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SIGLEC7 Antibodies

(Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7))
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).
SIGLEC7 antibody  (AA 377-467) SIGLEC7 antibody  (AA 377-467) SIGLEC7 antibody (AA 377-467) (ABIN7169566)

SIGLEC7 Reactivity: Human ELISA, IF, IHC, WB Host: Rabbit Polyclonal unconjugated

SIGLEC7 antibody  (Internal Region) SIGLEC7 antibody  (Internal Region) SIGLEC7 antibody (Internal Region) (ABIN3187804)

SIGLEC7 Reactivity: Human ELISA, IHC (p), WB Host: Rabbit Polyclonal unconjugated

SIGLEC7 antibody  (Center) SIGLEC7 antibody  (Center) SIGLEC7 antibody (Center) (ABIN2856478)

SIGLEC7 Reactivity: Human ICC, IF, IHC (p), WB Host: Rabbit Polyclonal unconjugated

SIGLEC7 Antibodies by Reactivity

Find SIGLEC7 Antibodies for a variety of species such as anti-Human SIGLEC7, anti-Mouse SIGLEC7, anti-Monkey SIGLEC7. The species listed below are among those available. Click on a link to go to the corresponding products.

SIGLEC7 Antibodies by Application

Find SIGLEC7 Antibodies validated for a specific application such as WB, ELISA, IHC, FACS. Some of the available applications are listed below. Click on a link to go to the corresponding products.

SIGLEC7 Antibodies by Host

Find SIGLEC7 Antibodies with a specific Host. The Host listed below are among those available. Click on a link to go to the corresponding products.

SIGLEC7 Antibodies by Binding Specificity

Find SIGLEC7 Antibodies with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

SIGLEC7 Antibodies by Clonality

Find available monoclonal or polyclonal SIGLEC7 Antibodies. Click on a link to go to the corresponding products.

SIGLEC7 Antibodies by Clone

Find SIGLEC7 Antibodies with a specific Clone. The Clone listed below are among those available. Click on a link to go to the corresponding products.

SIGLEC7 Antibodies by Conjugate

Find SIGLEC7 Antibodies with a specific conjugate such as FITC, Biotin, PE. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular SIGLEC7 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application FACS
Validations
  • (3)
Cat. No. ABIN2749127
Quantity 100 tests
Datasheet Datasheet
Reactivity Human
Application ICC, IHC, WB
Validations
  • (3)
Cat. No. ABIN1175022
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application IHC, ELISA, WB
Validations
  • (3)
Cat. No. ABIN3032556
Quantity 0.4 mL
Datasheet Datasheet
Reactivity Human
Application IHC, ELISA, WB
Validations
  • (3)
Cat. No. ABIN3032557
Quantity 0.4 mL
Datasheet Datasheet
Reactivity Human
Application ICC, IHC, WB
Validations
  • (2)
Cat. No. ABIN1860556
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
  • (1)
Cat. No. ABIN2782808
Quantity 100 μL
Datasheet Datasheet
Reactivity Cow, Dog, Guinea Pig, Horse, Human
Application WB
Validations
  • (1)
  • (1)
Cat. No. ABIN2782809
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (2)
Cat. No. ABIN525812
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application EIA, IHC (p), WB
Validations
  • (2)
Cat. No. ABIN357147
Quantity 0.4 mL
Datasheet Datasheet
Reactivity Human
Application EIA, IHC (p), WB
Validations
  • (2)
Cat. No. ABIN357160
Quantity 0.4 mL
Datasheet Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (1)
Cat. No. ABIN7186223
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN634715
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (1)
Cat. No. ABIN565311
Quantity 50 μL
Datasheet Datasheet
Reactivity Human
Application IHC, WB
Validations
  • (1)
Cat. No. ABIN1983435
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN5587916
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our SIGLEC7 Antibodies

Dharmadhikari, Stolz, Hauke, Morgan, Varki, de Koning, Kelm, Maedler: "Siglec-7 restores β-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes." in: Scientific reports, Vol. 7, pp. 45319, (2017) (PubMed).

Izquierdo-Useros, Lorizate, Puertas, Rodriguez-Plata, Zangger, Erikson, Pino, Erkizia, Glass, Clotet, Keppler, Telenti, Kräusslich, Martinez-Picado: "Siglec-1 is a novel dendritic cell receptor that mediates HIV-1 trans-infection through recognition of viral membrane gangliosides." in: PLoS biology, Vol. 10, Issue 12, pp. e1001448, (2012) (PubMed).

Varchetta, Brunetta, Roberto, Mikulak, Hudspeth, Mondelli, Mavilio: "Engagement of Siglec-7 receptor induces a pro-inflammatory response selectively in monocytes." in: PLoS ONE, Vol. 7, Issue 9, pp. e45821, (2012) (PubMed).

Zou, Chastain, Moir, Ford, Trandem, Martinelli, Cicala, Crocker, Arthos, Sun: "Siglecs facilitate HIV-1 infection of macrophages through adhesion with viral sialic acids." in: PLoS ONE, Vol. 6, Issue 9, pp. e24559, (2011) (PubMed).

Jaroenpool, Rogers, Pattanapanyasat, Villinger, Onlamoon, Crocker, Ansari: "Differences in the constitutive and SIV infection induced expression of Siglecs by hematopoietic cells from non-human primates." in: Cellular immunology, Vol. 250, Issue 1-2, pp. 91-104, (2008) (PubMed).

Avril, Wagner, Willison, Crocker: "Sialic acid-binding immunoglobulin-like lectin 7 mediates selective recognition of sialylated glycans expressed on Campylobacter jejuni lipooligosaccharides." in: Infection and immunity, Vol. 74, Issue 7, pp. 4133-41, (2006) (PubMed).

Alphey, Attrill, Crocker, van Aalten: "High resolution crystal structures of Siglec-7. Insights into ligand specificity in the Siglec family." in: The Journal of biological chemistry, Vol. 278, Issue 5, pp. 3372-7, (2003) (PubMed).

Nicoll, Avril, Lock, Furukawa, Bovin, Crocker: "Ganglioside GD3 expression on target cells can modulate NK cell cytotoxicity via siglec-7-dependent and -independent mechanisms." in: European journal of immunology, Vol. 33, Issue 6, pp. 1642-8, (2003) (PubMed).

Angata, Hingorani, Varki, Varki: "Cloning and characterization of a novel mouse Siglec, mSiglec-F: differential evolution of the mouse and human (CD33) Siglec-3-related gene clusters." in: The Journal of biological chemistry, Vol. 276, Issue 48, pp. 45128-36, (2001) (PubMed).

Crocker, Varki: "Siglecs, sialic acids and innate immunity." in: Trends in immunology, Vol. 22, Issue 6, pp. 337-42, (2001) (PubMed).

Aliases for SIGLEC7 Antibodies

sialic acid-binding Ig-like lectin 7 (LOC468976) Antibodies
sialic acid binding Ig like lectin 7 (SIGLEC7) Antibodies
AIRM1 Antibodies
CD328 Antibodies
CDw328 Antibodies
D-siglec Antibodies
p75 Antibodies
p75/AIRM1 Antibodies
QA79 Antibodies
SIGLEC-7 Antibodies
SIGLEC7 Antibodies
SIGLEC19P Antibodies
SIGLECP2 Antibodies
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