Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
SIAH2 encodes a protein that is a member of the seven in absentia homolog (SIAH) family. Additionally we are shipping SIAH2 Proteins (7) and SIAH2 Kits (3) and many more products for this protein.
Showing 10 out of 60 products:
Fruit Fly (Drosophila melanogaster) Monoclonal SIAH2 Primary Antibody for ICC, FACS - ABIN259955
Chan, Möller, Liu, Sceneay, Wong, Waddell, Huang, Dobrovic, Millar, OToole, McNeil, Sutherland, Bowtell, Fox: The expression of the ubiquitin ligase SIAH2 (seven in absentia homolog 2) is mediated through gene copy number in breast cancer and is associated with a basal-like phenotype and p53 expression. in Breast cancer research : BCR 2011
Show all 13 Pubmed References
Human Polyclonal SIAH2 Primary Antibody for IHC (p), IHC - ABIN446903
Kilroy, Kirk-Ballard, Carter, Floyd: The ubiquitin ligase Siah2 regulates PPARγ activity in adipocytes. in Endocrinology 2012
Show all 2 Pubmed References
High Siah2 expression is associated with increased adipogenesis.
Siah2(-/-) endothelial cells have an intact hypoxic signalling pathway, including Hif-1alpha (show HIF1A Antibodies) stabilisation and gene expression, the first report of a tissue or cell lineage in which the loss of Siah2 does not seem to impact hypoxic response signaling.
Siah2 links adipocyte hypertrophy with adipocyte dysfunction and recruitment of proinflammatory immune cells to adipose tissue.
A catalysis-independent role for AKR1C3 (show AKR1C3 Antibodies) on AR activity via Siah2 has been identified.
Combination of netrin-1 and SIAH RNAi may prove to be a substantially effective therapy for myocardial infarction.
Siah1/2 constitutes an obligatory fine-tuning mechanism that predisposes cells to death under severe ER stress conditions
our studies demonstrate the role of Siah2 in regulation of tight junction integrity and cell polarity under hypoxia, through its regulation of ASPP2 (show TP53BP2 Antibodies) stability.
Blood vessel normalization in Siah2(-/-) tumors resulted in an increased response to chemotherapy and prolonged survival
modulation of PPARgamma (show PPARG Antibodies) protein levels by the ubiquitin ligase Siah2 is essential in determining the physiological effects of PPARgamma (show PPARG Antibodies) activation in adipocytes
Siah2 is a key regulator of hypoxia-induced mitochondrial fission and plays role in ischemic injury
The E3 ubiquitin ligase (show MUL1 Antibodies) activity of Siah2 is required for Nodal signaling during zebrafish embryonic development.
Study identified SIAH1 (show SIAH1 Antibodies)/2 (SIAH (show SIAH1 Antibodies)) as the E3 ligase mediating Wnt (show WNT2 Antibodies)-induced Axin (show AXIN1 Antibodies) degradation. SIAH (show SIAH1 Antibodies) proteins promote the ubiquitination and proteasomal degradation of Axin (show AXIN1 Antibodies) through interacting with a VxP motif in the GSK3 (show GSK3b Antibodies)-binding domain of Axin (show AXIN1 Antibodies), and this function of SIAH (show SIAH1 Antibodies) is counteracted by GSK3 (show GSK3b Antibodies) binding to Axin (show AXIN1 Antibodies).
SIAH2 regulates CHK2 (show CHEK2 Antibodies) basal turnover, with important consequences on cell-cycle control and on the ability of hypoxia to alter the DNA damage-response pathway in cancer cells.
study revealed an interesting mutual regulation between Plk3 (show PLK3 Antibodies) and SIAH2 and uncovered a regulatory network that functions to fine-tune the cellular hypoxic response.
ETS2 (show ETS2 Antibodies) and Twist1 (show TWIST1 Antibodies) promote invasiveness of Helicobacter pylori-infected gastric cancer cells by inducing Siah2
Manipulation of SIAH2 expression led to a 'cross-talk' of the ERK (show EPHB2 Antibodies) and PI3K (show PIK3CA Antibodies) pathway.
Siah-2 expression was observed in 29.3% of oral squamous cell carcinoma. Siah-2 was located in the cytoplasm and cell membranes.
SIAH2 is associated with a tumor promoting role in breast cancer.
Overexpression of Siah2 Is Associated With Epithelial Ovarian Carcinoma
Our results suggest that SIAH2 regulates multi processes in T-cell acute lymphoblastic leukemia
The expression of SIAH2 is increased in human lung cancer.
Over-expression of xSiah2 decreased PHD45 but not PHD28 and caused the small-eye phenotype of Xenopus
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia.
seven in absentia homolog 2
, seven in absentia-like protein
, E3 ubiquitin-protein ligase SIAH2
, E3 ubiquitin-protein ligase Siah2
, seven in absentia 2-like
, seven in absentia homolog 2-like
, ubiquitin ligase siah2
, seven in absentia 2
, E3 ubiquitin-protein ligase siah2