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anti-Tyrosinase  (TYR) Antibodies

The enzyme encoded by TYR catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. Additionally we are shipping Tyrosinase  Kits (61) and Tyrosinase  Proteins (12) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TYR 7299 P14679
TYR 22173 P11344
TYR 308800  
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Top anti-Tyrosinase  Antibodies at antibodies-online.com

Showing 10 out of 201 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, FACS, IF, IHC (p), WB Fow Cytometric analysis of A375 cells using Tyrosinase Antibody (C-term) Cat.-No AP17815PU-N (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Confocal immunofluorescent analysis of Tyrosinase Antibody (C-term) Cat.-No AP17815PU-N with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Dog Rabbit Un-conjugated WB WB Suggested Anti-TYR Antibody Titration: 1.25ug/mlPositive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated IF, IHC (p), WB Western blot analysis of Tyrosinase Antibody (Center) (ABIN391521) in A375, 293 cell line lysates (35 µg/lane). Tyrosinase (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from COS7 cells, treated with UV 30', using Tyrosinase Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Western blot analysis of Tyrosinase antibody (C-term) (ABIN391520) in HepG2 cell line lysates (35 µg/lane). Tyrosinase (arrow) was detected using the purified polyclonal antibody. Tyrosinase Antibody (C-term) (ABIN391520) flow cytometric analysis of A375 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB WB Image Sample (30 ug of whole cell lysate) A: Jurkat B: Raji 7.5% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 8 to 10 Days
$493.17
Details
Cat Mouse Un-conjugated EIA, IF, IHC (p), WB 0.125 mL Log in to see 6 to 8 Days
$500.50
Details
Human Mouse Un-conjugated ICC, IF, IHC (p), ELISA, WB Human Skin (formalin-fixed, paraffin-embedded) stained with TYR antibody ABIN573956 at 10 ug/ml followed by biotinylated anti-mouse IgG secondary antibody ABIN481714, alkaline phosphatase-streptavidin and chromogen. 125 μL Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of Tyrosinase staining in HepG2 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of Tyrosinase staining in human liver formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. AEC was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 9 Days
$487.50
Details

TYR Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Tyrosinase  Antibodies

  1. Human Polyclonal TYR Primary Antibody for EIA, FACS - ABIN453446 : Ostankovitch, Altrich-Vanlith, Robila, Engelhard: N-glycosylation enhances presentation of a MHC class I-restricted epitope from tyrosinase. in Journal of immunology (Baltimore, Md. : 1950) 2009 (PubMed)
    Show all 2 references for ABIN453446

  2. Dog (Canine) Polyclonal TYR Primary Antibody for WB - ABIN2781791 : Bidinost, Hernandez, Edward, Al-Rajhi, Lewis, Lupski, Stockton, Bejjani: Of mice and men: tyrosinase modification of congenital glaucoma in mice but not in humans. in Investigative ophthalmology & visual science 2006 (PubMed)

More Antibodies against Tyrosinase  Interaction Partners

Zebrafish Tyrosinase  (TYR) interaction partners

  1. Retinal pigment epithelium (which normally expresses tyrosinase) secretes a modulatory factor, possibly L-DOPA, which regulates light adaptation in the retinal circuitry.

Atlantic Salmon (Salmo salar) Tyrosinase  (TYR) interaction partners

  1. Transcription of the tyrosinase gene family in an Atlantic salmon leukocyte cell line (SHK (show SHPK Antibodies)-1) is influenced by temperature, but not by virus infection or bacterin stimulation.

Human Tyrosinase  (TYR) interaction partners

  1. Four missense substitutions (p.Arg239Trp, p.Ser192Tyr, p.Ser44Arg and p.Arg77Gln) were identified in tyrosinase in the families with oculocutaneous albinism linkage, and another missense substitution (p.Gln272Lys) was identified in the family with OCA4 linkage

  2. LEF-1 (show LEF1 Antibodies) and MITF (show MITF Antibodies) regulate tyrosinase gene transcription in vitro via binding to its promoter.

  3. Data show that mutant microphthalmia-associated transcription factor (MITF (show MITF Antibodies)) with loss of localization signals (NLS (show ALDH1A2 Antibodies)) has failed to transactivate the transcriptional activities of target gene tyrosinase (TYR), which can cause Waardenburg syndrome.

  4. The tyrosinase gene was examined in 23 unrelated patients with autosomal recessive ocular albinism or nonsyndromic oculocutaneous albinism. TYR gene mutations were identi fi ed in 14 (app (show APP Antibodies). 60%) albinism patients.

  5. The two mutations (c.1114delG in the TYR gene and c.1426A>G in the OCA2 gene) may be responsible for partial clinical manifestations of Oculocutaneous albinism.

