anti-Sirtuin 6 (SIRT6) Antibodies

SIRT6 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Additionally we are shipping Sirtuin 6 Proteins (20) and Sirtuin 6 Kits (18) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SIRT6 50721 P59941
SIRT6 51548 Q8N6T7
SIRT6 299638  
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Top anti-Sirtuin 6 Antibodies at antibodies-online.com

Showing 10 out of 218 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated ChIP, IP, WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (fro), IHC (p), IP, WB Detection of SIRT6 in MEF lysate using ABIN250952. Western Blot: SIRT6 Antibody [ABIN250952] - WB analysis of SIRT6 in NIH/3T3 cell lysate. 0.1 mL Log in to see 7 to 9 Days
$444.19
Details
Human Rabbit Un-conjugated IHC (p), WB Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma Western blot analysis of SIRT6 Antibody (C-term) (ABIN390181) in mouse stomach tissue lysates (35 µg/lane). SIRT6 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p) 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB Anti- SIRT6Picoband antibody, IHC(P) IHC(P): Mouse Cardiac Muscle Tissue Anti- SIRT6Picoband antibody, IHC(P) IHC(P): Human Mammary Cancer Tissue 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated ICC, IF, WB Detection of SIRT6 in HeLa whole cell lysate using ABIN250956. Immunocytochemistry/Immunofluorescence: SIRT6 Antibody [ABIN250956] - SIRT6 antibody was tested in Hela cells with DyLight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red). 0.1 mL Log in to see 7 to 9 Days
$444.19
Details
Human Rabbit Un-conjugated WB SIRT6 antibody tested by Western blot. HeLa cells nuclear extract (25 μg) probed with SIRT6 antibody (1:1,000). 100 μL Log in to see 1 to 2 Days
$495.83
Details
Human Rabbit Un-conjugated IHC (p), WB SIRT6 Antibody (C-term) (ABIN657945) western blot analysis in K562 cell line lysates (35 µg/lane). This demonstrates the SIRT6 antibody detected the SIRT6 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Biotin IHC (p), WB   100 μL Log in to see 14 to 21 Days
$405.90
Details

SIRT6 Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-Sirtuin 6 Antibodies

  1. Human Polyclonal SIRT6 Primary Antibody for ICC, IF - ABIN250952 : Sundaresan, Vasudevan, Zhong, Kim, Samant, Parekh, Pillai, Ravindra, Gupta, Jeevanandam, Cunningham, Deng, Lombard, Mostoslavsky, Gupta: The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun. in Nature medicine 2012 (PubMed)
    Show all 11 Pubmed References

  2. Human Polyclonal SIRT6 Primary Antibody for IHC - ABIN967032 : Frye: Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. in Biochemical and biophysical research communications 2000 (PubMed)
    Show all 5 Pubmed References

  3. Human Polyclonal SIRT6 Primary Antibody for IHC - ABIN967033 : Dephoure, Zhou, Villén, Beausoleil, Bakalarski, Elledge, Gygi: A quantitative atlas of mitotic phosphorylation. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)
    Show all 5 Pubmed References

  4. Human Monoclonal SIRT6 Primary Antibody for ELISA - ABIN526804 : Grimley, Polyakova, Vamathevan, McKenary, Hayes, Patel, Smith, Bridges, Fosberry, Bhardwaja, Mouzon, Chung, Barrett, Richmond, Modha, Solari: Over expression of wild type or a catalytically dead mutant of Sirtuin 6 does not influence NF?B responses. in PLoS ONE 2012 (PubMed)
    Show all 2 Pubmed References

  5. Cow (Bovine) Polyclonal SIRT6 Primary Antibody for ChIP, IP - ABIN2779624 : Wajapeyee, Malonia, Palakurthy, Green: Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors. in Genes & development 2013 (PubMed)
    Show all 2 Pubmed References

  6. Human Polyclonal SIRT6 Primary Antibody for IHC (p), WB - ABIN390181 : Wu, Liu, Fu, Liu, Zhou: Direct evidence of sirtuin downregulation in the liver of non-alcoholic fatty liver disease patients. in Annals of clinical and laboratory science 2014 (PubMed)
    Show all 2 Pubmed References

  7. Human Polyclonal SIRT6 Primary Antibody for ICC, IF - ABIN250956 : Benavente, Schnell, Jacobson: Effects of niacin restriction on sirtuin and PARP responses to photodamage in human skin. in PLoS ONE 2012 (PubMed)

  8. Human Polyclonal SIRT6 Primary Antibody for WB - ABIN2668661 : Rajendran, Kidane, Yu, Dashwood, Bisson, Löhr, Ho, Williams, Dashwood: HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. in Epigenetics 2013 (PubMed)

  9. Human Polyclonal SIRT6 Primary Antibody for IF (p), IHC (p) - ABIN712481 : Thirumurthi, Shen, Xia, LaBaff, Wei, Li, Chang, Chen, Lin, Yu, Hung: MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer. in Science signaling 2014 (PubMed)

More Antibodies against Sirtuin 6 Interaction Partners

Mouse (Murine) Sirtuin 6 (SIRT6) interaction partners

  1. Sirt6 inhibits Notch1 (show NOTCH1 Antibodies) and Notch4 (show NOTCH4 Antibodies) transcription by deacetylating histone H3K9.

  2. Sirt6 is downregulated in induced pluripotent stem cells from old mice.

  3. post-translational modification facilitates the mobilization of SIRT6 to DNA damage sites and is required for efficient recruitment of poly (ADP-ribose) polymerase 1 (PARP1 (show PARP1 Antibodies)) to DNA break sites and for efficient repair of double-strand break.

