anti-Siah E3 Ubiquitin Protein Ligase 2 (SIAH2) Antibodies

SIAH2 encodes a protein that is a member of the seven in absentia homolog (SIAH) family. Additionally we are shipping SIAH2 Proteins (7) and SIAH2 Kits (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SIAH2 20439 Q06986
SIAH2 6478 O43255
SIAH2 140593 Q8R4T2
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Top anti-SIAH2 Antibodies at antibodies-online.com

Showing 10 out of 60 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB Host: Rabbit Target Name: SIAH2 Sample Type: 721_B Antibody Dilution: 1.0ug/ml  SIAH2 is supported by BioGPS gene expression data to be expressed in 721_B WB Suggested Anti-SIAH2 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: Human Muscle 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-SIAH2 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:1562500<br><b>Positive Control: </b>Hela cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Fruit Fly Mouse Un-conjugated ICC, FACS, IHC (fro), IF, IHC (p), IHC, WB Immunofluorescent staining of SIAH in ovarian carcinoma (OVCR3)cells using ABIN259955. 0.5 mL Log in to see 7 to 9 Days
$408.19
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from COLO cells, using SIAH2 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC (p), IHC, WB 0.1 mL Log in to see 7 to 9 Days
$447.56
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB SIAH2 Antibody (Center) (ABIN652059) western blot analysis in T47D cell line lysates (35 µg/lane). This demonstrates the SIAH2 antibody detected the SIAH2 protein (arrow). SIAH2 Antibody (Center) (ABIN652059) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$324.50
Details
Bat Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated IF (p), IHC (p) Lane 1: mouse spleen lysates Lane 2: mouse brain lysates probed with Anti SIAH2 Polyclonal Antibody, Unconjugated (ABIN701875) at 1:200 in 4 °C. Followed by conjugation to secondary antibody at 1:3000 90min in 37 °C. Predicted band 36kD. Observed band size: 36kD 100 μL Log in to see 3 to 7 Days
$295.90
Details
Human Rabbit Un-conjugated ELISA, IHC, WB 100 μL Log in to see 16 Days
$175.80
Details
Human Rabbit Un-conjugated IHC (p), WB <b>Immunohistochemistry</b> (IHC) analyzes of Siah-2 antibody in paraffin-embedded human heart tissue. <b>Western blot</b> (WB) analysis of Siah-2 antibody in extracts from COLO cells. 0.1 mg Log in to see 6 to 8 Days
$390.50
Details

SIAH2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-SIAH2 Antibodies

  1. Fruit Fly (Drosophila melanogaster) Monoclonal SIAH2 Primary Antibody for ICC, FACS - ABIN259955 : Chan, Möller, Liu, Sceneay, Wong, Waddell, Huang, Dobrovic, Millar, OToole, McNeil, Sutherland, Bowtell, Fox: The expression of the ubiquitin ligase SIAH2 (seven in absentia homolog 2) is mediated through gene copy number in breast cancer and is associated with a basal-like phenotype and p53 expression. in Breast cancer research : BCR 2011 (PubMed)
    Show all 13 Pubmed References

  2. Human Polyclonal SIAH2 Primary Antibody for IHC (p), IHC - ABIN446903 : Kilroy, Kirk-Ballard, Carter, Floyd: The ubiquitin ligase Siah2 regulates PPARγ activity in adipocytes. in Endocrinology 2012 (PubMed)
    Show all 2 Pubmed References

More Antibodies against SIAH2 Interaction Partners

Mouse (Murine) Siah E3 Ubiquitin Protein Ligase 2 (SIAH2) interaction partners

  1. High Siah2 expression is associated with increased adipogenesis.

  2. Siah2(-/-) endothelial cells have an intact hypoxic signalling pathway, including Hif-1alpha (show HIF1A Antibodies) stabilisation and gene expression, the first report of a tissue or cell lineage in which the loss of Siah2 does not seem to impact hypoxic response signaling.

  3. Siah2 links adipocyte hypertrophy with adipocyte dysfunction and recruitment of proinflammatory immune cells to adipose tissue.

  4. A catalysis-independent role for AKR1C3 (show AKR1C3 Antibodies) on AR activity via Siah2 has been identified.

  5. Combination of netrin-1 and SIAH RNAi may prove to be a substantially effective therapy for myocardial infarction.

  6. Siah1/2 constitutes an obligatory fine-tuning mechanism that predisposes cells to death under severe ER stress conditions

  7. our studies demonstrate the role of Siah2 in regulation of tight junction integrity and cell polarity under hypoxia, through its regulation of ASPP2 (show TP53BP2 Antibodies) stability.

