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ARHGAP31 encodes a GTPase-activating protein (GAP). Additionally we are shipping and many more products for this protein.
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a four-generation pedigree with isolated terminal limb defects and a truncating mutation in ARHGAP31 underscores the relevance of sequencing ARHGAP31 in cases of isolated limb defects, irrespective of presence of a complete Adams-Oliver syndrome phenotype
The focal adhesion-localized CdGAP regulates matrix rigidity sensing and durotaxis.
Data demonstrate that cdGAP negatively regulates directed and random migration by controlling adhesion maturation and dynamics through the regulation of both adhesion assembly and disassembly.
specific interaction between negatively charged phospholipid PI(3,4,5)P3 and the stretch of polybasic residues preceding the RhoGAP (show ARHGAP1 Antibodies) domain regulates CdGAP activity in vivo and is required for its cellular functions.
Rho GTPase activating protein 31
Our findings demonstrate that heterozygous gain-of-function mutations in ARHGAP31 cause an autosomal-dominant form of ACC-TTLD through introduction of premature termination codons in the terminal exon of the gene.
Results suggest that CdGAP may play an unexpected role in apoptosis.
CdGAP is a novel glycogen synthase kinase 3alpha (GSK-3alpha) substrate.
Increased levels of endogenous CdGAP in mammary tumor explant cells resulted in increased cell motility and invasion in response to TGF-beta (show TGFB1 Antibodies), and downregulation by siRNA inhibited cell motility and invasion. CdGAP is required for TGF-beta (show TGFB1 Antibodies) effects.
Data show that intersectin-SH3D interacts directly with a small region of CdGAP highly enriched in basic residues and comprising a novel conserved xKx(K/R)K motif.
CdGAP is a novel substrate of extracellular signal-regulated kinase (ERK)1/2 and mediates cross talk between the Ras/mitogen-activated protein kinase pathway and regulation of Rac1 activity.
Nudel (show NDEL1 Antibodies) facilitates cell migration by sequestering Cdc42GAP (show ARHGAP1 Antibodies) at the leading edge to stabilize active Cdc42 (show CDC42 Antibodies) in response to extracellular stimuli.
This gene encodes a GTPase-activating protein (GAP). A variety of cellular processes are regulated by Rho GTPases which cycle between an inactive form bound to GDP and an active form bound to GTP. This cycling between inactive and active forms is regulated by guanine nucleotide exchange factors and GAPs. The encoded protein is a GAP shown to regulate two GTPases involved in protein trafficking and cell growth.
Cdc42 GTPase-activating protein
, rho GTPase-activating protein 31
, CDC42 GTPase-activating protein