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SIRT6 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Additionally we are shipping Sirtuin 6 Proteins (24) and Sirtuin 6 Kits (11) and many more products for this protein.
Showing 10 out of 198 products:
Human Polyclonal SIRT6 Primary Antibody for ICC, IF - ABIN250952
Sundaresan, Vasudevan, Zhong, Kim, Samant, Parekh, Pillai, Ravindra, Gupta, Jeevanandam, Cunningham, Deng, Lombard, Mostoslavsky, Gupta: The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun. in Nature medicine 2012
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Cow (Bovine) Polyclonal SIRT6 Primary Antibody for WB - ABIN2779624
Wajapeyee, Malonia, Palakurthy, Green: Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors. in Genes & development 2013
Show all 2 references for ABIN2779624
Human Polyclonal SIRT6 Primary Antibody for IHC (p), WB - ABIN390181
Wu, Liu, Fu, Liu, Zhou: Direct evidence of sirtuin downregulation in the liver of non-alcoholic fatty liver disease patients. in Annals of clinical and laboratory science 2014
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Human Polyclonal SIRT6 Primary Antibody for EIA, WB - ABIN783616
Salminen, Kaarniranta: SIRT1: regulation of longevity via autophagy. in Cellular signalling 2009
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Human Polyclonal SIRT6 Primary Antibody for EIA, IHC (p) - ABIN358735
Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: Complete sequencing and characterization of 21,243 full-length human cDNAs. ... in Nature genetics 2003
Show all 2 references for ABIN358735
Human Polyclonal SIRT6 Primary Antibody for IHC (p), WB - ABIN712483
Thirumurthi, Shen, Xia, LaBaff, Wei, Li, Chang, Chen, Lin, Yu, Hung: MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer. in Science signaling 2014
Human Polyclonal SIRT6 Primary Antibody for WB - ABIN2668661
Rajendran, Kidane, Yu, Dashwood, Bisson, Löhr, Ho, Williams, Dashwood: HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. in Epigenetics 2013
Chicken Polyclonal SIRT6 Primary Antibody for WB - ABIN2779625
Frye: Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. in Biochemical and biophysical research communications 2000
this study shoes that through the antiglycolytic activity of SIRT6, the autophagy is suppressed, which is beneficial to nasal polyp formation
The promoter regions of the SIRT6 gene were genetically analyzed in large cohorts of MI patients (n = 371) and ethnically-matched controls (n = 383). Results: A total of 15 DNA sequence variants (DSVs) were identified, including seven single-nucleotide polymorphisms (SNPs). Two novel heterozygous DSVs, g.4183823G>C and g.4183742G>A, were identified in two MI patients but in none of the controls.
we examined the role and mechanisms of SIRT6 in suppressing postoperative epidural scar formation. We showed that SIRT6 promoted the expression of miR (show MLXIP Antibodies)-21 and then suppressed TGF-beta2 (show TGFB2 Antibodies) expression in a targeted manner.
SIRT6 induced autophagy via attenuation of AKT signaling and treatment with autophagy inhibitor 3-MA or knockdown of autophagy-related protein Atg5 rescued H2O2-induced neuronal injury.
Data indicate that compared to non-neoplastic endometria (NNE (show ENO1 Antibodies)), endometrial cancer (EC) showed SIRT7 (show SIRT7 Antibodies) mRNA overexpression, whereas SIRT1 (show SIRT1 Antibodies), SIRT2 (show SIRT2 Antibodies), SIRT4 (show SIRT4 Antibodies) and SIRT5 (show SIRT5 Antibodies) were underexpressed, and no significant differences were observed for SIRT3 (show SIRT3 Antibodies) and SIRT6.
SIRT6 as an important pancreatic ductal adenocarcinoma tumor suppressor
Tissue micro-array studies confirmed the higher levels of SIRT6 in both prostate tumor tissues and prostate cancer cells than in their normal counterparts. Knockdown of SIRT6 in human prostate cancer cells led to sub-G1 phase arrest of cell cycle, increased apoptosis, elevated DNA damage level and decrease in BCL2 (show BCL2 Antibodies) gene expression.
Results find no significant association between common polymorphisms and haplotypes in the SIRT6 gene and longevity.
Data provided evidence that SIRT6 tagSNPs rs352493 and rs3760908 play significant roles in the severity of coronary artery disease (CAD (show CAD Antibodies)) in Chinese Han subjects, which might be useful predictors of the severity of CAD (show CAD Antibodies).
Results reveal a pathway controlled by ATM, SIRT6, and SNF2H to block HUWE1, which stabilizes H2AX and induces its incorporation into chromatin only when cells are damaged.
results suggest that some polymorphisms in SIRT6 are associated with production traits and may be used as candidates for marker-assisted selection (MAS (show MAS1 Antibodies)) and management in beef cattle breeding programs.
The SIRT6 regulates HSC (show FUT1 Antibodies) homeostasis through the transcriptional repression of Wnt (show WNT2 Antibodies) target genes. Sirt6 deletion promoted HSC (show FUT1 Antibodies) proliferation through aberrant activation of Wnt (show WNT2 Antibodies) signaling.
Sirt6 plays a crucial role in dendritic cell differentiation and function and reduced Sirt6 activity may contribute to immunosenescence.
up-regulates AMP (show TMPRSS5 Antibodies)/ATP and then activates the AMPK (show PRKAA1 Antibodies)-FoxO3alpha axis and further initiates the downstream antioxidant-encoding gene expression, thereby decreasing cellular levels of oxidative stress and mediating cardioprotection in the ischemic heart
SIRT6 is important for glucose-stimulated insulin (show INS Antibodies) secretion from pancreatic beta cells and activation of SIRT6 may be useful to improve insulin (show INS Antibodies) secretion in diabetes
These data strongly suggest that overexpression of Sirt6 can prevent osteoarthritis development by reducing both the inflammatory response and chondrocytes senescence.
Sirt6 depletion causes spindle defects and chromosome misalignment during meiosis of mouse oocyte
In SIRT6-deficient mice there is impaired bone remodeling leading to osteopenia.
SIRT6/NF-kappaB (show NFKB1 Antibodies) signaling axis in ginsenoside Rg1 (show PPP1R3A Antibodies)-delayed hematopoietic stem/progenitor cell senescence.
Data showed the expression levels of SIRT1 (show SIRT1 Antibodies), SIRT3 (show SIRT3 Antibodies), and SIRT6 were decreased in the ovaries of aged mice and mice treated with chemotherapy, but increased in mice treated to caloric restriction suggesting these genes are closely related to ovarian reserve.
Sodium sulfide (show SQRDL Antibodies) protected brain endothelial cells against simulated ischemic injury through SIRT6-dependent mechanisms.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.
sirtuin (silent mating type information regulation 2 homolog) 6
, NAD-dependent deacetylase sirtuin-6
, NAD-dependent protein deacetylase sirtuin-6
, SIR2-like protein 6
, regulatory protein SIR2 homolog 6
, sir2-related protein type 6
, sirtuin type 6