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TP73 encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. Additionally we are shipping Tumor Protein p73 Antibodies (271) and Tumor Protein p73 Kits (7) and many more products for this protein.
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Data show that the Mdm4 (show MDM4 Proteins)-p73 (show ARHGAP24 Proteins) axis cannot override the dominant role of p53 (show TP53 Proteins) in development and tumorigenesis and that Mdm4 (show MDM4 Proteins) and p73 (show ARHGAP24 Proteins) interaction during development and tumorigenesis suggests new insight into the role of p53 (show TP53 Proteins) family members.
In vivo inhibition of both p63 (show CKAP4 Proteins) and p73 (show ARHGAP24 Proteins) in combination accelerates tumor regression and increases survival of p53 (show TP53 Proteins)-deficient mice.
Results indicate that p73 (show ARHGAP24 Proteins) regulates basal and starvation-induced fuel metabolism in the liver, a finding that is likely to be highly relevant for metabolism-associated disorders, such as diabetes and cancer.
MDM2 (show MDM2 Proteins) mediates p73 (show ARHGAP24 Proteins) ubiquitination
p73 (show ARHGAP24 Proteins) is required for endothelial cell differentiation, migration and the formation of vascular networks regulating VEGF (show VEGFA Proteins) and TGFbeta (show TGFB1 Proteins) signaling
Although mouse TIGAR (show C12orf5 Proteins) expression is clearly induced in the intestines of mice following DNA-damaging stress of ionizing radiation, that was not dependent on p53 (show TP53 Proteins) or TAp73.
Ribosomal proteins L11 (show RPL11 Proteins) and L5 activate TAp73 by overcoming MDM2 (show MDM2 Proteins) inhibition.
the p73 (show ARHGAP24 Proteins) status has to be considered when studying the regulatory role of p53 (show TP53 Proteins) protein in gliomagenesis [review]
Suggest that TAp73 promotes anabolism to counteract cellular senescence rather than to support proliferation.
p63 (show CKAP4 Proteins) antagonizes p53 (show TP53 Proteins) to promote cellular survival, whereas p73 (show ARHGAP24 Proteins) regulates self-renewal and p53 (show TP53 Proteins)-mediated apoptosis versus senescence.
our study demonstrates a novel mechanism of PLK2 (show PLK2 Proteins) in promoting tumor progression, whereby it directly binds to enriched TAp73, catalyzes Ser48 phosphorylation of TAp73, and inhibits TAp73 transcriptional activity
Meta-analysis results suggest that the p73 G4C14-A4T14 polymorphism is associated with an increased risk of cervical squamous cell carcinoma.
Similar to TAp73, DNp73 is stabilized by hypoxia in a HIF-1a-dependent manner, which otherwise is degraded by Siah1.
Data indicate tumor suppressors TP73, RASSF1A (show RASSF1 Proteins), MLH1 (show MLH1 Proteins) and BRCA1 as possible biomarkers to distinguish Pleomorphic invasive lobular cancer (pleomorphic ILC (show CCL27 Proteins)} from classic ILC (show CCL27 Proteins) and infiltrative ductal cancer (IDC (show LMNA Proteins)).
This review establishes the possibility that p73 is indeed capable of both promoting and inhibiting angiogenesis, depending on the cellular context. [review]
Mechanistic investigations indicated that DNp73 acted by attenuating expression of miR (show MLXIP Proteins)-885-5p, a direct regulator of the IGF1 (show IGF1 Proteins) receptor (IGF1R (show IGF1R Proteins)) responsible for stemness marker expression.
Tyrosine-99 phosphorylation determines the regulation of tumor suppressor p73.
MDM2 (show MDM2 Proteins) mediates p73 ubiquitination
Mdm2 (show MDM2 Proteins) overexpression and p73 loss cooperate in genomic instability and tumor development, indicating that the oncogenic function of Mdm2 (show MDM2 Proteins) is a combined effect of inhibiting p53 (show TP53 Proteins) and p73 functions
Authors demonstrate that IGFBP3 (show IGFBP3 Proteins) is a direct TAp73alpha (the p73 isoform that contains the trans-activation domain) target gene and activates the expression of IGFBP3 (show IGFBP3 Proteins) in actively proliferating cells.
This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined.
tumor protein p73
, tumor protein p73-like
, p53-like transcription factor
, p53-related protein
, transformation related protein 73