  6. Molecular analysis identified two compound heterozygous TYR mutations known to cause OCAIA and cosegregate with oculocutaneous albinism. In addition, we identified a novel heterozygous PAX6 (show PAX6 Antibodies) mutation confirming the atypical aniridia phenotype.

  7. Overall, our data strongly suggest that IRF4 (show IRF4 Antibodies), MC1R (show MSHR Antibodies) and TYR genes likely have pleiotropic effects, a combination of pigmentation and oncogenic functions, resulting in an increased risk of actinic keratosis.

  8. Data indicate that tyrosinase is used as a reporter gene owing to its strong optical absorption and enzymatic amplification mechanism and melamin production.

  9. Identification of four novel TYR mutations in a Chinese Han population with Oculocutaneous albinism 1.

  10. 11/11 individuals with homozygous or compound heterozygous mutations in TYR, have no discernible pigmentation in hair, skin and eyes

Mouse (Murine) Tyrosinase  (TYR) interaction partners

  1. These results suggest that the tyrosinase-induced metabolism of rhodendrol causes melanocyte toxicity.

  2. Data indicate that both ephedrannins A and B were competitive inhibitors of mushroom tyrosinase.

  3. STAP-2 (show STAP2 Antibodies) colocalized with tyrosinase in lysosomes and protected tyrosinase from protein degradation in B16F10 melanoma cells.

  4. Docosahexaenoic acid inhibits melanogenesis in B16F10 cells in vitro through increased tyrosinase degradation.

  5. Studied upregulation by Kaliziri extract of tyrosinase, TRP-1 (show TRPC1 Antibodies), TRP-2 (show DCT Antibodies) and MITF (show MITF Antibodies) expression in murine B16 melanoma cells.

  6. The albino mutation of tyrosinase alters ocular angiogenic responsiveness.

  7. Tyrosinase is mutated in the albino dorsal lateral geniculate nucleus, arising from retinal ganglion cell misspecification together with potential perturbations of early activity patterns in the albino retina.

  8. activated by ascorbic acid in B16 melanoma via p38 MAPK (show MAPK14 Antibodies) signaling and upregulation of melanogenic regulatory factors

  9. Effect of zibuganshenfang on the expression and activity of tyrosinase on B16 cells

  10. the schisis phenotype caused by the Rs1 (show RS1 Antibodies) mutation is rescued by a Tyr mutation in the C57BL/6J genetic background, strongly suggesting that Tyr is the Mor1 (show MDH2 Antibodies) gene.

Tyrosinase  (TYR) Antigen Profile

Protein Summary

The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene.

Gene names and symbols associated with anti-Tyrosinase  (TYR) Antibodies

  • tyrosinase (tyr) antibody
  • hypothetical protein (tyrosinase) antibody
  • tyrosinase (oculocutaneous albinism IA) (tyr) antibody
  • tyrosinase (oculocutaneous albinism IA) (TYR) antibody
  • tyrosinase (Celal_3121) antibody
  • tyrosinase (Halhy_4121) antibody
  • tyrosinase (Mesop_2736) antibody
  • tyrosinase (LOC100136546) antibody
  • tyrosinase (TYR) antibody
  • tyrosinase (Tyr) antibody
  • albino antibody
  • C antibody
  • CMM8 antibody
  • LOC100136546 antibody
  • OCA1A antibody
  • OCAIA antibody
  • sandy antibody
  • SHEP3 antibody
  • skc35 antibody
  • tyr antibody
  • TYRO antibody
  • zgc:109705 antibody

Protein level used designations for anti-Tyrosinase  (TYR) Antibodies

oca1 , sdy , tyra , hypothetical protein , tyrosinase (oculocutaneous albinism IA) , tyrosinase , monophenol monooxygenase , tyrosinase-like , LB24-AB , SK29-AB , oculocutaneous albinism IA , tumor rejection antigen AB , albino locus protein

GENE ID SPECIES
30207 Danio rerio
189907 Caenorhabditis elegans
398715 Xenopus laevis
451473 Pan troglodytes
705792 Macaca mulatta
10145547 Cellulophaga algicola DSM 14237
10588308 Haliscomenobacter hydrossis DSM 1100
10826573 Mesorhizobium opportunistum WSM2075
100049427 Oryzias latipes
100125152 Xenopus (Silurana) tropicalis
100135825 Oncorhynchus mykiss
100136546 Salmo salar
100453479 Pongo abelii
100594055 Nomascus leucogenys
7299 Homo sapiens
22173 Mus musculus
308800 Rattus norvegicus
100713552 Cavia porcellus
403405 Canis lupus familiaris
751100 Felis catus
100008753 Oryctolagus cuniculus
407745 Sus scrofa
280951 Bos taurus
373971 Gallus gallus
780502 Ovis aries
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