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TKT encodes a thiamine-dependent enzyme which plays a role in the channeling of excess sugar phosphates to glycolysis in the pentose phosphate pathway. Additionally we are shipping Transketolase Antibodies (43) and Transketolase Kits (11) and many more products for this protein.
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Human TKT Protein expressed in Escherichia coli (E. coli) - ABIN1098225
Choudhary, Kumar, Gnad, Nielsen, Rehman, Walther, Olsen, Mann: Lysine acetylation targets protein complexes and co-regulates major cellular functions. in Science (New York, N.Y.) 2009
transketolase (TKT)is required for cancer growth because of its ability to affect the production of NAPDH to counteract oxidative stress.
Transketolase is upregulated in metastatic peritoneal implants and promotes ovarian cancer cell proliferation.
Akt1 (show AKT1 Proteins) phosphorylates TKT (show DDR2 Proteins) on Thr382, markedly enhancing enzyme activity.
TKT (show DDR2 Proteins) rs3736156 identified significant differences in the onset of cardiovascular event in patients having genotypes AG + AA versus GG
Structure and function of the transketolase from Mycobacterium tuberculosis and comparison with the human enzyme.
Data indicate that transketolase (hTKT). shares 61% sequence identity with transketolase-like protein (TKTL1).
No transketolase activity of TKTDelta38 can be detected for conversion of physiological sugar substrates thus arguing against an intrinsically encoded enzymatic function of TKTL1 in tumor cell metabolism
TKT (show DDR2 Proteins) is a target gene of the BACH1 (show BACH1 Proteins) transcription factor according to ChIP-seq analysis in HEK (show EPHA3 Proteins) 293 cells.
Single Nucleotide Polymorphism in transketolase is associated with diabetic nephropathy.
The crystal structure of human transketolase and new insights into its mode of action.
This gene encodes a thiamine-dependent enzyme which plays a role in the channeling of excess sugar phosphates to glycolysis in the pentose phosphate pathway. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, hypothetical protein
, transketolase-like 2
, transketolase-like protein 2
, transketolase (Wernicke-Korsakoff syndrome)