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Neuropilin 1 Protein (NRP1) (AA 22-644) (Fc Tag)

NRP1 Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Pubmed (1 reference)
Catalog No. ABIN2181550
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  • Target See all Neuropilin 1 (NRP1) Proteins
    Neuropilin 1 (NRP1)
    Protein Type
    Recombinant
    Biological Activity
    Active
    Protein Characteristics
    AA 22-644
    Origin
    • 13
    • 8
    • 5
    • 1
    Human
    Source
    • 11
    • 8
    • 4
    • 3
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This Neuropilin 1 protein is labelled with Fc Tag.
    Sequence
    AA 22-644
    Characteristics
    This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 96.5 kDa. The protein migrates as 120-125 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    Purity
    >90 % as determined by SDS-PAGE.
    Sterility
    0.22 μm filtered
    Endotoxin Level
    Less than 1.0 EU per μg by the LAL method.
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    Tris with Glycine, Arginine and NaCl,  pH 7.5
    Handling Advice
    Please avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
  • Kerros, Tripathi, Zha, Mehrens, Sergeeva, Philips, Qiao, Peters, Katayama, Sukhumalchandra, Ruisaard, Perakis, St John, Lu, Mittendorf, Clise-Dwyer, Herrmann, Alatrash, Toniatti, Hanash, Ma, Molldrem: "Neuropilin-1 mediates neutrophil elastase uptake and cross-presentation in breast cancer cells." in: The Journal of biological chemistry, Vol. 292, Issue 24, pp. 10295-10305, (2017) (PubMed).

  • Target
    Neuropilin 1 (NRP1)
    Alternative Name
    Neuropilin-1 (NRP1 Products)
    Synonyms
    NRP1, cd304, neuropilin, np-1, npn-1, nrp, nrp-1, vegf165r, BDCA4, CD304, NP1, NRP, VEGF165R, C530029I03, NP-1, NPN-1, Npn1, Nrp, neuropilin 1, neuropilin 1 L homeolog, NRP1, nrp1, Nrp1, nrp1.L
    Background
    Neuropilin-1 (NRP1) is also known as Vascular endothelial cell growth factor 165 receptor (VEGF165R), CD antigen CD304, which belongs to the neuropilin family. The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells.
    Molecular Weight
    96.5 kDa
    Pathways
    Regulation of Cell Size, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling, VEGFR1 Specific Signals
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