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SIRT6 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Additionally we are shipping Sirtuin 6 Proteins (21) and Sirtuin 6 Kits (15) and many more products for this protein.
Showing 10 out of 211 products:
Human Polyclonal SIRT6 Primary Antibody for ICC, IF - ABIN250952
Sundaresan, Vasudevan, Zhong, Kim, Samant, Parekh, Pillai, Ravindra, Gupta, Jeevanandam, Cunningham, Deng, Lombard, Mostoslavsky, Gupta: The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun. in Nature medicine 2012
Show all 11 references for 250952
Cow (Bovine) Polyclonal SIRT6 Primary Antibody for ChIP, IP - ABIN2779624
Wajapeyee, Malonia, Palakurthy, Green: Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors. in Genes & development 2013
Show all 2 references for 2779624
Human Polyclonal SIRT6 Primary Antibody for IHC (p), WB - ABIN390181
Wu, Liu, Fu, Liu, Zhou: Direct evidence of sirtuin downregulation in the liver of non-alcoholic fatty liver disease patients. in Annals of clinical and laboratory science 2014
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Human Polyclonal SIRT6 Primary Antibody for EIA, IHC (p) - ABIN358735
Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: Complete sequencing and characterization of 21,243 full-length human cDNAs. ... in Nature genetics 2003
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Human Polyclonal SIRT6 Primary Antibody for WB - ABIN2668661
Rajendran, Kidane, Yu, Dashwood, Bisson, Löhr, Ho, Williams, Dashwood: HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. in Epigenetics 2013
Human Polyclonal SIRT6 Primary Antibody for ICC, IF - ABIN250956
Benavente, Schnell, Jacobson: Effects of niacin restriction on sirtuin and PARP responses to photodamage in human skin. in PLoS ONE 2012
Cow (Bovine) Polyclonal SIRT6 Primary Antibody for WB - ABIN2779625
Frye: Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. in Biochemical and biophysical research communications 2000
Thus, these results reveal that SUMOylation has an important role in regulation of Sirt6 deacetylation on H3K56, as well as its tumor suppressive activity.
HBx increased signs of DNA damage such as accumulation of 8-hydroxy-2'-deoxyguanosine and comet formation, which were reversed by overexpression of PARP1 (show PARP1 Antibodies) and/or Sirt6..physical interaction of HBx and PARP1 (show PARP1 Antibodies) accelerates DNA damage by inhibiting recruitment of the DNA repair complex to the damaged DNA sites, which may lead to the onset of hepatocarcinogenesis
Data suggest, in macrophages, SIRT6 plays role in preventing atherosclerosis by reducing foam cell formation via autophagy-dependent pathway involving regulation of expression of ATG5 (show ATG5 Antibodies), LC3B (show MAP1LC3B Antibodies), LAMP1 (show LAMP1 Antibodies), ABCA1 (show ABCA1 Antibodies), ABCG1 (show ABCG1 Antibodies), and MIRN33. (ATG5 (show ATG5 Antibodies) = autophagy-related protein 5 (show CAPS Antibodies); LC3B (show MAP1LC3B Antibodies) = microtubule-associated protein 1 light chain 3 beta (show MAP1LC3B Antibodies); LAMP1 (show LAMP1 Antibodies) = lysosomal-associated membrane protein 1 (show LAMP1 Antibodies); ABCA1 (show ABCA1 Antibodies)/ABCG1 (show ABCG1 Antibodies) = ATP-binding cassette transporters 1/8)
These findings reveal a previously unknown role for nasal mucosa steady-state conditions in the control of Sirt6 activity, and provide evidence for a relationship between HMGB1 (show HMGB1 Antibodies) and Sirt6 in chronic rhinosinusitis with nasal polyps (CRSwNP), and promising benefits of glycyrrhetinic acid for CRSwNP patients.
In obese patients, the expression of Sirt6 expression is reduced.
positive regulator of aldose reductase (show AKR1B1 Antibodies) expression in U937 and HeLa cells under osmotic stress
these results suggest that SIRT6 enhances cell aggressiveness in PTC (show F9 Antibodies) via BRAF (show BRAF Antibodies)/ERK (show EPHB2 Antibodies)/Mcl1 (show MCL1 Antibodies) pathway, and thus may be a promising target in the treatment of the disease.
our studies shed insights into the crucial functions of sirtuin 6 in esophageal carcinoma cells and provide evidence supporting sirtuin 6-based personalized therapies in esophageal carcinoma cell patients
SIRT6 promotes deacetylation of a new substrate, residue K18 (show KRT18 Antibodies) of histone H3 (show HIST3H3 Antibodies) (H3K18), and inactivation of SIRT6 in cells leads to H3K18 hyperacetylation and aberrant accumulation of pericentric transcripts.
Data show that the increased acetylation of Ku autoantigen 70kDa (Ku70 (show XRCC6 Antibodies)) in sirtuin 6 protein (SIRT6)-depleted cells disrupt its interaction with Bax (show BAX Antibodies) apoptosis regulator protein (Bax (show BAX Antibodies)), which finally resulted in Bax (show BAX Antibodies) mitochondrial translocalization.
results suggest that some polymorphisms in SIRT6 are associated with production traits and may be used as candidates for marker-assisted selection (MAS (show MAS1 Antibodies)) and management in beef cattle breeding programs.
These data suggest that the function of SIRT6 in the Fabp4 (show FABP4 Antibodies)-Cre-expressing cells in addition to mature adipocytes plays a critical role in body weight maintenance and metabolic homeostasis.
a physiological defects in adult SIRT6-/- mice
In mouse retinae lacking Sirt6, effectors of glycolytic flux were dramatically increased, leading to upregulation of key intermediates in glycolysis, TCA cycle, and glutaminolysis.
It has been demonstrated that Sirt6 plays a role in tooth root formation, and it was confirmed that SIRT6 is necessary for dental mesenchymal cells differentiation as well as for the development of the tooth root and for eventual tooth eruption.
Fat-specific Sirt6 knockout (FKO) sensitized mice to high-fat diet-induced obesity, which was attributed to adipocyte hypertrophy rather than adipocyte hyperplasia. Fat-specific Sirt6 KO also increased inflammation in the adipose tissue, which may have contributed to insulin (show INS Antibodies) resistance in high-fat diet-fed FKO mice.
SIRT6 is a primary negative regulation factor in endothelial dysfunction and atherosclerosis development.
Data suggest that expression of Sirt6 in pancreatic beta cells protects against dysfunction (loss of hyperglycemia-induced insulin (show INS Antibodies) secretion) and apoptosis; Sirt6 appears to protect beta cells against the oxidative stress of diabetes type 2 and of cellular aging.
SIRT6, a sirtuin (show SIRT1 Antibodies) with established tumor suppressor function, regulates the lysine fatty acylation of R-Ras2.
data indicate that distinct activities of SIRT6 regulate different pathways and that the G60A mutant is a useful tool to study the contribution of defatty-acylase (show ACY1 Antibodies) activity to SIRT6's various functions
Sirt6 binds to promoters of NKG2D (show KLRK1 Antibodies) ligand genes and regulates the H3K9 and H3K56 acetylation levels
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.
sirtuin (silent mating type information regulation 2 homolog) 6
, NAD-dependent deacetylase sirtuin-6
, NAD-dependent protein deacetylase sirtuin-6
, SIR2-like protein 6
, regulatory protein SIR2 homolog 6
, sir2-related protein type 6
, sirtuin type 6