Browse our anti-PYCARD (PYCARD) Antibodies

Full name:
anti-PYD and CARD Domain Containing Antibodies (PYCARD)
On are 154 PYD and CARD Domain Containing (PYCARD) Antibodies from 19 different suppliers available. Additionally we are shipping PYCARD Proteins (8) and PYCARD Kits (6) and many more products for this protein. A total of 180 PYCARD products are currently listed.
9130417A21Rik, Asc, asc1, CARD5, masc, TMS, TMS-1, TMS1, TNS1, zAsc, zgc:109874
list all antibodies Gene Name GeneID UniProt
PYCARD 282817  

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Top referenced anti-PYCARD Antibodies

  1. Human Monoclonal PYCARD Primary Antibody for IP, WB - ABIN1105662 : Norlén, Curry, Björkqvist, Maule, Cunningham, Hogg, Harriott, Johnston, Hutton, Håkanson: Cell-specific processing of chromogranin A in endocrine cells of the rat stomach. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2001 (PubMed)
    Show all 8 references for 1105662

  2. Human Polyclonal PYCARD Primary Antibody for WB - ABIN610691 : Auphan, DiDonato, Rosette, Helmberg, Karin: Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. in Science (New York, N.Y.) 1995 (PubMed)
    Show all 4 references for 610691

  3. Human Polyclonal PYCARD Primary Antibody for WB - ABIN4281797 : Siraj, Hussain, Al-Rasheed, Ahmed, Bavi, Alsobhi, Al-Nuaim, Uddin, Al-Kuraya: Demethylation of TMS1 gene sensitizes thyroid cancer cells to TRAIL-induced apoptosis. in The Journal of clinical endocrinology and metabolism 2011 (PubMed)

  4. Human Monoclonal PYCARD Primary Antibody for FACS, IHC - ABIN4281806 : Peng, French, Tillman, Morgan, French: The inflammasome in alcoholic hepatitis: Its relationship with Mallory-Denk body formation. in Experimental and molecular pathology 2014 (PubMed)

  5. Human Polyclonal PYCARD Primary Antibody for IHC (p), IHC - ABIN257733 : Ohtsuka, Ryu, Minamishima, Macip, Sagara, Nakayama, Aaronson, Lee: ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway. in Nature cell biology 2004 (PubMed)

  6. Mouse (Murine) Polyclonal PYCARD Primary Antibody for WB - ABIN2780039 : Mariathasan, Newton, Monack, Vucic, French, Lee, Roose-Girma, Erickson, Dixit: Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. in Nature 2004 (PubMed)

More Antibodies against PYCARD Interaction Partners

Human PYD and CARD Domain Containing (PYCARD) interaction partners

  1. ASC Induces Apoptosis via Activation of Caspase-9 (show CASP9 Antibodies) by Enhancing Gap Junction-Mediated Intercellular Communication.(

  2. These data revealed that cross-linking of ASC(PYD) filaments via ASC(CARD) mediates the assembly of ASC foci.

  3. Down-regulation of mRNA expression was found in cases in which CASP8 (show CASP8 Antibodies), TMS1 (show SERINC3 Antibodies) and DAPK (show DAPK1 Antibodies) were hypermethylated.

  4. loss of ASC driven tumor development is counterbalanced in the identical cell by the inhibition of pro-tumorigenic inflammation in the tumor cell itself

  5. the deubiquitinating enzyme USP50 (show USP50 Antibodies) binds to the ASC protein and subsequently regulates the inflammasome signaling pathway.

  6. ASC self-associates and binds NLRP3 (show NLRP3 Antibodies) PYD through equivalent protein regions, with higher binding affinity for the latter. These regions are located at opposite sides of the protein allowing multimeric complex formation previously shown in ASC PYD fibril assemblies.

  7. Our data identify RIPK3 (show RIPK3 Antibodies) and the ASC inflammasome as key tumor suppressors in AML (show RUNX1 Antibodies).

