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SIGLEC8 Antibodies

(Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8))
Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM\\\\; MIM 603492) that mediates an association with SLAM-associated protein (SAP\\\\; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]).[supplied by OMIM, May 2010].
SIGLEC8 antibody SIGLEC8 antibody SIGLEC8 antibody (ABIN7192372)

SIGLEC8 Reactivity: Human ELISA, IHC Host: Rabbit Polyclonal unconjugated

SIGLEC8 antibody  (AA 70-336) SIGLEC8 antibody  (AA 70-336) SIGLEC8 antibody (AA 70-336) (ABIN1870885)

SIGLEC8 Reactivity: Human WB, IHC, ICC Host: Rabbit Polyclonal unconjugated

SIGLEC8 antibody  (AA 18-121) SIGLEC8 antibody  (AA 18-121) SIGLEC8 antibody (AA 18-121) (ABIN565353)

SIGLEC8 Reactivity: Human WB, ELISA Host: Mouse Polyclonal unconjugated

SIGLEC8 Antibodies by Grade

Find SIGLEC8 Antibodies with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

SIGLEC8 Antibodies by Reactivity

Find SIGLEC8 Antibodies for a variety of species such as anti-Human SIGLEC8, anti-Mouse SIGLEC8, anti-Rat SIGLEC8. The species listed below are among those available. Click on a link to go to the corresponding products.

SIGLEC8 Antibodies by Application

Find SIGLEC8 Antibodies validated for a specific application such as WB, ELISA, IHC, IHC (p). Some of the available applications are listed below. Click on a link to go to the corresponding products.

SIGLEC8 Antibodies by Host

Find SIGLEC8 Antibodies with a specific Host. The Host listed below are among those available. Click on a link to go to the corresponding products.

SIGLEC8 Antibodies by Binding Specificity

Find SIGLEC8 Antibodies with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

SIGLEC8 Antibodies by Clonality

Find available monoclonal or polyclonal SIGLEC8 Antibodies. Click on a link to go to the corresponding products.

SIGLEC8 Antibodies by Clone

Find SIGLEC8 Antibodies with a specific Clone. The Clone listed below are among those available. Click on a link to go to the corresponding products.

SIGLEC8 Antibodies by Conjugate

Find SIGLEC8 Antibodies with a specific conjugate such as APC, Biotin, PE. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular SIGLEC8 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7192372
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, ICC
Validations
  • (2)
Cat. No. ABIN1870885
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN565353
Quantity 50 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p)
Validations
  • (2)
Cat. No. ABIN5534687
Quantity 400 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IHC (p)
Validations
  • (2)
Cat. No. ABIN5534688
Quantity 400 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IHC
Validations
  • (2)
Cat. No. ABIN2998632
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN7186224
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (1)
Cat. No. ABIN7426355
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN308467
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN6147766
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB
Validations
  • (1)
Cat. No. ABIN7255347
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IP, FACS
Validations
Cat. No. ABIN7013899
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, FACS
Validations
Cat. No. ABIN7193804
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IHC, IHC (p)
Validations
Cat. No. ABIN1840629
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IHC (p)
Validations
Cat. No. ABIN1809369
Quantity 400 μL
Datasheet Datasheet

Latest Publications for our SIGLEC8 Antibodies

Youngblood, Brock, Leung, Falahati, Bochner, Rasmussen, Peterson, Bebbington, Tomasevic: "Siglec-8 antibody reduces eosinophils and mast cells in a transgenic mouse model of eosinophilic gastroenteritis." in: JCI insight, Vol. 4, Issue 19, (2019) (PubMed).

Yokoi, Choi, Hubbard, Lee, Canning, Lee, Ryu, von Gunten, Bickel, Hudson, Macglashan, Bochner: "Inhibition of FcepsilonRI-dependent mediator release and calcium flux from human mast cells by sialic acid-binding immunoglobulin-like lectin 8 engagement." in: The Journal of allergy and clinical immunology, Vol. 121, Issue 2, pp. 499-505.e1, (2008) (PubMed).

von Gunten, Vogel, Schaub, Stadler, Miescher, Crocker, Simon: "Intravenous immunoglobulin preparations contain anti-Siglec-8 autoantibodies." in: The Journal of allergy and clinical immunology, Vol. 119, Issue 4, pp. 1005-11, (2007) (PubMed).

Nutku, Aizawa, Hudson, Bochner: "Ligation of Siglec-8: a selective mechanism for induction of human eosinophil apoptosis." in: Blood, Vol. 101, Issue 12, pp. 5014-20, (2003) (PubMed).

Foussias, Yousef, Diamandis: "Molecular characterization of a Siglec8 variant containing cytoplasmic tyrosine-based motifs, and mapping of the Siglec8 gene." in: Biochemical and biophysical research communications, Vol. 278, Issue 3, pp. 775-81, (2000) (PubMed).

Floyd, Ni, Cornish, Zeng, Liu, Carter, Steel, Crocker: "Siglec-8. A novel eosinophil-specific member of the immunoglobulin superfamily." in: The Journal of biological chemistry, Vol. 275, Issue 2, pp. 861-6, (2000) (PubMed).

Kikly, Bochner, Freeman, Tan, Gallagher, Dalessio, Holmes, Abrahamson, Erickson-Miller, Murdock, Tachimoto, Schleimer, White: "Identification of SAF-2, a novel siglec expressed on eosinophils, mast cells, and basophils." in: The Journal of allergy and clinical immunology, Vol. 105, Issue 6 Pt 1, pp. 1093-100, (2000) (PubMed).

Aliases for SIGLEC8 Antibodies

sialic acid binding Ig like lectin 8 (SIGLEC8) Antibodies
sialic acid-binding Ig-like lectin 8 (LOC506364) Antibodies
SAF2 Antibodies
SIGLEC-8 Antibodies
SIGLEC8 Antibodies
SIGLEC8L Antibodies
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