SH3-Domain GRB2-Like 1 Proteins (SH3GL1)

SH3GL1 encodes a member of the endophilin family of Src homology 3 domain-containing proteins. Additionally we are shipping SH3GL1 Antibodies (125) and SH3GL1 Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SH3GL1 6455 Q99961
SH3GL1 20405 Q62419
SH3GL1 81922 O35964
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Top SH3GL1 Proteins at

Showing 7 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
Yeast Chicken His tag   1 mg Log in to see 60 to 71 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days

SH3GL1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

More Proteins for SH3-Domain GRB2-Like 1 (SH3GL1) Interaction Partners

Human SH3-Domain GRB2-Like 1 (SH3GL1) interaction partners

  1. inhibition of SH3GL1 reverses multidrug resistance through declining P-glycoprotein expression via the EGFR (show EGFR Proteins)/ERK (show EPHB2 Proteins)/AP-1 (show FOSB Proteins) pathway.

  2. results establish a novel function of endoA2 in clathrin-independent endocytosis

  3. these data suggest that EEN may play a pivotal role in excessive cell proliferation and insufficient cell apoptosis of bone marrow plasma cells in multiple myeloma.

  4. MIR218 functions as a tumor suppressor by regulating SH3GL1 expression in medulloblastoma cancer cells.

  5. SH3GL1 may be involved in the oncogenic process of gliomas and effectively elicit an autologous antibody response in low-grade gliomas.

  6. Two endophilin A2 mutants, E264A and E264R, have different effects on how endophilin interacts with other proteins, such as dynamin (show DNM1 Proteins) or beta1-adrenergic receptors.

  7. Idiopathic scoliosis is a multifactorial genetic disease and SH3GL1 may be one of the pathogenic genes for this disease.

  8. SH3GL1 is possibly one of the disease associated genes of adolescent idiopathic scoliosis.

  9. new mechanism for MLL (show MLL Proteins)-EEN-mediated leukemogenesis in which MLL (show MLL Proteins)-EEN interferes with the Ras-suppressing activities of EBP (show EBP Proteins) through direct interaction.

  10. EEN part plays an essential role in leukemogenesis caused by MLL (show MLL Proteins)-EEN.

Mouse (Murine) SH3-Domain GRB2-Like 1 (SH3GL1) interaction partners

  1. This study provides a new mechanism by which endophilin A2 regulates ClC-3 (show CLCN3 Proteins) channel activity, and sheds light on how ClC-3 (show CLCN3 Proteins) is transported to cell membranes to play its critical role as a chloride channel (show CLCA1 Proteins) in VSMCs function

  2. Mutation in the FAK (show PTK2 Proteins) gene disrupted the function of FAK (show PTK2 Proteins) scaffolding to mediate endophilin A2 phosphorylation at Tyr (show TYR Proteins)-315 by Src (show SRC Proteins), leading to the decreased surface expression of MT1-MMP (show MMP14 Proteins).

  3. these results demonstrate that MNSFbeta/endophilin II inhibits the signal pathway upstream of IKK activation, but not downstream of TLR2 signaling.

  4. Further analysis based on antibody staining of central and peripheral nerves revealed beta-adducin (show ADD2 Proteins), septin 2 (show SEPT2 Proteins), and sh3p8 as putative paranodal proteins.

  5. Mll (show MLL Proteins)(Een/+) chimeric mice developed leukaemia displaying enlarged livers, spleens, thymuses and lymph nodes owing to infiltration of Mll (show MLL Proteins)(Een/+)-expressing leukemic cells

  6. post-translational modification of endophilin II by MNSFbeta (show FAU Proteins) might be implicated in phagocytosis by macrophages.

SH3GL1 Protein Profile

Protein Summary

This gene encodes a member of the endophilin family of Src homology 3 domain-containing proteins. The encoded protein is involved in endocytosis and may also play a role in the cell cycle. Overexpression of this gene may play a role in leukemogenesis, and the encoded protein has been implicated in acute myeloid leukemia as a fusion partner of the myeloid-lymphoid leukemia protein. Pseudogenes of this gene are located on the long arm of chromosomes 11 and 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with SH3GL1

  • SH3-domain GRB2-like 1b (sh3gl1b)
  • SH3-domain GRB2-like 1 (sh3gl1)
  • SH3-domain GRB2-like 1 (SH3GL1)
  • SH3-domain GRB2-like 1 (Sh3gl1)
  • C77078 protein
  • cb831 protein
  • CNSA1 protein
  • EEN protein
  • MGC78966 protein
  • MGC130739 protein
  • Sh3d2b protein
  • sh3gl1 protein
  • SH3P8 protein

Protein level used designations for SH3GL1

SH3-domain GRB2-like 1 , eena , endophilin-A2 , EEN fusion partner of MLL , SH3 domain protein 2B , SH3 domain-containing GRB2-like protein 1 , SH3-containing Grb-2-like 1 protein , endophilin-2 , extra 11-19 leukemia fusion , extra eleven-nineteen leukemia fusion gene protein , endophilin II , SH3 domain-containing GRB2-like protein 2

378838 Danio rerio
432228 Xenopus laevis
619364 Xenopus (Silurana) tropicalis
6455 Homo sapiens
20405 Mus musculus
81922 Rattus norvegicus
485039 Canis lupus familiaris
512719 Bos taurus
395202 Gallus gallus
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