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anti-Sirtuin 6 (SIRT6) Antibodies

SIRT6 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Additionally we are shipping Sirtuin 6 Proteins (24) and Sirtuin 6 Kits (11) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SIRT6 51548 Q8N6T7
SIRT6 50721 P59941
SIRT6 299638  
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Top anti-Sirtuin 6 Antibodies at antibodies-online.com

Showing 10 out of 193 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, IHC (p) 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-SIRT6 Antibody Titration: 1.25ug/mlPositive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated IHC (p), WB Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma Western blot analysis of SIRT6 Antibody (C-term) (ABIN390181) in mouse stomach tissue lysates (35 µg/lane). SIRT6 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Chicken Un-conjugated EIA, WB Western blot analysis of SIRT6 in HeLa cell lysate with SIRT6 antibody at (A) 0.5 and (B) 1 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated WB SIRT6 antibody tested by Western blot. HeLa cells nuclear extract (25 μg) probed with SIRT6 antibody (1:1,000). 100 μL Log in to see 1 to 2 Days
$466.67
Details
Human Mouse Un-conjugated IF, WB Anti-SIRT6 mouse monoclonal antibody (ABIN2455114) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SIRT6 (RC202833). HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SIRT6 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-SIRT6. 100 μL Log in to see 2 to 3 Days
$482.90
Details
Human Rabbit Un-conjugated IHC (p), WB SIRT6 Antibody (C-term) (ABIN657945) western blot analysis in K562 cell line lysates (35 µg/lane). This demonstrates the SIRT6 antibody detected the SIRT6 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Biotin IHC (p), WB   100 μL Log in to see 14 to 21 Days
$379.50
Details
Human Mouse Un-conjugated ELISA Detection limit for recombinant GST tagged SIRT6 is 1 ng/ml as a capture antibody. 100 μg Log in to see 9 Days
$430.00
Details

SIRT6 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Sirtuin 6 Antibodies

  1. Cow (Bovine) Polyclonal SIRT6 Primary Antibody for WB - ABIN2779624 : Wajapeyee, Malonia, Palakurthy, Green: Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors. in Genes & development 2013 (PubMed)
    Show all 2 references for ABIN2779624

  2. Human Monoclonal SIRT6 Primary Antibody for ELISA - ABIN526804 : Grimley, Polyakova, Vamathevan, McKenary, Hayes, Patel, Smith, Bridges, Fosberry, Bhardwaja, Mouzon, Chung, Barrett, Richmond, Modha, Solari: Over expression of wild type or a catalytically dead mutant of Sirtuin 6 does not influence NF?B responses. in PLoS ONE 2012 (PubMed)
    Show all 2 references for ABIN526804

  3. Human Polyclonal SIRT6 Primary Antibody for IHC (p), WB - ABIN390181 : Wu, Liu, Fu, Liu, Zhou: Direct evidence of sirtuin downregulation in the liver of non-alcoholic fatty liver disease patients. in Annals of clinical and laboratory science 2014 (PubMed)
    Show all 2 references for ABIN390181

  4. Human Polyclonal SIRT6 Primary Antibody for EIA, WB - ABIN783616 : Salminen, Kaarniranta: SIRT1: regulation of longevity via autophagy. in Cellular signalling 2009 (PubMed)
    Show all 2 references for ABIN783616

  5. Human Polyclonal SIRT6 Primary Antibody for EIA, IHC (p) - ABIN358735 : Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: Complete sequencing and characterization of 21,243 full-length human cDNAs. ... in Nature genetics 2003 (PubMed)
    Show all 2 references for ABIN358735

  6. Chicken Polyclonal SIRT6 Primary Antibody for WB - ABIN2779625 : Frye: Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. in Biochemical and biophysical research communications 2000 (PubMed)

  7. Human Polyclonal SIRT6 Primary Antibody for WB - ABIN2668661 : Rajendran, Kidane, Yu, Dashwood, Bisson, Löhr, Ho, Williams, Dashwood: HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. in Epigenetics 2013 (PubMed)

  8. Human Polyclonal SIRT6 Primary Antibody for IHC (p), WB - ABIN712483 : Thirumurthi, Shen, Xia, LaBaff, Wei, Li, Chang, Chen, Lin, Yu, Hung: MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer. in Science signaling 2014 (PubMed)

More Antibodies against Sirtuin 6 Interaction Partners

Human Sirtuin 6 (SIRT6) interaction partners

  1. our data suggest that SIRT6 suppresses glioma cell growth via induction of apoptosis, inhibition of oxidative stress and inhibition of the activation of the JAK2 (show JAK2 Antibodies)/STAT3 (show STAT3 Antibodies) signaling pathway.

  2. SIRT6 in a protein complex with both nuclear factor erythroid 2-related factor 2 (NRF2 (show NFE2L2 Antibodies)) and RNA polymerase II.

