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anti-phosphodiesterase 10A (PDE10A) Antibodies

The protein encoded by PDE10A belongs to the cyclic nucleotide phosphodiesterase family. Additionally we are shipping PDE10A Kits (8) and PDE10A Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PDE10A 10846 Q9Y233
PDE10A 23984 Q8CA95
PDE10A 63885 Q9QYJ6
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Top anti-PDE10A Antibodies at

Showing 10 out of 36 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, IHC (p), IP, WB Western Blot of PD10A-101AP (1:500) using CNS Blot. 1. Frontal Cortex 2. Pariental Cortex 3. Striatum 4. Amygdela 5. Hypothalamus 6. Hippocampus 7. Olfactory bulb 8. Brain Stem 9. Cerebellum 10. Spinal cord and 11. Whole Brain Immunohistochemistry-Paraffin: PDE10A Antibody [ABIN152798] - Slide A is negative control. Slide B is stained with ABIN152798 at 1:200 antibody dilution in DiluObuffer. 0.1 mg Log in to see 5 to 7 Days
Human Rabbit Un-conjugated IP, WB 0.1 mg Log in to see 6 to 8 Days
Human Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 2 to 3 Days
Human Mouse Un-conjugated FACS, WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PDE10A (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-PDE10A. 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 14 Days
Rat Rabbit Un-conjugated WB   0.1 mg Log in to see 6 to 8 Days
Human Rabbit Un-conjugated WB   0.1 mg Log in to see 6 to 8 Days
Human Mouse Un-conjugated IHC, WB Immunohistochemical staining of paraffin-embedded Adenocarcinoma of breast tissue using anti-PDE10A mouse monoclonal antibody. (ABIN2452520, Dilution 1:50) Immunohistochemical staining of paraffin-embedded colon tissue using anti-PDE10A mouse monoclonal antibody. (ABIN2452520, Dilution 1:50) 100 μL Log in to see 2 to 3 Days
Human Mouse Un-conjugated FACS, WB 100 μL Log in to see 8 to 10 Days
Human Mouse Un-conjugated IHC (p), WB 100 μL Log in to see 8 to 10 Days

PDE10A Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , ,

Mouse (Murine)


Rat (Rattus)


Top referenced anti-PDE10A Antibodies

  1. Human Polyclonal PDE10A Primary Antibody for WB - ABIN493330 : Kotera, Fujishige, Yuasa, Omori: Characterization and phosphorylation of PDE10A2, a novel alternative splice variant of human phosphodiesterase that hydrolyzes cAMP and cGMP. in Biochemical and biophysical research communications 1999 (PubMed)
    Show all 3 references for ABIN493330

  2. Rat (Rattus) Polyclonal PDE10A Primary Antibody for WB - ABIN493332 : Fujishige, Kotera, Omori: Striatum- and testis-specific phosphodiesterase PDE10A isolation and characterization of a rat PDE10A. in European journal of biochemistry / FEBS 2000 (PubMed)
    Show all 3 references for ABIN493332

  3. Human Polyclonal PDE10A Primary Antibody for ELISA, ICC - ABIN152798 : Li, Lee, Xi, Zhu, Gary, Ramírez-Alcántara, Gurpinar, Canzoneri, Fajardo, Sigler, Piazza, Chen, Andrews, Thomas, Lu, Li, Laan, Moyer, Russo, Eberhardt, Yet, Keeton, Grizzle, Piazza: Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity. in Oncogene 2015 (PubMed)
    Show all 2 references for ABIN152798

  4. Human Polyclonal PDE10A Primary Antibody for ELISA, WB - ABIN1451106 : Loughney, Snyder, Uher, Rosman, Ferguson, Florio: Isolation and characterization of PDE10A, a novel human 3', 5'-cyclic nucleotide phosphodiesterase. in Gene 1999 (PubMed)

More Antibodies against PDE10A Interaction Partners

Human phosphodiesterase 10A (PDE10A) interaction partners

  1. Studied what regions of the PDE10A gene are transcribed in human putamen and caudate nucleus brain tissue, two sub-regions of the striatum. Surprisingly, twelve novel transcripts were detected, of which three were predicted to be translated into PDE10A proteins with unique N-termini.studies show that there is much more transcript diversity within the PDE10A gene region than initially believed.

