Tolloid-Like 1 Proteins (TLL1)

TLL1 encodes an astacin-like, zinc-dependent, metalloprotease that belongs to the peptidase M12A family. Additionally we are shipping TLL1 Antibodies (26) and TLL1 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TLL1 21892 Q62381
TLL1 7092 O43897
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Top TLL1 Proteins at

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days

TLL1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
, ,

More Proteins for Tolloid-Like 1 (TLL1) Interaction Partners

Mouse (Murine) Tolloid-Like 1 (TLL1) interaction partners

  1. the proteinases encoded by Bmp1 (show BMP1 Proteins) and Tll1 genes play essential roles in the development and maintenance of mouse dentin and periodontal ligaments.

  2. The presented data demonstrate Bmp1 (show BMP1 Proteins)/Tll1 products to be of profound importance to bone growth and modeling.

  3. TLL1 mRNA levels significantly increased in the tibialis anterior muscle with 3 days of hindlimb suspension and significantly decreased in response to 2 days of food deprivation.

  4. products of Bmp1 (show BMP1 Proteins) and Tll1 are responsible for in vivo cleavage of Chordin (show CHRD Proteins) in mammals

  5. The results show that Nkx2-5 (show NKX2-5 Proteins) is a direct activator of Tll-1 expression and provide insight into the mechanism of the defects found in both the Tll-1 and Nkx2-5 (show NKX2-5 Proteins) knockout mice.

Human Tolloid-Like 1 (TLL1) interaction partners

  1. Multivariate analysis showed rs17047200 AT/TT to be an independent risk factor for HCC (show FAM126A Proteins) (hazard ratio, 1.78; P = .008).

  2. This SNP [TLL1 gene ]could not be confirmed as a risk factor for CHD (show CHDH Proteins) [coronary heart disease]in T2DM [type-2 Diabetes mellitus]patients

  3. This study identified TLL1 as a new susceptibility gene for PTSD.

  4. TLL-1 gene mutation with an insertion mutation of base A in exon 10 is common in Chinese patients with sporadic congenital heart diseases.

  5. We identified a variant in a single PPAR (show PPARA Proteins) pathway gene, TLL1, that is associated with the extent of coronary artery disease independently of clinical predictors, specifically in patients with type 2 diabetes mellitus.

  6. Data demonstrate that TLL-1, which has intermediate activity, forms a calcium-ion dependent dimer with monomers stacked side-by-side.

  7. tolloid-like 1 binds procollagen C-proteinase enhancer protein (show PCOLCE Proteins) 1 and differs from bone morphogenetic protein 1 (show BMP1 Proteins) in the functional roles of homologous protein domains

  8. The crystal structures of the protease domains of human BMP-1 (show BMP1 Proteins) and the closely related Tolloid-like protease 1 (TLL-1), are reported.

  9. Mutations in mammalian tolloid-like 1 gene detected in adult patients with Atrial septal defect

  10. These results indicate that the hypoxia responsive motif is directly involved in the activation of the mTll (show NR2E1 Proteins)-1 transcription under hypoxic conditions.

Zebrafish Tolloid-Like 1 (TLL1) interaction partners

  1. Acts specifically in the ventral tail bud during a approximately 4 h period extending from the completion of gastrulation to early somitogenesis stages to regulate bone morphogenetic protein signaling.

  2. bmp1 (show BMP1 Proteins) and mfn (tll1) gene products functionally overlap and are together responsible for a key portion of the chordin (show CHRD Proteins) processing activity necessary to formation of the zebrafish dorsoventral axis.

Xenopus laevis Tolloid-Like 1 (TLL1) interaction partners

  1. Szl negatively regulates Tll (show NR2E1 Proteins) activity to control deposition of a fibronectin (FN (show FN1 Proteins)) matrix between the mesoderm and endoderm, which is required to maintain BMP signaling

TLL1 Protein Profile

Protein Summary

This gene encodes an astacin-like, zinc-dependent, metalloprotease that belongs to the peptidase M12A family. This protease processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Studies in mice suggest that this gene plays multiple roles in the development of mammalian heart, and is essential for the formation of the interventricular septum. Allelic variants of this gene are associated with atrial septal defect type 6. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Tolloid-Like 1 Proteins (TLL1)

  • tolloid-like (Tll1)
  • tolloid-like 1 (TLL1)
  • tolloid-like 1 (tll1)
  • ASD6 protein
  • tld protein
  • tll protein
  • Tll-1 protein
  • TLL2 protein
  • tolloid protein

Protein level used designations for Tolloid-Like 1 Proteins (TLL1)

mTll , tolloid-like protein 1 , chicken tolloid-like protein 1 , colloid protein , metalloprotease colloid , tolloid-like 2 , dorsal-ventral patterning tolloid-like protein 1 , mfn , mini fin protein , Xolloid-related , xenopus tolloid-like protein 1 , xlr , xolloid-like metalloprotease

21892 Mus musculus
7092 Homo sapiens
395441 Gallus gallus
616468 Bos taurus
101122135 Ovis aries
474335 Danio rerio
399178 Xenopus laevis
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