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SIRT6 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Additionally we are shipping Sirtuin 6 Proteins (21) and Sirtuin 6 Kits (16) and many more products for this protein.
Showing 10 out of 217 products:
Human Polyclonal SIRT6 Primary Antibody for ICC, IF - ABIN250952
Sundaresan, Vasudevan, Zhong, Kim, Samant, Parekh, Pillai, Ravindra, Gupta, Jeevanandam, Cunningham, Deng, Lombard, Mostoslavsky, Gupta: The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun. in Nature medicine 2012
Show all 11 Pubmed References
Human Polyclonal SIRT6 Primary Antibody for IHC - ABIN967032
Frye: Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. in Biochemical and biophysical research communications 2000
Show all 5 Pubmed References
Human Polyclonal SIRT6 Primary Antibody for IHC - ABIN967033
Dephoure, Zhou, Villén, Beausoleil, Bakalarski, Elledge, Gygi: A quantitative atlas of mitotic phosphorylation. in Proceedings of the National Academy of Sciences of the United States of America 2008
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Human Monoclonal SIRT6 Primary Antibody for ELISA - ABIN526804
Grimley, Polyakova, Vamathevan, McKenary, Hayes, Patel, Smith, Bridges, Fosberry, Bhardwaja, Mouzon, Chung, Barrett, Richmond, Modha, Solari: Over expression of wild type or a catalytically dead mutant of Sirtuin 6 does not influence NF?B responses. in PLoS ONE 2012
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Cow (Bovine) Polyclonal SIRT6 Primary Antibody for ChIP, IP - ABIN2779624
Wajapeyee, Malonia, Palakurthy, Green: Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors. in Genes & development 2013
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Human Polyclonal SIRT6 Primary Antibody for IHC (p), WB - ABIN390181
Wu, Liu, Fu, Liu, Zhou: Direct evidence of sirtuin downregulation in the liver of non-alcoholic fatty liver disease patients. in Annals of clinical and laboratory science 2014
Show all 2 Pubmed References
Human Polyclonal SIRT6 Primary Antibody for WB - ABIN2668661
Rajendran, Kidane, Yu, Dashwood, Bisson, Löhr, Ho, Williams, Dashwood: HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. in Epigenetics 2013
Human Polyclonal SIRT6 Primary Antibody for IHC (p), WB - ABIN712483
Thirumurthi, Shen, Xia, LaBaff, Wei, Li, Chang, Chen, Lin, Yu, Hung: MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer. in Science signaling 2014
Human Polyclonal SIRT6 Primary Antibody for ICC, IF - ABIN250956
Benavente, Schnell, Jacobson: Effects of niacin restriction on sirtuin and PARP responses to photodamage in human skin. in PLoS ONE 2012
The expression of SIRT6 was reduced during cellular senescence, whereas enforced SIRT6 expression promoted cell proliferation and antagonized cellular senescence.Furthermore, SIRT6 directly interacted with p27 (show PAK2 Antibodies). Finally, SIRT6 markedly rescued senescence induced by p27 (show PAK2 Antibodies).
Previously unknown reciprocal influence of SIRT6 and HK2 (show HK2 Antibodies) in regulating autophagy driven monocyte differentiation.
our findings describe TRF2 (show TERF2 Antibodies) as a novel SIRT6 substrate and demonstrate that acetylation of TRF2 (show TERF2 Antibodies) plays a crucial role in the regulation of TRF2 (show TERF2 Antibodies) protein stability, thus providing a new route for modulating its expression level during oncogenesis and damage response.
SIRT6 over-expression establishes a condition whereby reconfiguration of the Hexokinase 2 (show HK2 Antibodies) promoter chromatin structure makes it receptive to interaction with MZF1 (show ZFP42 Antibodies)/SIRT6 complex, thereby favouring a regulatory state conducive to diminished transcription
This study demonstrates that CSNK2A1 (show CSNK2A1 Antibodies) and SIRT6 are indicators of poor prognosis for breast carcinomas and that CSNK2A1 (show CSNK2A1 Antibodies)-mediated phosphorylation of SIRT6 might be involved in the progression of breast carcinoma.
Thus, these results reveal that SUMOylation has an important role in regulation of Sirt6 deacetylation on H3K56, as well as its tumor suppressive activity.
