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GPAM antibody (C-Term)

GPAM Reactivity: Human, Rat, Mouse WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN499910
  • Target See all GPAM Antibodies
    GPAM (Glycerol-3-Phosphate Acyltransferase, Mitochondrial (GPAM))
    Binding Specificity
    • 15
    • 7
    • 7
    • 6
    • 6
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 45
    • 17
    • 2
    • 1
    Human, Rat, Mouse
    Host
    • 41
    • 4
    Rabbit
    Clonality
    • 44
    • 1
    Polyclonal
    Conjugate
    • 17
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GPAM antibody is un-conjugated
    Application
    • 41
    • 22
    • 13
    • 13
    • 12
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    This antibody reacts to GPAT1.
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    GPAT1 antibody was raised against a 15 amino acid peptide near the carboxy terminus of the human GPAT1.
    Isotype
    IgG
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  • Application Notes
    ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C.
  • Target
    GPAM (Glycerol-3-Phosphate Acyltransferase, Mitochondrial (GPAM))
    Alternative Name
    GPAM / GPAT1 (GPAM Products)
    Synonyms
    Gpam antibody, GPAT antibody, GPAT1 antibody, glycerol-3-phosphate acyltransferase, mitochondrial antibody, GPAM antibody, gpam antibody, Gpam antibody
    Background
    Glycerol-3-phosphate acyltransferase 1 (GPAT1), one of four known GPAT isoforms, is located on the mitochondrial outer membrane, allowing reciprocal regulation with carnitine palmitoyltransferase-1. It is thought to be critical for the development of hepatic steatosis, steatosis triggered by GPAT1 overexpression leads to hepatic and possibly peripheral insulin resistance. GPAT1 is transcriptionally upregulated by insulin and sterol regulatory element binding protein (SREBP-1) and downregulated by AMP-activated protein kinase. Mice deficient in GPAT1 exhibit decreased triacylglycerol (TAG) in cardiomyocytes even in high-fat diets, suggesting that GPAT1 contributes significantly to TAG accumulation in heart tissue during lipogenic or high fat diets. At least two isoforms of GPAT1 are known to exist.Synonyms: Glycerol-3-phosphate acyltransferase 1, KIAA1560
    Gene ID
    57678
    NCBI Accession
    NP_065969
    UniProt
    Q9HCL2
    Pathways
    Activated T Cell Proliferation
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