  3. These data strongly suggest that overexpression of Sirt6 can prevent osteoarthritis development by reducing both the inflammatory response and chondrocytes senescence.

  4. Findings suggest that polymorphisms in SIRT6/UCP1 (show UCP1 Antibodies) genes may be important for increased carotid plaque burden and echodensity

  5. Lamin A (show LMNA Antibodies) promotes SIRT6-dependent DNA-PKcs (DNA-PK catalytic subunit (show PRKDC Antibodies)) recruitment to chromatin.

  6. demonstrate that PKM2 deacetylation is integral to SIRT6-mediated tumor suppression and inhibition of metastasis. Additionally, reduced SIRT6 levels correlate with elevated nuclear acetylated PKM2 levels in increasing grades of hepatocellular carcinoma

  7. SIRT6 mutations identified in human cancers alter either SIRT6 stability, localization, or enzymatic activity. Deacetylase, not demyristoylase, activity is critical for SIRT6 tumor-suppressor.

  8. These findings therefore provide insights into the functional interplay between SIRT6 and DNA repair mechanisms, with implications for both tumorigenesis and the treatment of multiple myeloma.

  9. These results support a hypothesis whereby RUNX2 (show RUNX2 Antibodies)-mediated repression of the SIRT6 tumor suppressor regulates metabolic pathways that promote breast cancer progression

  10. EGF (show EGF Antibodies) stimulates loss of FOXO3 (show FOXO3 Antibodies)/SIRT6, which is blockaded by the inhibition of upstream pathways as well as lipid synthesis, revealing existence of a negative regulatory loop between LDs and FOXO3 (show FOXO3 Antibodies)/SIRT6.

Cow (Bovine) Sirtuin 6 (SIRT6) interaction partners

  1. results suggest that some polymorphisms in SIRT6 are associated with production traits and may be used as candidates for marker-assisted selection (MAS (show MAS1 Antibodies)) and management in beef cattle breeding programs.

Mouse (Murine) Sirtuin 6 (SIRT6) interaction partners

  1. up-regulates AMP (show TMPRSS5 Antibodies)/ATP and then activates the AMPK (show PRKAA1 Antibodies)-FoxO3alpha axis and further initiates the downstream antioxidant-encoding gene expression, thereby decreasing cellular levels of oxidative stress and mediating cardioprotection in the ischemic heart

  2. SIRT6 is important for glucose-stimulated insulin (show INS Antibodies) secretion from pancreatic beta cells and activation of SIRT6 may be useful to improve insulin (show INS Antibodies) secretion in diabetes

  3. These data strongly suggest that overexpression of Sirt6 can prevent osteoarthritis development by reducing both the inflammatory response and chondrocytes senescence.

  4. Sirt6 depletion causes spindle defects and chromosome misalignment during meiosis of mouse oocyte

  5. In SIRT6-deficient mice there is impaired bone remodeling leading to osteopenia.

  6. SIRT6/NF-kappaB (show NFKB1 Antibodies) signaling axis in ginsenoside Rg1 (show PPP1R3A Antibodies)-delayed hematopoietic stem/progenitor cell senescence.

  7. Data showed the expression levels of SIRT1 (show SIRT1 Antibodies), SIRT3 (show SIRT3 Antibodies), and SIRT6 were decreased in the ovaries of aged mice and mice treated with chemotherapy, but increased in mice treated to caloric restriction suggesting these genes are closely related to ovarian reserve.

  8. Sodium sulfide (show SQRDL Antibodies) protected brain endothelial cells against simulated ischemic injury through SIRT6-dependent mechanisms.

  9. SIRT1 (show SIRT1 Antibodies) localizes to the promoters of several aberrantly silenced tumor suppressor genes whose DNA is hypermethylated

  10. Sirt6 has key roles in the relationship among ageing, metabolic syndrome, and osteoarthritis

Sirtuin 6 (SIRT6) Antigen Profile

Protein Summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with anti-Sirtuin 6 (SIRT6) Antibodies

  • sirtuin 6 (sirt6) antibody
  • sirtuin 6 (SIRT6) antibody
  • sirtuin 6 (Sirt6) antibody
  • 2810449N18Rik antibody
  • AI043036 antibody
  • Sir2l6 antibody

Protein level used designations for anti-Sirtuin 6 (SIRT6) Antibodies

sirtuin (silent mating type information regulation 2 homolog) 6 , NAD-dependent deacetylase sirtuin-6 , NAD-dependent protein deacetylase sirtuin-6 , SIR2-like protein 6 , regulatory protein SIR2 homolog 6 , sir2-related protein type 6 , sirtuin type 6

GENE ID SPECIES
444018 Xenopus laevis
428332 Gallus gallus
51548 Homo sapiens
485045 Canis lupus familiaris
100126274 Sus scrofa
535416 Bos taurus
50721 Mus musculus
299638 Rattus norvegicus
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