  8. Blood vessel normalization in Siah2(-/-) tumors resulted in an increased response to chemotherapy and prolonged survival

  9. modulation of PPARgamma (show PPARG Antibodies) protein levels by the ubiquitin ligase Siah2 is essential in determining the physiological effects of PPARgamma (show PPARG Antibodies) activation in adipocytes

  10. Siah2 is a key regulator of hypoxia-induced mitochondrial fission and plays role in ischemic injury

Zebrafish Siah E3 Ubiquitin Protein Ligase 2 (SIAH2) interaction partners

  1. The E3 ubiquitin ligase (show MUL1 Antibodies) activity of Siah2 is required for Nodal signaling during zebrafish embryonic development.

Human Siah E3 Ubiquitin Protein Ligase 2 (SIAH2) interaction partners

  1. Study identified SIAH1 (show SIAH1 Antibodies)/2 (SIAH (show SIAH1 Antibodies)) as the E3 ligase mediating Wnt (show WNT2 Antibodies)-induced Axin (show AXIN1 Antibodies) degradation. SIAH (show SIAH1 Antibodies) proteins promote the ubiquitination and proteasomal degradation of Axin (show AXIN1 Antibodies) through interacting with a VxP motif in the GSK3 (show GSK3b Antibodies)-binding domain of Axin (show AXIN1 Antibodies), and this function of SIAH (show SIAH1 Antibodies) is counteracted by GSK3 (show GSK3b Antibodies) binding to Axin (show AXIN1 Antibodies).

  2. SIAH2 regulates CHK2 (show CHEK2 Antibodies) basal turnover, with important consequences on cell-cycle control and on the ability of hypoxia to alter the DNA damage-response pathway in cancer cells.

  3. study revealed an interesting mutual regulation between Plk3 (show PLK3 Antibodies) and SIAH2 and uncovered a regulatory network that functions to fine-tune the cellular hypoxic response.

  4. ETS2 (show ETS2 Antibodies) and Twist1 (show TWIST1 Antibodies) promote invasiveness of Helicobacter pylori-infected gastric cancer cells by inducing Siah2

  5. Manipulation of SIAH2 expression led to a 'cross-talk' of the ERK (show EPHB2 Antibodies) and PI3K (show PIK3CA Antibodies) pathway.

  6. Siah-2 expression was observed in 29.3% of oral squamous cell carcinoma. Siah-2 was located in the cytoplasm and cell membranes.

  7. SIAH2 is associated with a tumor promoting role in breast cancer.

  8. Overexpression of Siah2 Is Associated With Epithelial Ovarian Carcinoma

  9. Our results suggest that SIAH2 regulates multi processes in T-cell acute lymphoblastic leukemia

  10. The expression of SIAH2 is increased in human lung cancer.

Xenopus laevis Siah E3 Ubiquitin Protein Ligase 2 (SIAH2) interaction partners

  1. Over-expression of xSiah2 decreased PHD45 but not PHD28 and caused the small-eye phenotype of Xenopus

SIAH2 Antigen Profile

Protein Summary

This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia.

Gene names and symbols associated with SIAH2

  • siah E3 ubiquitin protein ligase 2 (SIAH2) antibody
  • seven in absentia 2 (Siah2) antibody
  • seven in absentia homolog 2 (Drosophila) (SIAH2) antibody
  • seven in absentia homolog 2 (Drosophila)-like (siah2l) antibody
  • siah E3 ubiquitin protein ligase 2 (Siah2) antibody
  • siah E3 ubiquitin protein ligase 2 (siah2) antibody
  • AA415433 antibody
  • hSiah2 antibody
  • siah2-A antibody
  • siaz antibody
  • Sinh2 antibody
  • Xsiah-2 antibody
  • xsiah2 antibody
  • zgc:66284 antibody

Protein level used designations for SIAH2

seven in absentia homolog 2 , seven in absentia-like protein , E3 ubiquitin-protein ligase SIAH2 , mSiah2 , siah-2 , E3 ubiquitin-protein ligase Siah2 , seven in absentia 2-like , seven in absentia homolog 2-like , ubiquitin ligase siah2 , seven in absentia 2 , E3 ubiquitin-protein ligase siah2

GENE ID SPECIES
100034000 Equus caballus
20439 Mus musculus
429164 Gallus gallus
378728 Danio rerio
6478 Homo sapiens
140593 Rattus norvegicus
373622 Xenopus laevis
785659 Bos taurus
100683719 Canis lupus familiaris
100622531 Sus scrofa
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