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Tight Junction Protein 1 (Zona Occludens 1) Proteins (TJP1)

TJP1 encodes a protein located on a cytoplasmic membrane surface of intercellular tight junctions. Additionally we are shipping TJP1 Antibodies (91) and TJP1 Kits (32) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TJP1 7082 Q07157
Mouse TJP1 TJP1 21872 P39447
Rat TJP1 TJP1 292994  
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Top TJP1 Proteins at

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Dog His tag 50 μg Log in to see 21 to 26 Days
HOST_Wheat germ Human GST tag   25 μg Log in to see 9 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

TJP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

More Proteins for Tight Junction Protein 1 (Zona Occludens 1) (TJP1) Interaction Partners

Human Tight Junction Protein 1 (Zona Occludens 1) (TJP1) interaction partners

  1. The frequency of alleles and genotypes of rs2291166 gene polymorphism TJP1 was determined in the Mexico Mestizos population. The ancestral allele was the most prevalent. The conformational effect of this amino acid change was performed in silico.

  2. We identified potential nuclear and membrane biomarkers (increased expression of ZO-1, caveolin-1 (show CAV1 Proteins) and P2X7 receptor (show P2RX7 Proteins)) of risks for placenta and pregnancy

  3. OCLN (show OCLN Proteins) and ZO1 levels appear to be early prognostic markers in patients suffering from sepsis.

  4. The data suggest that ZO-1, along with CD38 and Zap-70 (show ZAP70 Proteins), plays a role in cell cycle regulation in chronic B cell leukemia, and may be used as a prognostic marker in the disease monitoring.

  5. These data provide the first evidence that beta-catenin (show CTNNB1 Proteins) and ZO-1 are direct targets of E7 of the oncogenic beta-human papillomavirus types 5 and 8.

  6. Report TNF-alpha (show TNF Proteins)/Il6 (show IL6 Proteins) mediated dysregulation of zonula occludens-1 properties in human brain microvascular endothelium.

  7. upon specific knockdown of the accessory TJP, ZO-1, undifferentiated NSCs showed decreased levels of key stem cell markers

  8. HTT (show HTT Proteins) may inhibit breast tumor dissemination through maintenance of ZO1 at tight junctions.

  9. These results suggest that the localization of ZO-1 in cell-cell contacts is differently regulated by activation and inhibition of JNK (show MAPK8 Proteins) and/or p38 MAPK (show MAPK14 Proteins) depending on the incubation period.

  10. CFTR (show CFTR Proteins) colocalizes with ZO-1 at the tight junctions of trachea and epididymis, and is expressed before ZO-1 in Wolffian ducts.

Mouse (Murine) Tight Junction Protein 1 (Zona Occludens 1) (TJP1) interaction partners

  1. Cx43 (show GJA1 Proteins) tethers the F-actin cytoskeleton through a ZO-1 linker and supports cell spreading and exploration during locomotion in cerebral endothelial cells.

  2. Expression of Podocalyxin (show PODXL Proteins), which positively regulates the formation of microvilli and the apical membrane, is repressed in embryoid bodies lacking both ZO-1 and ZO-2 (show TJP2 Proteins) and this correlates with an aberrant submembranous localization of Ezrin (show EZR Proteins).

  3. Zonula occludens-1, occludin (show OCLN Proteins) and E-cadherin (show CDH1 Proteins) expression and organization in salivary glands

  4. Tjp1 expression was decreased in glomerular diseases in human and animal models, our results indicate that the suppression of Tjp1 could directly aggravate glomerular disorders, highlights Tjp1 as a potential therapeutic target.

  5. Arecoline increases the production of TNF-alpha (show TNF Proteins) and induces protein redistribution of ZO-1.

  6. Vcl (show VCL Proteins) plays a crucial role in stabilizing gap junctions and myocyte integrity through direct interactions with ZO-1 and stabilization of CX43 (show GJA1 Proteins).

  7. Activation of RhoA (show RHOA Proteins)/ROCK1 (show ROCK1 Proteins) by high glucose in diabetic nephropathy disrupts the expression and translocation of occludin (show OCLN Proteins)/ZO-1, which can be corrected by simvastatin.

  8. Vascular endothelial tight junctions and barrier function are disrupted by 15(S)-hydroxyeicosatetraenoic acid partly via protein kinase C epsilon (show PRKCE Proteins)-mediated zona occludens-1 phosphorylation at threonine 770/772.

  9. The JAM-A (show F11R Proteins) and ZO-1 genes were highly expressed in all the tested tissues.

  10. The results establish that ZO-1 acts as a true scaffolding protein and that the coordinated activity of multiple domains is required for normal TJ structure and function.

Cow (Bovine) Tight Junction Protein 1 (Zona Occludens 1) (TJP1) interaction partners

  1. cyclic strain modulates both the expression and phosphorylation state of occludin (show OCLN Proteins) and ZO-1 in vascular endothelial cells, with putative consequences for endothelial tight junction assembly and barrier integrity

Pig (Porcine) Tight Junction Protein 1 (Zona Occludens 1) (TJP1) interaction partners

  1. ZO-1 and occludin (show OCLN Proteins) are expressed in oocytes and preimplantation embryos, and that ZO-1alpha+ is transcribed by zygotic gene activation and translated from early blastocysts with prominent increase of occludin (show OCLN Proteins) at the blastocyst stage.

TJP1 Protein Profile

Protein Summary

This gene encodes a protein located on a cytoplasmic membrane surface of intercellular tight junctions. The encoded protein may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for this gene.

Gene names and symbols associated with TJP1

  • tight junction protein 1 (TJP1)
  • tight junction protein 1 (Tjp1)
  • tight junction protein 1 (ZO1)
  • tight junction protein 1 (zona occludens 1) (TJP1)
  • zonula occludens 1 (ZO1)
  • ZO-1 protein
  • zo1 protein

Protein level used designations for TJP1

tight junction protein ZO-1 , zona occludens 1 , zona occludens protein 1 , zonula occludens 1 protein , zonula occludens protein 1 , tight junction protein 1 (zona occludens 1) , zonula occludens 1

7082 Homo sapiens
21872 Mus musculus
292994 Rattus norvegicus
100346390 Oryctolagus cuniculus
100718142 Cavia porcellus
407102 Bos taurus
443200 Ovis aries
101082238 Felis catus
403752 Canis lupus familiaris
415388 Gallus gallus
396567 Sus scrofa
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