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anti-Sirtuin 6 (SIRT6) Antibodies

SIRT6 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Additionally we are shipping Sirtuin 6 Proteins (24) and Sirtuin 6 Kits (14) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SIRT6 51548 Q8N6T7
SIRT6 50721 P59941
SIRT6 299638  
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Top anti-Sirtuin 6 Antibodies at

Showing 10 out of 213 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated EIA, IHC (p) 0.4 mL Log in to see 6 to 8 Days
Chicken Rabbit Un-conjugated WB WB Suggested Anti-SIRT6 Antibody Titration: 1.25ug/mlPositive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated IHC (p), WB Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma Western blot analysis of SIRT6 Antibody (C-term) (ABIN390181) in mouse stomach tissue lysates (35 µg/lane). SIRT6 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
Human Chicken Un-conjugated EIA, WB Western blot analysis of SIRT6 in HeLa cell lysate with SIRT6 antibody at (A) 0.5 and (B) 1 μg/ml. 0.1 mg Log in to see 6 to 8 Days
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (fro), IHC (p), IP, WB Detection of SIRT6 in MEF lysate using ABIN250952. Western Blot: SIRT6 Antibody [ABIN250952] - WB analysis of SIRT6 in NIH/3T3 cell lysate. 0.1 mL Log in to see 5 to 7 Days
Human Rabbit Un-conjugated ICC, IF, WB Detection of SIRT6 in HeLa whole cell lysate using ABIN250956. Immunocytochemistry/Immunofluorescence: SIRT6 Antibody [ABIN250956] - SIRT6 antibody was tested in Hela cells with DyLight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red). 0.1 mL Log in to see 5 to 7 Days
Human Rabbit Un-conjugated WB SIRT6 antibody tested by Western blot. HeLa cells nuclear extract (25 μg) probed with SIRT6 antibody (1:1,000). 100 μL Log in to see 1 to 2 Days
Human Mouse Un-conjugated IF, WB Anti-SIRT6 mouse monoclonal antibody (ABIN2455114) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SIRT6 (RC202833). HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SIRT6 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-SIRT6. 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated IHC (p), WB SIRT6 Antibody (C-term) (ABIN657945) western blot analysis in K562 cell line lysates (35 µg/lane). This demonstrates the SIRT6 antibody detected the SIRT6 protein (arrow). 400 μL Log in to see 10 to 11 Days

SIRT6 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Sirtuin 6 Antibodies

  1. Human Polyclonal SIRT6 Primary Antibody for ICC, IF - ABIN250952 : Sundaresan, Vasudevan, Zhong, Kim, Samant, Parekh, Pillai, Ravindra, Gupta, Jeevanandam, Cunningham, Deng, Lombard, Mostoslavsky, Gupta: The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun. in Nature medicine 2012 (PubMed)
    Show all 10 references for ABIN250952

  2. Cow (Bovine) Polyclonal SIRT6 Primary Antibody for WB - ABIN2779624 : Wajapeyee, Malonia, Palakurthy, Green: Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors. in Genes & development 2013 (PubMed)
    Show all 2 references for ABIN2779624

  3. Human Polyclonal SIRT6 Primary Antibody for IHC (p), WB - ABIN390181 : Wu, Liu, Fu, Liu, Zhou: Direct evidence of sirtuin downregulation in the liver of non-alcoholic fatty liver disease patients. in Annals of clinical and laboratory science 2014 (PubMed)
    Show all 2 references for ABIN390181

  4. Human Polyclonal SIRT6 Primary Antibody for EIA, WB - ABIN783616 : Salminen, Kaarniranta: SIRT1: regulation of longevity via autophagy. in Cellular signalling 2009 (PubMed)
    Show all 2 references for ABIN783616

  5. Human Polyclonal SIRT6 Primary Antibody for EIA, IHC (p) - ABIN358735 : Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: Complete sequencing and characterization of 21,243 full-length human cDNAs. ... in Nature genetics 2003 (PubMed)
    Show all 2 references for ABIN358735

  6. Human Polyclonal SIRT6 Primary Antibody for WB - ABIN2668661 : Rajendran, Kidane, Yu, Dashwood, Bisson, Löhr, Ho, Williams, Dashwood: HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. in Epigenetics 2013 (PubMed)

  7. Human Polyclonal SIRT6 Primary Antibody for ICC, IF - ABIN250956 : Benavente, Schnell, Jacobson: Effects of niacin restriction on sirtuin and PARP responses to photodamage in human skin. in PLoS ONE 2012 (PubMed)

  8. Chicken Polyclonal SIRT6 Primary Antibody for WB - ABIN2779625 : Frye: Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. in Biochemical and biophysical research communications 2000 (PubMed)

More Antibodies against Sirtuin 6 Interaction Partners

Human Sirtuin 6 (SIRT6) interaction partners

  1. SIRT6, TNF-alpha (show TNF Antibodies), and IFN-gamma (show IFNG Antibodies) were significantly higher in lesional than perilesional and control skin.

