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TXK Proteins

(TXK tyrosine Kinase (TXK))
Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T- cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskekleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex that acts as a T-helper 1 (Th1) cell- specific transcription factor and binds the promoter of IFNG to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr- 201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor.
TXK Protein (AA 1-527) (His tag) TXK Protein (AA 1-527) (His tag) TXK Protein (AA 1-527) (His tag) (ABIN3134036)

Crystallography grade TXK Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys

TXK Protein (AA 1-527) (His tag) TXK Protein (AA 1-527) (His tag) TXK Protein (AA 1-527) (His tag) (ABIN3096188)

Crystallography grade TXK Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys

TXK Protein (GST tag) (ABIN5509229)

TXK Origin: Rat Host: Insect Cells Recombinant 70 % - 90 % Func Active

TXK Proteins by Grade

Find TXK Proteins with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

TXK Proteins by Origin

Find TXK Proteins for a variety of species such as anti-Human TXK, anti-Mouse TXK, anti-Rat TXK. The species listed below are among those available. Click on a link to go to the corresponding products.

TXK Proteins by Source

Here you will find TXK Proteins proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

TXK Proteins by Protein Type

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TXK Proteins by Application

Find TXK Proteins validated for a specific application such as WB, ELISA, SDS, AP. Some of the available applications are listed below. Click on a link to go to the corresponding products.

TXK Proteins by Biological Activity

Find TXK Proteins with a specific Biological Activity. The Biological Activity listed below are among those available. Click on a link to go to the corresponding products.

Popular TXK Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3134036
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3096188
Quantity 1 mg
Datasheet Datasheet
Reactivity Rat
Source Insect Cells
Validations
Cat. No. ABIN5509229
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
Cat. No. ABIN5509188
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7405181
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1324214
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3012115
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
Cat. No. ABIN1324213
Quantity 25 μg
Datasheet Datasheet

Aliases for TXK Proteins

TXK tyrosine kinase (TXK) Proteins
TXK tyrosine kinase (Txk) Proteins
tyrosine-protein kinase TXK (LOC100544958) Proteins
A130089B16Rik Proteins
BTKL Proteins
Btkl Proteins
PSCTK5 Proteins
PTK4 Proteins
RLK Proteins
Rlk Proteins
TKL Proteins
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