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WAP Four-Disulfide Core Domain 2 Proteins (WFDC2)

WFDC2 encodes a protein that is a member of the WFDC domain family. Additionally we are shipping WFDC2 Antibodies (154) and WFDC2 Kits (18) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
WFDC2 10406 Q14508
WFDC2 67701 Q9DAU7
Rat WFDC2 WFDC2 286888 Q8CHN3
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Top WFDC2 Proteins at

Showing 10 out of 29 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human GST tag WAP Four-Disulfide Core Domain 2 (WFDC2) (AA 31-124), (full length) protein (GST tag) 50 μg Log in to see 9 to 11 Days
HOST_HEK-293 Cells Human His tag Human HE4, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 100 μg Log in to see 2 to 3 Days
HOST_Human Cells Human His tag 100 μg Log in to see 20 to 21 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
HOST_Human Cells Mouse His tag 50 μg Log in to see 20 to 21 Days
HOST_Mammalian Cells Human His tag   50 μg Log in to see 5 Days
HOST_Wheat germ Human GST tag   10 μg Log in to see 9 Days
HOST_Human Human His tag   10 μg Log in to see 11 Days
HOST_Human Cells Dog Fc Tag 100 μg Log in to see 20 to 21 Days
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days

WFDC2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , , , ,
, ,
Mouse (Murine)

Top referenced WFDC2 Proteins

  1. Human WFDC2 Protein expressed in Escherichia coli (E. coli) - ABIN1047932 : Kirchhoff, Habben, Ivell, Krull: A major human epididymis-specific cDNA encodes a protein with sequence homology to extracellular proteinase inhibitors. in Biology of reproduction 1992 (PubMed)
    Show all 2 references for ABIN1047932

  2. Human WFDC2 Protein expressed in Wheat germ - ABIN1325310 : Eaton, Shallcross, Mael, Mears, Minkoff, Scoville, Whelan: Selection of DNA aptamers for ovarian cancer biomarker HE4 using CE-SELEX and high-throughput sequencing. in Analytical and bioanalytical chemistry 2015 (PubMed)

  3. Human WFDC2 Protein expressed in Human Cells - ABIN2005283 : LeBleu, Teng, OConnell, Charytan, Müller, Müller, Sugimoto, Kalluri: Identification of human epididymis protein-4 as a fibroblast-derived mediator of fibrosis. in Nature medicine 2013 (PubMed)

  4. Human WFDC2 Protein expressed in HEK-293 Cells - ABIN2181198 : Hellström, Raycraft, Hayden-Ledbetter, Ledbetter, Schummer, McIntosh, Drescher, Urban, Hellström: The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma. in Cancer research 2003 (PubMed)

More Proteins for WAP Four-Disulfide Core Domain 2 (WFDC2) Interaction Partners

Human WAP Four-Disulfide Core Domain 2 (WFDC2) interaction partners

  1. This study found that increased serum HE4 is independently associated with the development of Lupus Nephritis and Chronic Kidney Disease in Systemic Lupus Erythematosus patients.

  2. The present study displayed the most fundamental and full-scale data to show differentially expressed genes in response to HE4

  3. We found the high specificity of HE4 and CA125 (show MUC16 Proteins) while differentiating ovarian benign diseases from epithelial ovarian cancer in postmenopausal women and the high sensitivity of CA125 (show MUC16 Proteins) in detecting epithelial ovarian cancer in premenopausal patients

  4. HE4 levels at primary diagnosis correlate with an increased risk of endometrial cancer recurrence, particularly in cases of endometrioid histotype, and they may help to recognize patients who may need a more intensive follow-up

  5. Overexpression of HE4 promotes collateral resistance to cisplatin and paclitaxel, and downregulation of HE4 partially reverses this chemoresistance.

  6. High Serum HE4 level is associated with epithelial ovarian cancer.

  7. HE4 and miR (show MLXIP Proteins)-21 may play an important role in the development and progression of ovarian cancer and they may serve as prognostic indicators in ovarian cancer

  8. HE4 had more potential than CA125 (show MUC16 Proteins).

  9. High serum HE-4 levels were associated with Endometrial Cancer.

  10. High HE4 expression is associated with Ovarian Tumors.

Mouse (Murine) WAP Four-Disulfide Core Domain 2 (WFDC2) interaction partners

  1. Causal testing implicates Wfdc2 and Hdac3 (show HDAC3 Proteins) as novel genes affecting high density lipoprotein levels

WFDC2 Protein Profile

Protein Summary

This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation.

Gene names and symbols associated with WFDC2

  • WAP four-disulfide core domain 2 (WFDC2)
  • WAP four-disulfide core domain 2 (wfdc2)
  • Epididymal secretory protein E4 (E4)
  • WAP four-disulfide core domain 2 (Wfdc2)
  • 1600023A02Rik protein
  • BE-20 protein
  • CE4 protein
  • dJ461P17.6 protein
  • EDDM4 protein
  • HE4 protein
  • re4 protein
  • si:ch211-153a8.3 protein
  • WAP5 protein
  • WFDC2 protein
  • WFDC3 protein

Protein level used designations for WFDC2

WAP four-disulfide core domain 2 , WAP four-disulfide core domain 3 , WAP four-disulfide core domain protein 2 , WAP domain containing protein HE4-V4 , epididymal protein 4 , epididymal secretory protein E4 , epididymis-specific, whey-acidic protein type, four-disulfide core , major epididymis-specific protein E4 , putative protease inhibitor WAP5 , WAP domain-containing protein HE4 , epididymal secretory protein 4 , epididymal protein BE-20

419300 Gallus gallus
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618044 Bos taurus
100074492 Ornithorhynchus anatinus
556600 Danio rerio
396987 Sus scrofa
10406 Homo sapiens
67701 Mus musculus
286888 Rattus norvegicus
403919 Canis lupus familiaris
100009206 Oryctolagus cuniculus
Selected quality suppliers for WFDC2 Proteins (WFDC2)
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