  2. this study shoes that through the antiglycolytic activity of SIRT6, the autophagy is suppressed, which is beneficial to nasal polyp formation

  3. The promoter regions of the SIRT6 gene were genetically analyzed in large cohorts of MI patients (n = 371) and ethnically-matched controls (n = 383). Results: A total of 15 DNA sequence variants (DSVs) were identified, including seven single-nucleotide polymorphisms (SNPs). Two novel heterozygous DSVs, g.4183823G>C and g.4183742G>A, were identified in two MI patients but in none of the controls.

  4. we examined the role and mechanisms of SIRT6 in suppressing postoperative epidural scar formation. We showed that SIRT6 promoted the expression of miR (show MLXIP Antibodies)-21 and then suppressed TGF-beta2 (show TGFB2 Antibodies) expression in a targeted manner.

  5. SIRT6 induced autophagy via attenuation of AKT signaling and treatment with autophagy inhibitor 3-MA or knockdown of autophagy-related protein Atg5 rescued H2O2-induced neuronal injury.

  6. Data indicate that compared to non-neoplastic endometria (NNE (show ENO1 Antibodies)), endometrial cancer (EC) showed SIRT7 (show SIRT7 Antibodies) mRNA overexpression, whereas SIRT1 (show SIRT1 Antibodies), SIRT2 (show SIRT2 Antibodies), SIRT4 (show SIRT4 Antibodies) and SIRT5 (show SIRT5 Antibodies) were underexpressed, and no significant differences were observed for SIRT3 (show SIRT3 Antibodies) and SIRT6.

  7. SIRT6 as an important pancreatic ductal adenocarcinoma tumor suppressor

  8. Tissue micro-array studies confirmed the higher levels of SIRT6 in both prostate tumor tissues and prostate cancer cells than in their normal counterparts. Knockdown of SIRT6 in human prostate cancer cells led to sub-G1 phase arrest of cell cycle, increased apoptosis, elevated DNA damage level and decrease in BCL2 (show BCL2 Antibodies) gene expression.

  9. Results find no significant association between common polymorphisms and haplotypes in the SIRT6 gene and longevity.

  10. Data provided evidence that SIRT6 tagSNPs rs352493 and rs3760908 play significant roles in the severity of coronary artery disease (CAD (show CAD Antibodies)) in Chinese Han subjects, which might be useful predictors of the severity of CAD (show CAD Antibodies).

Cow (Bovine) Sirtuin 6 (SIRT6) interaction partners

  1. results suggest that some polymorphisms in SIRT6 are associated with production traits and may be used as candidates for marker-assisted selection (MAS (show MAS1 Antibodies)) and management in beef cattle breeding programs.

Mouse (Murine) Sirtuin 6 (SIRT6) interaction partners

  1. Sirt6 binds to promoters of NKG2D (show KLRK1 Antibodies) ligand genes and regulates the H3K9 and H3K56 acetylation levels

  2. The critical role of SIRT6 on aging and inflammation.

  3. The SIRT6 regulates HSC (show FUT1 Antibodies) homeostasis through the transcriptional repression of Wnt (show WNT2 Antibodies) target genes. Sirt6 deletion promoted HSC (show FUT1 Antibodies) proliferation through aberrant activation of Wnt (show WNT2 Antibodies) signaling.

  4. Sirt6 plays a crucial role in dendritic cell differentiation and function and reduced Sirt6 activity may contribute to immunosenescence.

  5. up-regulates AMP (show TMPRSS5 Antibodies)/ATP and then activates the AMPK (show PRKAA1 Antibodies)-FoxO3alpha axis and further initiates the downstream antioxidant-encoding gene expression, thereby decreasing cellular levels of oxidative stress and mediating cardioprotection in the ischemic heart

  6. SIRT6 is important for glucose-stimulated insulin (show INS Antibodies) secretion from pancreatic beta cells and activation of SIRT6 may be useful to improve insulin (show INS Antibodies) secretion in diabetes

  7. These data strongly suggest that overexpression of Sirt6 can prevent osteoarthritis development by reducing both the inflammatory response and chondrocytes senescence.

  8. Sirt6 depletion causes spindle defects and chromosome misalignment during meiosis of mouse oocyte

  9. In SIRT6-deficient mice there is impaired bone remodeling leading to osteopenia.

  10. SIRT6/NF-kappaB (show NFKB1 Antibodies) signaling axis in ginsenoside Rg1 (show PPP1R3A Antibodies)-delayed hematopoietic stem/progenitor cell senescence.

Sirtuin 6 (SIRT6) Antigen Profile

Protein Summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with anti-Sirtuin 6 (SIRT6) Antibodies

  • sirtuin 6 (sirt6) antibody
  • sirtuin 6 (SIRT6) antibody
  • sirtuin 6 (Sirt6) antibody
  • 2810449N18Rik antibody
  • AI043036 antibody
  • Sir2l6 antibody

Protein level used designations for anti-Sirtuin 6 (SIRT6) Antibodies

sirtuin (silent mating type information regulation 2 homolog) 6 , NAD-dependent deacetylase sirtuin-6 , NAD-dependent protein deacetylase sirtuin-6 , SIR2-like protein 6 , regulatory protein SIR2 homolog 6 , sir2-related protein type 6 , sirtuin type 6

444018 Xenopus laevis
428332 Gallus gallus
51548 Homo sapiens
485045 Canis lupus familiaris
100126274 Sus scrofa
535416 Bos taurus
50721 Mus musculus
299638 Rattus norvegicus
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