SIRT6 antibody (AA 276-305)
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- Target See all SIRT6 Antibodies
- SIRT6 (Sirtuin 6 (SIRT6))
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Binding Specificity
- AA 276-305
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This SIRT6 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Purification
- Antigen affinity purified
- Immunogen
- A portion of amino acids 276-305 from the human protein was used as the immunogen for this SIRT6 antibody.
- Isotype
- Ig Fraction
- Top Product
- Discover our top product SIRT6 Primary Antibody
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anti-Sirtuin 6 (SIRT6) (AA 1-334) antibody
SIRT6 Reactivity: Mouse WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Sirtuin 6 (SIRT6) (AA 141-250) antibodySIRT6 Reactivity: Human WB, ELISA, IHC, ICC, FACS Host: Mouse Monoclonal 2G1H1 unconjugated
anti-Sirtuin 6 (SIRT6) antibodySIRT6 Reactivity: Human, Mouse, Rat, Monkey WB, IP, IF Host: Mouse Monoclonal 6C9-D10-D3 unconjugated
anti-Sirtuin 6 (SIRT6) (AA 290-319), (C-Term) antibodySIRT6 Reactivity: Human, Mouse WB, IHC (p) Host: Rabbit Polyclonal RB2109 unconjugated
anti-Sirtuin 6 (SIRT6) (N-Term) antibodySIRT6 Reactivity: Human, Mouse, Rat, Dog, Cow, Pig, Guinea Pig, Horse WB Host: Rabbit Polyclonal unconjugated
anti-Sirtuin 6 (SIRT6) (Middle Region) antibodySIRT6 Reactivity: Human, Rat, Dog, Cow WB, IP, ChIP Host: Rabbit Polyclonal unconjugated
anti-Sirtuin 6 (SIRT6) (AA 35-274) antibodySIRT6 Reactivity: Human WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Sirtuin 6 (SIRT6) (AA 56-105) antibodySIRT6 Reactivity: Human, Mouse, Dog, Monkey, Pig, Bat, Hamster WB, IHC, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Sirtuin 6 (SIRT6) (AA 141-250) antibodySIRT6 Reactivity: Human ELISA Host: Mouse Monoclonal 1D8 unconjugated
anti-Sirtuin 6 (SIRT6) (C-Term) antibodySIRT6 Reactivity: Human WB, IP Host: Rabbit Polyclonal unconjugated
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- Application Notes
- Titration of the SIRT6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- In 1X PBS pH 7.4 with 0.09 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Aliquot the SIRT6 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- Target
- SIRT6 (Sirtuin 6 (SIRT6))
- Alternative Name
- SIRT6 (SIRT6 Products)
- Synonyms
- 2810449N18Rik antibody, AI043036 antibody, Sir2l6 antibody, SIR2L6 antibody, zgc:86729 antibody, sirtuin 6 antibody, sirtuin 6 S homeolog antibody, Sirt6 antibody, SIRT6 antibody, sirt6.S antibody, sirt6 antibody
- Background
- NAD-dependent protein deacetylase. Has deacetylase activity towards 'Lys-9' and 'Lys-56' of histone H3. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates 'Lys-9' of histone H3 at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. Regulates the production of TNF protein (By similarity).
- UniProt
- Q8N6T7
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