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anti-Siah E3 Ubiquitin Protein Ligase 2 (SIAH2) Antibodies

SIAH2 encodes a protein that is a member of the seven in absentia homolog (SIAH) family. Additionally we are shipping SIAH2 Proteins (7) and SIAH2 Kits (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SIAH2 20439 Q06986
SIAH2 6478 O43255
SIAH2 140593 Q8R4T2
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Top anti-SIAH2 Antibodies at

Showing 10 out of 54 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated WB WB Suggested Anti-SIAH2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: Hela cell lysate Host: Rabbit  Target Name: SIAH2  Sample Tissue: HelaLane A:  Primary Antibody Lane B:  Primary Antibody + Blocking Peptide Primary Antibody Concentration: 1 µg/mL Peptide Concentration: 5 µg/mL Lysate Quantity: 41 µg/lane/laneGel Concentration:.12 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from COLO cells, using SIAH2 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
Fruit Fly Mouse Un-conjugated ICC, FACS, IHC (fro), IF, IHC (p), IHC, WB Immunofluorescent staining of SIAH in ovarian carcinoma (OVCR3)cells using ABIN259955. 0.5 mL Log in to see 7 to 9 Days
Human Rabbit Un-conjugated IHC (p), IHC, WB 0.1 mL Log in to see 7 to 9 Days
Human Rabbit Un-conjugated FACS, IHC (p), WB SIAH2 Antibody (Center) (ABIN652059) western blot analysis in T47D cell line lysates (35 µg/lane). This demonstrates the SIAH2 antibody detected the SIAH2 protein (arrow). SIAH2 Antibody (Center) (ABIN652059) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
Human Rabbit Un-conjugated ELISA, IHC, WB 100 μL Log in to see 14 Days
Human Rabbit Un-conjugated IHC (p), WB Immunohistochemistry (IHC) analyzes of Siah-2 antibody in paraffin-embedded human heart tissue. Western blot (WB) analysis of Siah-2 antibody in extracts from COLO cells. 0.1 mg Log in to see 6 to 8 Days
Human Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of SIAH2 staining in MCF7 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a hidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of SIAH2 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 9 Days
Bat Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days

SIAH2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) , , ,

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Top referenced anti-SIAH2 Antibodies

  1. Fruit Fly (Drosophila melanogaster) Monoclonal SIAH2 Primary Antibody for ICC, FACS - ABIN259955 : Chan, Möller, Liu, Sceneay, Wong, Waddell, Huang, Dobrovic, Millar, OToole, McNeil, Sutherland, Bowtell, Fox: The expression of the ubiquitin ligase SIAH2 (seven in absentia homolog 2) is mediated through gene copy number in breast cancer and is associated with a basal-like phenotype and p53 expression. in Breast cancer research : BCR 2011 (PubMed)
    Show all 13 references for ABIN259955

  2. Human Polyclonal SIAH2 Primary Antibody for IHC (p), IHC - ABIN446903 : Kilroy, Kirk-Ballard, Carter, Floyd: The ubiquitin ligase Siah2 regulates PPARγ activity in adipocytes. in Endocrinology 2012 (PubMed)
    Show all 2 references for ABIN446903

  3. Human Polyclonal SIAH2 Primary Antibody for ELISA, WB - ABIN1535499 : Hu, Chung, Glover, Valentine, Look, Fearon: Characterization of human homologs of the Drosophila seven in absentia (sina) gene. in Genomics 1998 (PubMed)

  4. Human Polyclonal SIAH2 Primary Antibody for WB - ABIN2787537 : Rott, Szargel, Haskin, Shani, Shainskaya, Manov, Liani, Avraham, Engelender: Monoubiquitylation of alpha-synuclein by seven in absentia homolog (SIAH) promotes its aggregation in dopaminergic cells. in The Journal of biological chemistry 2008 (PubMed)

More Antibodies against SIAH2 Interaction Partners

Mouse (Murine) Siah E3 Ubiquitin Protein Ligase 2 (SIAH2) interaction partners

  1. Siah2(-/-) endothelial cells have an intact hypoxic signalling pathway, including Hif-1alpha (show HIF1A Antibodies) stabilisation and gene expression, the first report of a tissue or cell lineage in which the loss of Siah2 does not seem to impact hypoxic response signaling.

  2. Siah2 links adipocyte hypertrophy with adipocyte dysfunction and recruitment of proinflammatory immune cells to adipose tissue.

  3. A catalysis-independent role for AKR1C3 (show AKR1C3 Antibodies) on AR activity via Siah2 has been identified.

  4. Combination of netrin-1 and SIAH RNAi may prove to be a substantially effective therapy for myocardial infarction.

  5. Siah1/2 constitutes an obligatory fine-tuning mechanism that predisposes cells to death under severe ER stress conditions

  6. our studies demonstrate the role of Siah2 in regulation of tight junction integrity and cell polarity under hypoxia, through its regulation of ASPP2 (show TP53BP2 Antibodies) stability.

