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UL16 Binding Protein 2 Proteins (ULBP2)

Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. Additionally we are shipping ULBP2 Antibodies (38) and ULBP2 Kits (20) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ULBP2 80328 Q9BZM5
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Top ULBP2 Proteins at

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human Fc Tag 100 μg Log in to see 16 Days
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 2 to 3 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 Days
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
HOST_Mammalian Cells Human His tag   50 μg Log in to see 5 Days
HOST_Human Human His tag   10 μg Log in to see 11 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 11 Days
HOST_Human Human Un-conjugated   10 μg Log in to see 11 to 14 Days

ULBP2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, ,

Top referenced ULBP2 Proteins

  1. Human ULBP2 Protein expressed in Escherichia coli (E. coli) - ABIN1098658 : Dunn, Chalupny, Sutherland, Dosch, Sivakumar, Johnson, Cosman: Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity. in The Journal of experimental medicine 2003 (PubMed)
    Show all 2 references for ABIN1098658

  2. Human ULBP2 Protein expressed in Human Cells - ABIN2005067 : Cosman, Müllberg, Sutherland, Chin, Armitage, Fanslow, Kubin, Chalupny: ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. in Immunity 2001 (PubMed)
    Show all 2 references for ABIN2005067

More Proteins for UL16 Binding Protein 2 (ULBP2) Interaction Partners

Human UL16 Binding Protein 2 (ULBP2) interaction partners

  1. IMP3 (show IGF2BP3 Proteins) directly interacts with ULBP2 mRNA, leading to ULBP2 transcript destabilization and reduced ULBP2 surface expression and indirectly downregulates MICB (show MICB Proteins) with a mechanism functionally distinct from that of ULBP2.

  2. By suppressing AR and up-regulating ULBP2 in HCC (show FAM126A Proteins), cisplatin could up-regulate cytotoxicity of NK cells to better target HCC (show FAM126A Proteins).

  3. human tumor cells lost their surface expression of ULBP2, but not ULBP1 and ULBP3, during NK cell-mediated cytolysis.

  4. This study suggests that NKG2D (show KLRK1 Proteins) ligands shedding of MICA (show MICA Proteins), MICB (show MICB Proteins) and ULBP-2 is a novel pathway in endometriosis complex pathogenesis that impairs Natural Killer Cells cell function.

  5. Varicella-Zoster Virus differentially modulates expression of the NKG2D ligands by upregulating MICA expression and reducing ULBP2 and ULBP3 expression in the infected cells.

  6. A conserved WW domain-like motif regulates CD74 (show CD74 Proteins) antigen-dependent cell-surface transport of the NKG2D (show KLRK1 Proteins) ligand ULBP2.

  7. NKG2D (show KLRK1 Proteins) and NKG2DL are involved in allergen-induced activation of dendritic epidermal T cells and the NKG2D (show KLRK1 Proteins)/NKG2DL pathway might be a potential target for treatment of contact hypersensitivity.

  8. Human anaplastic thyroid carcinoma cells are sensitive to NK cell-mediated lysis via ULBP2/5/6 and chemoattract NK cells.

  9. Data inticate that heat shock protein 60 (HSP60 (show HSPD1 Proteins)) interacted constitutively with NKG2D (show KLRK1 Proteins) ligand ULBP2 and phosphatase of regenerating liver 3 (PRL-3) regulated HSP60 (show HSPD1 Proteins) tyrosine phosphorylation.

  10. Results suggest that ULBP2 is expressed and released from cervical cancer cells by CRF (show CRH Proteins), which regulates NKG2D (show KLRK1 Proteins) expression in natural killer cells.

ULBP2 Protein Profile

Protein Summary

Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis- Golgi apparatus so that it does not reach the cell surface.

Gene names and symbols associated with UL16 Binding Protein 2 Proteins (ULBP2)

  • UL16 binding protein 2 (ULBP2)
  • UL16 binding protein 2-like (LOC100355436)
  • N2DL2 protein
  • RAET1H protein

Protein level used designations for UL16 Binding Protein 2 Proteins (ULBP2)

ALCAN-alpha , N2DL-2 , NKG2D ligand 2 , NKG2DL2 , UL16-binding protein 2 , retinoic acid early transcript 1 H , retinoic acid early transcript 1H

80328 Homo sapiens
100355436 Oryctolagus cuniculus
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