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WFDC2 encodes a protein that is a member of the WFDC domain family. Additionally we are shipping WFDC2 Antibodies (155) and WFDC2 Kits (21) and many more products for this protein.
Showing 10 out of 31 products:
Human WFDC2 Protein expressed in Human Cells - ABIN2005283
LeBleu, Teng, OConnell, Charytan, Müller, Müller, Sugimoto, Kalluri: Identification of human epididymis protein-4 as a fibroblast-derived mediator of fibrosis. in Nature medicine 2013
Human WFDC2 Protein expressed in Wheat germ - ABIN1325310
Eaton, Shallcross, Mael, Mears, Minkoff, Scoville, Whelan: Selection of DNA aptamers for ovarian cancer biomarker HE4 using CE-SELEX and high-throughput sequencing. in Analytical and bioanalytical chemistry 2015
This review summarizes data regarding the detection and alteration of HE4 in urine samples collected from ovarian cancer patients and controls.
HE4 is a prognostic marker in endometrial cancer
HE4 levels correspond to clinical and FIGO stage of endometrial cancer
HE4 is elevated less frequently than CA125 (show MUC16 Proteins) in benign adnexal tumors, regardless of age or menopausal status
HE4 expression in biopsy material from endometrial hyperplasia can be monitored and regulated by progestin. Changes in the expression of HE4 during progestin therapy regimens can predict therapy response or indicate progestin resistance for medium- and low-risk endometrial hyperplasia.
Serum HE4 levels were significantly elevated in children and adults with cystic fibrosis (show S100A8 Proteins) (CF) compared to controls. Abnormal but lower HE4 concentrations were found in cases of severe bronchitis, asthma, pneumonia, and bronchiectasis. HE4 mRNA levels were significantly upregulated in CF vs. non-CF airway biopsy specimens.
Human epididymis protein 4 induces chemoresistance against anti-cancer drugs and activates the AKT (show AKT1 Proteins) and Erk (show EPHB2 Proteins) pathways to enhance tumor survival. Human epididymis protein 4 expression in ovarian cancer tissue is associated with a worse prognosis for epithelial ovarian cancer patients.
This study found that increased serum HE4 is independently associated with the development of Lupus Nephritis and Chronic Kidney Disease in Systemic Lupus Erythematosus patients.
The present study displayed the most fundamental and full-scale data to show differentially expressed genes in response to HE4
We found the high specificity of HE4 and CA125 (show MUC16 Proteins) while differentiating ovarian benign diseases from epithelial ovarian cancer in postmenopausal women and the high sensitivity of CA125 (show MUC16 Proteins) in detecting epithelial ovarian cancer in premenopausal patients
Causal testing implicates Wfdc2 and Hdac3 (show HDAC3 Proteins) as novel genes affecting high density lipoprotein levels
This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation.
WAP four-disulfide core domain 2
, WAP four-disulfide core domain 3
, WAP four-disulfide core domain protein 2
, WAP domain containing protein HE4-V4
, epididymal protein 4
, epididymal secretory protein E4
, epididymis-specific, whey-acidic protein type, four-disulfide core
, major epididymis-specific protein E4
, putative protease inhibitor WAP5
, WAP domain-containing protein HE4
, epididymal secretory protein 4
, epididymal protein BE-20