  8. The role of the danger signals ASC and HMGB1 (show HMGB1 Antibodies) in the Fusobacterium nucleatum infection of gingival epithelial cells.

  9. Data show that NOD-like receptor signaling genes NOD2 (show NOD2 Antibodies), PYCARD, CARD6 (show CARD6 Antibodies), and IFI16 (show IFI16 Antibodies) are upregulated in psoriatic epidermis.

  10. The methylated status of ASC/TMS1 promoter had the potential applicability for clinical evaluation the prognosis of gastric cancer

Mouse (Murine) PYD and CARD Domain Containing (PYCARD) interaction partners

  1. Our data identify RIPK3 (show RIPK3 Antibodies) and the ASC (show STS Antibodies) inflammasome as key tumor suppressors in AML (show RUNX1 Antibodies).

  2. Data show that T cell-intrinsic PYD and CARD domain containing protein ASC is required for TH17-mediated experimental autoimmune encephalomyelitis (EAE).

  3. Data suggest that interleukin 22 (IL-22 (show IL22 Antibodies)) plays a pro-inflammatory/pathogenic role in the onset of antigen-induced arthritis (AIA) through apoptosis-associated speck-like Pycard protein (ASC (show STS Antibodies))-dependent stimulation of interleukin-1 beta (IL-1beta (show IL1B Antibodies)) production.

  4. report herein that lack of ASC (show STS Antibodies) does not confer preferential protection in response to P. aeruginosa acute infection and that ASC (show STS Antibodies)(-/-) mice are capable of producing robust amounts of IL-1beta (show IL1B Antibodies) comparable with C57BL/6 mice

  5. These data identify a novel non-canonical immunoregulatory function of NLRP3 (show NLRP3 Antibodies) and ASC (show STS Antibodies) in autoimmunity.

  6. a significant role for NLRP3 (show NLRP3 Antibodies) and ASC (show STS Antibodies) in prion (show PRNP Antibodies) pathogenesis

  7. ASC (show STS Antibodies)-driven caspase-1 (show CASP1 Antibodies) autoprocessing and speck formation are dispensable for the activation of caspase-1 (show CASP1 Antibodies) and the NLRP1b inflammasome.

  8. IKKalpha (show CHUK Antibodies) controls the inflammasome at the level of the adaptor molecule ASC (show STS Antibodies), which interacts with IKKalpha (show CHUK Antibodies) in the nucleus of resting macrophages in an IKKalpha (show CHUK Antibodies) kinase-dependent manner.

  9. Hypoxia-induced elevated right ventricular pressure and remodeling were attenuated in mice lacking the inflammasome adaptor protein ASC (show STS Antibodies), suggesting that inflammasomes play an important role in the pathogenesis of pulmonary hypertension.

  10. gene deficiency results in absence of IL-1beta (show IL1B Antibodies) maturation in the middle ear response to non-typeable Haemophilus influenza, and in reduction of both leukocyte infiltration and macrophage phagocytosis

PYCARD Antigen Profile

Antigen Summary

This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm\; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with PYCARD

  • PYD and CARD domain containing (PYCARD) antibody
  • PYD and CARD domain containing (Pycard) antibody
  • PYD and CARD domain containing (pycard) antibody
  • 9130417A21Rik antibody
  • Asc antibody
  • asc1 antibody
  • CARD5 antibody
  • masc antibody
  • TMS antibody
  • TMS-1 antibody
  • TMS1 antibody
  • TNS1 antibody
  • zAsc antibody
  • zgc:109874 antibody

Protein level used designations for PYCARD

apoptosis-associated speck-like protein containing a CARD , caspase recruitment domain-containing protein 5 , target of methylation-induced silencing 1 , PYD and CARD domain-containing protein

29108 Homo sapiens
66824 Mus musculus
282817 Rattus norvegicus
282846 Bos taurus
57923 Danio rerio
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