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Browse our anti-Glycerol-3-Phosphate Acyltransferase, Mitochondrial (GPAM) Antibodies

Full name:
anti-Glycerol-3-Phosphate Acyltransferase, Mitochondrial Antibodies (GPAM)
On www.antibodies-online.com are 64 Glycerol-3-Phosphate Acyltransferase, Mitochondrial (GPAM) Antibodies from 17 different suppliers available. Additionally we are shipping Glycerol-3-Phosphate Acyltransferase, Mitochondrial Kits (7) and Glycerol-3-Phosphate Acyltransferase, Mitochondrial Proteins (5) and many more products for this protein. A total of 80 Glycerol-3-Phosphate Acyltransferase, Mitochondrial products are currently listed.
Synonyms:
Gpam, GPAT, GPAT1

Most Popular Reactivities for anti-Glycerol-3-Phosphate Acyltransferase, Mitochondrial (GPAM) Antibodies

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anti-Mouse (Murine) Antibodies:

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anti-Rat (Rattus) Antibodies:

All available anti-Glycerol-3-Phosphate Acyltransferase, Mitochondrial Antibodies

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Top referenced anti-Glycerol-3-Phosphate Acyltransferase, Mitochondrial Antibodies

  1. Human Polyclonal GPAM Primary Antibody for EIA, WB - ABIN952583 : Reiling, van Vliet-Ostaptchouk, van t Riet, van Haeften, Arp, Hansen, Kremer, Groenewoud, van Hove, Romijn, Smit, Nijpels, Heine, Uitterlinden, Pedersen, Slagboom, Maassen, Hofker, t Hart, Dekker: Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study. in European journal of human genetics : EJHG 2009 (PubMed)
    Show all 3 references for ABIN952583

  2. Human Polyclonal GPAM Primary Antibody for ELISA, WB - ABIN566151 : Li, Sugiyama, Yokoyama, Jiang, Tanaka, Aoyama: Molecular mechanism of age-specific hepatic lipid accumulation in PPARalpha (+/-):LDLR (+/-) mice, an obese mouse model. in Lipids 2008 (PubMed)
    Show all 2 references for ABIN566151

  3. Human Polyclonal GPAM Primary Antibody for EIA, IHC (p) - ABIN499910 : Coleman, Lee: Enzymes of triacylglycerol synthesis and their regulation. in Progress in lipid research 2003 (PubMed)

More Antibodies against Glycerol-3-Phosphate Acyltransferase, Mitochondrial Interaction Partners

Mouse (Murine) Glycerol-3-Phosphate Acyltransferase, Mitochondrial (GPAM) interaction partners

  1. Silencing of GPAT1 by gpat1 siRNA transfection reduced glucosamine-mediated anti-apoptosis in mouse embryonic stem cells and reduced mammalian target of rapamycin (show FRAP1 Antibodies) phosphorylation.

  2. GPAT1, but not GPAT4 (show AGPAT6 Antibodies), is required to incorporate de novo synthesized fatty acids into TAG and to divert them away from oxidation.

  3. GPAT1 deletion is capable of reducing the number of new T cells produced via alterations in membrane receptor function.

  4. In the neonatal liver, DNA methylation (show HELLS Antibodies) of the Gpam promoter inhibited recruitment of the lipogenic transcription factor SREBP-1c (show SREBF1 Antibodies), whereas in the adult, decreased DNA methylation (show HELLS Antibodies) resulted in active chromatin conformation, allowing recruitment of SREBP-1c (show SREBF1 Antibodies).

  5. It was hypothesized that GPAT isoform GPAT1 might influence liver susceptibility to tumorigenesis. Data show that alterations in the formation of complex lipids catalyzed by Gpat1 reduce susceptibility to DEN-induced liver tumorigenesis.

  6. Sterol regulatory element binding protein 1 mediated induction of hepatic steatosis in obese mice requires Gpat1.

  7. Data confirm the role of mitochondrial glycerol-3-phosphate acyltransferase (GPAT) in the synthesis of triacylglycerol, in the fatty acid content of triacylglycerol and cholesterol esters, and in the positioning of specific fatty acids in phospholipids.

  8. mtGPAT1 is essential for normal acyl-CoA (show GNPAT Antibodies) metabolism, and that the absence of hepatic mtGPAT1 results in the partitioning of fatty acids away from triacylglycerol synthesis and toward oxidation and ketogenesis

  9. Increased hepatic mtGPAT activity associated with obesity and insulin (show INS Antibodies) resistance MAY contribute to increased TAG biosynthesis and inhibition of fatty acid oxidation, responses that would promote hepatic steatosis and dyslipidemia.

  10. Gpat1-/- liver exhibits increased oxidative stress and sensitivity of the mitochondrial permeability transition pore, and a balanced increase in apoptosis and proliferation.

Human Glycerol-3-Phosphate Acyltransferase, Mitochondrial (GPAM) interaction partners

  1. two transcriptional initiation sites and two promoters (promoter I and II) required for expression of the human GPAT1 (hGPAT1) gene were identified.

  2. Results suggest that GPAM is expressed in human breast cancer with associated changes in the cellular metabolism, in particular an increased synthesis of phospholipids, the major structural component of cellular membranes.

Cow (Bovine) Glycerol-3-Phosphate Acyltransferase, Mitochondrial (GPAM) interaction partners

  1. Result showed that the knockdown of GPAM expression significantly reduced the synthesis of triglycerides and expression of lipid metabolism-related gene in bovine embryonic fibroblast cells (p<0.05), and the over-expression of GPAM could significantly increased the levels of triglyceride and expression of lipid metabolism-related gene (p<0.05).

  2. Expression pattern differs with those of non-ruminant animals where liver is one of the tissues with higher mRNA expression level. (Glycerol-3-phosphate acyltransferase mitochondrial)

Glycerol-3-Phosphate Acyltransferase, Mitochondrial (GPAM) Antigen Profile

Antigen Summary

This gene encodes a mitochondrial enzyme which prefers saturated fatty acids as its substrate for the synthesis of glycerolipids. This metabolic pathway's first step is catalyzed by the encoded enzyme. Two forms for this enzyme exist, one in the mitochondria and one in the endoplasmic reticulum. Two alternatively spliced transcript variants have been described for this gene.

Alternative names and synonyms associated with Glycerol-3-Phosphate Acyltransferase, Mitochondrial (GPAM)

  • glycerol-3-phosphate acyltransferase, mitochondrial (GPAM) antibody
  • glycerol-3-phosphate acyltransferase, mitochondrial (gpam) antibody
  • glycerol-3-phosphate acyltransferase (GPAT) antibody
  • glycerol-3-phosphate acyltransferase, mitochondrial (Gpam) antibody
  • Gpam antibody
  • GPAT antibody
  • GPAT1 antibody

Protein level used designations for GPAM

mitochondrial glycerol 3-phosphate acyltransferase , glycerol-3-phosphate acyltransferase, mitochondrial , GPAT-1 , P90 , glycerol-3-phosphate acyltransferase 1, mitochondrial , glycerol 3-phosphate acyltransferase, mitochondrial , GPAT , mitochondrial glycerol phosphate acyltransferase

GENE ID SPECIES
100068677 Equus caballus
450738 Pan troglodytes
100561896 Anolis carolinensis
397629 Sus scrofa
14732 Mus musculus
57678 Homo sapiens
29653 Rattus norvegicus
423895 Gallus gallus
486890 Canis lupus familiaris
497202 Bos taurus
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