 receptor (VEGF165R), CD antigen CD304, which belongs to the neuropilin family. The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells.
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Molecular Weight
- 70.8 kDa
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Pathways
- Regulation of Cell Size, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling, VEGFR1 Specific Signals
Target
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