HBx increased signs of DNA damage such as accumulation of 8-hydroxy-2'-deoxyguanosine and comet formation, which were reversed by overexpression of PARP1 (show PARP1 Antibodies) and/or Sirt6..physical interaction of HBx and PARP1 (show PARP1 Antibodies) accelerates DNA damage by inhibiting recruitment of the DNA repair complex to the damaged DNA sites, which may lead to the onset of hepatocarcinogenesis
Data suggest, in macrophages, SIRT6 plays role in preventing atherosclerosis by reducing foam cell formation via autophagy-dependent pathway involving regulation of expression of ATG5 (show ATG5 Antibodies), LC3B (show MAP1LC3B Antibodies), LAMP1 (show LAMP1 Antibodies), ABCA1 (show ABCA1 Antibodies), ABCG1 (show ABCG1 Antibodies), and MIRN33. (ATG5 (show ATG5 Antibodies) = autophagy-related protein 5 (show CAPS Antibodies); LC3B (show MAP1LC3B Antibodies) = microtubule-associated protein 1 light chain 3 beta (show MAP1LC3B Antibodies); LAMP1 (show LAMP1 Antibodies) = lysosomal-associated membrane protein 1 (show LAMP1 Antibodies); ABCA1 (show ABCA1 Antibodies)/ABCG1 (show ABCG1 Antibodies) = ATP-binding cassette transporters 1/8)
These findings reveal a previously unknown role for nasal mucosa steady-state conditions in the control of Sirt6 activity, and provide evidence for a relationship between HMGB1 (show HMGB1 Antibodies) and Sirt6 in chronic rhinosinusitis with nasal polyps (CRSwNP), and promising benefits of glycyrrhetinic acid for CRSwNP patients.
In obese patients, the expression of Sirt6 expression is reduced.
results suggest that some polymorphisms in SIRT6 are associated with production traits and may be used as candidates for marker-assisted selection (MAS (show MAS1 Antibodies)) and management in beef cattle breeding programs.
these data provide compelling evidence that Sirt6 is important for podocyte homeostasis and maintenance of glomerular function
The mice with SIRT6 deficiency in muscle displayed impaired glucose homeostasis and insulin (show INS Antibodies) sensitivity, attenuated whole body energy expenditure, and weakened exercise performance. Results from both gain- and loss-of-function experiments identify SIRT6 as a physiological regulator of muscle mitochondrial function.
Study investigated the involvement of SIRT6 in adult hippocampal neurogenesis. Mice over-expressing Sirt6 exhibit increased numbers of young neurons and decreased numbers of mature neurons, without affecting glial differentiation.
Sirt6 deletion in macrophages promoted the activation of nuclear factor-kappaB (NF-kappaB (show NFKB1 Antibodies)) and endogenous production of interleukin-6 (show IL6 Antibodies), which led to STAT3 (show STAT3 Antibodies) activation and the positive feedback circuits for NF-kappaB (show NFKB1 Antibodies) stimulation; this cross talk expedited an M1 polarization
These data suggest that the function of SIRT6 in the Fabp4 (show FABP4 Antibodies)-Cre-expressing cells in addition to mature adipocytes plays a critical role in body weight maintenance and metabolic homeostasis.
a physiological defects in adult SIRT6-/- mice
In mouse retinae lacking Sirt6, effectors of glycolytic flux were dramatically increased, leading to upregulation of key intermediates in glycolysis, TCA cycle, and glutaminolysis.
It has been demonstrated that Sirt6 plays a role in tooth root formation, and it was confirmed that SIRT6 is necessary for dental mesenchymal cells differentiation as well as for the development of the tooth root and for eventual tooth eruption.
Fat-specific Sirt6 knockout (FKO) sensitized mice to high-fat diet-induced obesity, which was attributed to adipocyte hypertrophy rather than adipocyte hyperplasia. Fat-specific Sirt6 KO also increased inflammation in the adipose tissue, which may have contributed to insulin (show INS Antibodies) resistance in high-fat diet-fed FKO mice.
SIRT6 is a primary negative regulation factor in endothelial dysfunction and atherosclerosis development.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.
sirtuin (silent mating type information regulation 2 homolog) 6
, NAD-dependent deacetylase sirtuin-6
, NAD-dependent protein deacetylase sirtuin-6
, SIR2-like protein 6
, regulatory protein SIR2 homolog 6
, sir2-related protein type 6
, sirtuin type 6