  4. SIRT6 and its downstream signaling could be targeted in Alzheimer's disease and age-related neurodegeneration.

  5. These findings reveal a crucial role of SIRT6 in adipogenesis and provide potential therapeutic targets for obesity.

  6. Global and endothelium-specific SIRT6 knockout mice exhibited impaired endothelium-dependent vasorelaxation. Moreover, SIRT6(+/-) haploinsufficient mice fed a high-fat diet (HFD) also displayed impaired endothelium-dependent vasorelaxation. Importantly, SIRT6(+/-); ApoE(-/-) mice after HFD feeding had exacerbated atherosclerotic lesion development, concurrent with increased expression of proinflammatory cytokine VCAM-1.

  7. these data provide compelling evidence that Sirt6 is important for podocyte homeostasis and maintenance of glomerular function

  8. The mice with SIRT6 deficiency in muscle displayed impaired glucose homeostasis and insulin (show INS Antibodies) sensitivity, attenuated whole body energy expenditure, and weakened exercise performance. Results from both gain- and loss-of-function experiments identify SIRT6 as a physiological regulator of muscle mitochondrial function.

  9. Study investigated the involvement of SIRT6 in adult hippocampal neurogenesis. Mice over-expressing Sirt6 exhibit increased numbers of young neurons and decreased numbers of mature neurons, without affecting glial differentiation.

  10. Sirt6 deletion in macrophages promoted the activation of nuclear factor-kappaB (NF-kappaB (show NFKB1 Antibodies)) and endogenous production of interleukin-6 (show IL6 Antibodies), which led to STAT3 (show STAT3 Antibodies) activation and the positive feedback circuits for NF-kappaB (show NFKB1 Antibodies) stimulation; this cross talk expedited an M1 polarization

Human Sirtuin 6 (SIRT6) interaction partners

  1. in vitro and in vivo studies showed that gene silencing of SIRT6 suppressed cell proliferation and promoted cellular apoptosis by activating the Bax (show BAX Antibodies)-dependent apoptotic signal pathway in Hepatocellular Carcinoma cells. Furthermore, SIRT6 knockdown could increase liver cancer cell sensitivity to chemotherapy drug doxorubicin. SIRT6 is an important protumorigenic factor in liver carcinogenesis.

  2. SIRT6 is upregulated in non-small cell lung cancer; it may have a functional role in promoting migration and invasion through ERK1/2 (show MAPK1/3 Antibodies)/MMP9 (show MMP9 Antibodies) signaling

  3. Sirt6 inhibits Notch1 (show NOTCH1 Antibodies) and Notch4 (show NOTCH4 Antibodies) transcription by deacetylating histone H3K9.

  4. These data provide the first evidence of the Egt ability to interfere with endothelial senescence linked to hyperglycaemia through the regulation of SIRT1 (show SIRT1 Antibodies) and SIRT6 signaling, thus further strengthening the already assessed role of these two histone deacetylases in type 2 diabetes.

  5. Study shows that SIRT6 protein levels are lower in patients with prediabetes (PreDM) and type 2 diabetes mellitus (T2DM) and implies that SIRT6 may take play in development T2DM by altering the expression of genes involved in glucose metabolism through histone modification rather than its role in DNA repair.

  6. Low SIRT6 expression is associated with bone marrow metastasis in neuroblastoma (show ARHGEF16 Antibodies).

  7. SIRT6 overexpression suppresses PI3K (show PIK3CA Antibodies) signaling.

  8. post-translational modification facilitates the mobilization of SIRT6 to DNA damage sites and is required for efficient recruitment of poly (ADP-ribose) polymerase 1 (PARP1 (show PARP1 Antibodies)) to DNA break sites and for efficient repair of double-strand break.

  9. SIRT6 and its downstream signaling could be targeted in Alzheimer's disease and age-related neurodegeneration.

  10. Loss- and gain-of-SIRT6 function studies in cultured human endothelial cells (ECs) showed that SIRT6 attenuated monocyte adhesion to ECs.

Cow (Bovine) Sirtuin 6 (SIRT6) interaction partners

  1. results suggest that some polymorphisms in SIRT6 are associated with production traits and may be used as candidates for marker-assisted selection (MAS (show MAS1 Antibodies)) and management in beef cattle breeding programs.

Sirtuin 6 (SIRT6) Antigen Profile

Protein Summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with anti-Sirtuin 6 (SIRT6) Antibodies

  • sirtuin 6 (Sirt6) antibody
  • sirtuin 6 (SIRT6) antibody
  • sirtuin 6 S homeolog (sirt6.S) antibody
  • sirtuin 6 (sirt6) antibody
  • 2810449N18Rik antibody
  • AI043036 antibody
  • SIR2L6 antibody
  • zgc:86729 antibody

Protein level used designations for anti-Sirtuin 6 (SIRT6) Antibodies

NAD-dependent deacetylase sirtuin-6 , NAD-dependent protein deacetylase sirtuin-6 , SIR2-like protein 6 , regulatory protein SIR2 homolog 6 , sir2-related protein type 6 , sirtuin type 6 , sirtuin (silent mating type information regulation 2 homolog) 6

GENE ID SPECIES
50721 Mus musculus
51548 Homo sapiens
299638 Rattus norvegicus
428332 Gallus gallus
535416 Bos taurus
100126274 Sus scrofa
444018 Xenopus laevis
485045 Canis lupus familiaris
100734667 Cavia porcellus
415161 Danio rerio
737026 Pan troglodytes
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