  2. The PDE10A gene is currently known to be comprised of 23 exons26 and maps to chromosome 6q26,17, 18 a region previously associated with bipolar disorder.

  3. germline PDE10A mutations associated with hyperkinetic movement disorder

  4. We have demonstrated that de novo dominant mutations in PDE10A are the cause of a unique movement disorder characterized by benign childhood-onset chorea and typical MRI (show C7ORF49 Antibodies) abnormalities of the striatum.

  5. cGMP PDE (show ALDH7A1 Antibodies) isozymes, PDE5 (show PDE5A Antibodies) and 10, are elevated in colon tumor cells compared with normal colonocytes, and inhibitors and siRNAs can selectively suppress colon tumor cell growth

  6. Longitudinal data in a cohort of patients with early Huntington disease (show HTT Antibodies) found PDE10 to be a useful biomarker of disease progression.

  7. Lu AF33241 represents a novel PDE2A (show PDE2A Antibodies)/PDE10A inhibitor tool which can penetrate the blood brain barrier.

  8. PDE10A activity in medium spiny neurons in Huntington's disease might still be high in critical subcellular compartments, despite the overall striatal PDE10A decrease measured using positron-emission tomography.

  9. HPRT (show HPRT1 Antibodies)-deficiency alters cAMP/PKA signaling pathway, which is in part due to the increased of PDE10A expression and activi

  10. The present study is the first to demonstrate a central role of PDE10A in progressive pulmonary vascular remodeling.

Mouse (Murine) phosphodiesterase 10A (PDE10A) interaction partners

  1. Through a combination of pharmacological and genetic tools, study provides convergent evidence of D2 (rather than D1) pathway dominant effects of PDE10A inhibition in rodents

  2. A knock-in mouse model carrying the homologous p.Tyr97Cys variant had decreased striatal PDE10A and also displayed motor abnormalities

  3. Its alteration leads to a cause of Huntington disease (show HTT Antibodies).

  4. data show that PDE10A plays a pivotal role in striatal signaling and striatum-mediated salience attribution

  5. findings reveal a dynamic interplay between PDE10A activity, level of neuronal network depolarization and degree of dopaminergic tone in the ability of D1 receptors to facilitate the GABAergic transmission to SNpr neurons.

  6. PDE10A deficiency produces a decrease in caloric intake without affecting meal frequency, daytime versus nighttime feeding behavior, or locomotor activity.

  7. PDE10A-deficient mice showed changes in appetitively as well as aversively motivated responding, and in visuospatial learning and memory, which could not be reduced to neuromotor impairments.

  8. Observed suppression of PDE10A activity significantly inhibits gene expression in the striatum and predicts neuroprotective effects in models of Huntington's disease.

  9. findings suggest that PDE10A is involved in regulating striatal output, possibly by reducing the sensitivity of medium spiny neurons to glutamatergic excitation

  10. PDE10A knockout mice showed a significant change in striatal dopamine turnover, which was accompanied by an enhanced locomotor response to amphetamine

PDE10A Antigen Profile

Protein Summary

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene.

Gene names and symbols associated with PDE10A

  • phosphodiesterase 10A (PDE10A) antibody
  • phosphodiesterase 10A (Pde10a) antibody
  • HSPDE10A antibody
  • Pde10a3 antibody

Protein level used designations for PDE10A

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A , dJ416F21.1 (phosphodiesterase 10A) , phosphodiesterase 10A1 (PDE10A1) , PDE10A2 brain-specific isoform , dual-substrate cAMP and cGMP, cyclic nucleotide phosphodiesterase , testis-specific phosphodiesterase PDE10A2

10846 Homo sapiens
23984 Mus musculus
63885 Rattus norvegicus
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