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OLIG2 encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. Additionally we are shipping OLIG2 Antibodies (119) and OLIG2 Proteins (6) and many more products for this protein.
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Data show that oligodendrocyte transcription factor 2 (OLIG2) is epigenetically regulated via DNA methylation (show HELLS ELISA Kits) and expressed in a subset of AML (show RUNX1 ELISA Kits) patients.
Ectopic expression of phosphomimetic Olig2 is sufficient to block TGF-beta2 (show TGFB2 ELISA Kits)-mediated invasion.
phosphorylation of the motif itself serves as a template to prime phosphorylation of additional serines and creates a highly charged "acid blob" in the amino terminus of Olig2.
Olig2 was expressed in cord blood eosinophils on d 24, when cord blood eosinophils are considered fully differentiated, but no earlier. It was also expressed in human peripheral-blood eosinophils but not neutrophils, monocytes, lymphocytes, or cord blood mast cells. Many genes, including eosinophil surface molecules, were up-regulated along with OLIG2. OLIG2 shRNA or siRNA downregulated SIGLEC-8 (show SIGLEC8 ELISA Kits) mRNA and protein.
Data indicate that transcription factors Sox10 (show SOX10 ELISA Kits) and Olig2 play key roles in oligodendrocytes (OLs) specification.
Olig2 expressions were successfully detected in 12 (15.58%) of 77 SVZ type II Glioblastomas (GBs (show GNB5 ELISA Kits)) and 16 (21.3%) of 75 SVZ type III GBs (show GNB5 ELISA Kits).
Olig2 was positive in 5 out of 44 ependymomas (11%) and 50 out of 54 (93%) non-ependymal tumors
The present study is the first to verify the associations of SNPs rs762178, rs1059004, and rs9653711 of the OLIG2 gene with OCD in a Chinese Han population. Thus, OLIG2 might serve as a potential target for OCD treatment
The results demonstrate that the expression of Olig2 in dental pulp stem cells reduces the expression of stem cell markers and induces the development of oligodendrocyte progenitors.
High Olig2 expression is associated with oligodendrogliomas.
these data raise the possibility that cells expressing olig2 are intermediate targets that help guide facial motor neuron migration.
Study detected at least five different classes of olig2-positive cells in the telencephalon of the adult zebrafish.
By cooperating with Shh (show SHH ELISA Kits), FGF-receptor (show FGFR2 ELISA Kits) signalling controls the expression of olig2, a patterning gene essential for the specification of somatic motoneurons and oligodendrocytes.
Loss of olig2 function prevents primary motor neuron and oligodendrocyte development, whereas olig2 overexpression promotes formation of excess primary motor neurons and oligodendrocytes.
Olig2 is required for repression of iro3 (show IRX3 ELISA Kits) expression in the progenitor domain of ventral spinal cord
data indicate that Hedgehog (show SHH ELISA Kits) & Wnt (show WNT2 ELISA Kits) work in opposition across the dorsoventral axis of the cerebellum to regulate formation of olig2(+) neurons; we propose that Hedgehog (show SHH ELISA Kits) limits the range of Wnt (show WNT2 ELISA Kits) signaling, which is necessary for olig2(+) neuron development
commitment of basal diencephalic DA neurons is regulated by the combined action of the neural protein Olig2 and its downstream neuronal specific effector Sim1
OLIG2 modulates growth factor signaling in two distinct populations of glioma stem cells, characterized by expression of either the epidermal growth factor receptor (EGFR (show EGFR ELISA Kits)) or platelet-derived growth factor receptor alpha (show PDGFRA ELISA Kits).
the dynamic interplay between HMGNs and H1 in chromatin epigenetically regulates the expression of OLIG1 (show OLIG1 ELISA Kits)&2, thereby affecting oligodendrocyte development and myelination, and mouse behavior.
Olig2 was significantly upregulated and transcriptionally targeted the Gpr17 (show GPR17 ELISA Kits) locus
Brg1 (show SMARCA4 ELISA Kits) represses Olig2 expression and the specification of oligodendrocyte progenitors, but is required for OPC differentiation and oligodendrocyte maturation
Data show that oligodendrocyte transcription factor 2 (Olig2) deletion causes platelet-derived growth factor receptor (PDGFR (show PDGFRB ELISA Kits)) downregulation and reciprocal epidermal growth factor receptor (EGFR (show EGFR ELISA Kits)) upregulation.
This study suggests that Olig2 misexpression in neural stem cells elicits neurogenesis defects and neuronal cell death, which may contribute to developmental disorders including Down syndrome
OLIG2 is a multifunctional regulator of neural stem cell self-renewal
Olig2 expression is localized to the cochleovestibular ganglia from E12.5 through E14.5
Olig2 overexpression accelerates the differentiation of mouse embryonic stem cells into oligodendrocyte progenitor cells in vitro.
This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14\;21)(q11.2\;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome.
oligodendrocyte transcription factor 4
, oligodendrocyte transcription factor 3
, oligodendrocyte lineage transcription factor 2
, basic domain, helix-loop-helix protein, class B, 1
, class B basic helix-loop-helix protein 1
, class E basic helix-loop-helix protein 19
, human protein kinase C-binding protein RACK17
, oligodendrocyte transcription factor 2
, oligodendrocyte-specific bHLH transcription factor 2
, protein kinase C-binding protein 2
, bHLH transcription factor Olig2