  7. Blood vessel normalization in Siah2(-/-) tumors resulted in an increased response to chemotherapy and prolonged survival

  8. modulation of PPARgamma (show PPARG Antibodies) protein levels by the ubiquitin ligase Siah2 is essential in determining the physiological effects of PPARgamma (show PPARG Antibodies) activation in adipocytes

  9. Siah2 is a key regulator of hypoxia-induced mitochondrial fission and plays role in ischemic injury

  10. Siah2-dependent concerted activity of HIF and FoxA2 (show FOXA2 Antibodies) regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors.

Zebrafish Siah E3 Ubiquitin Protein Ligase 2 (SIAH2) interaction partners

  1. The E3 ubiquitin ligase (show MUL1 Antibodies) activity of Siah2 is required for Nodal signaling during zebrafish embryonic development.

Human Siah E3 Ubiquitin Protein Ligase 2 (SIAH2) interaction partners

  1. Manipulation of SIAH2 expression led to a 'cross-talk' of the ERK (show EPHB2 Antibodies) and PI3K (show PIK3CA Antibodies) pathway.

  2. Siah-2 expression was observed in 29.3% of oral squamous cell carcinoma. Siah-2 was located in the cytoplasm and cell membranes.

  3. SIAH2 is associated with a tumor promoting role in breast cancer.

  4. Overexpression of Siah2 Is Associated With Epithelial Ovarian Carcinoma

  5. Our results suggest that SIAH2 regulates multi processes in T-cell acute lymphoblastic leukemia

  6. The expression of SIAH2 is increased in human lung cancer.

  7. the E3 ubiquitin ligase (show MUL1 Antibodies) SIAH2 stimulates YAP (show YAP1 Antibodies) by destabilizing LATS2 (show LATS2 Antibodies), a critical component of the Hippo pathway, in response to hypoxia.

  8. The down-regulation of SIAH2 conferred sensitivity to anti-cancer drugs. The results of the study indicated that the miR (show MLXIP Antibodies)-335/SIAH2/HDAC3 (show HDAC3 Antibodies) axis regulates the response to anti-cancer drugs.

  9. Data show that ubiquitin E3 ligase Siah2 depletion delays circadian degradation of nuclear hormone receptor (show NR0B1 Antibodies) RevErbalpha (Nr1d1 (show NR1D1 Antibodies)) and lengthens period length.

  10. Data indicate that ubiquitin ligase Siah (show SIAH1 Antibodies) as a regulator of to Mesenchymal Transition (EMT (show ITK Antibodies)) by controlling the abundance of the key transcription factor Zeb1 (show ZEB1 Antibodies), while Siah (show SIAH1 Antibodies) itself is subject to regulation by EMT (show ITK Antibodies)-inducing factors.

Xenopus laevis Siah E3 Ubiquitin Protein Ligase 2 (SIAH2) interaction partners

  1. Over-expression of xSiah2 decreased PHD45 but not PHD28 and caused the small-eye phenotype of Xenopus

SIAH2 Antigen Profile

Protein Summary

This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia.

Gene names and symbols associated with SIAH2

  • siah E3 ubiquitin protein ligase 2 (SIAH2) antibody
  • seven in absentia 2 (Siah2) antibody
  • seven in absentia homolog 2 (Drosophila) (SIAH2) antibody
  • seven in absentia homolog 2 (Drosophila)-like (siah2l) antibody
  • siah E3 ubiquitin protein ligase 2 (Siah2) antibody
  • siah E3 ubiquitin protein ligase 2 (siah2) antibody
  • AA415433 antibody
  • hSiah2 antibody
  • siah2-A antibody
  • siaz antibody
  • Sinh2 antibody
  • Xsiah-2 antibody
  • xsiah2 antibody
  • zgc:66284 antibody

Protein level used designations for SIAH2

seven in absentia homolog 2 , seven in absentia-like protein , E3 ubiquitin-protein ligase SIAH2 , mSiah2 , siah-2 , E3 ubiquitin-protein ligase Siah2 , seven in absentia 2-like , seven in absentia homolog 2-like , ubiquitin ligase siah2 , seven in absentia 2 , E3 ubiquitin-protein ligase siah2

100034000 Equus caballus
20439 Mus musculus
429164 Gallus gallus
378728 Danio rerio
6478 Homo sapiens
140593 Rattus norvegicus
373622 Xenopus laevis
785659 Bos taurus
100683719 Canis lupus familiaris
100622531 Sus scrofa
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