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anti-Human PYCARD Antibodies:
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Human Polyclonal PYCARD Primary Antibody for WB - ABIN610691
Auphan, DiDonato, Rosette, Helmberg, Karin: Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. in Science (New York, N.Y.) 1995
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Human Polyclonal PYCARD Primary Antibody for ICC, IF - ABIN4281803
Yao, Carlson, Sun, Ma, Wolf, Minei, Zang: Mitochondrial ROS Induces Cardiac Inflammation via a Pathway through mtDNA Damage in a Pneumonia-Related Sepsis Model. in PLoS ONE 2015
Show all 3 Pubmed References
Human Polyclonal PYCARD Primary Antibody for IHC (p), IHC - ABIN257733
Ohtsuka, Ryu, Minamishima, Macip, Sagara, Nakayama, Aaronson, Lee: ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway. in Nature cell biology 2004
Human Polyclonal PYCARD Primary Antibody for WB - ABIN4281797
Siraj, Hussain, Al-Rasheed, Ahmed, Bavi, Alsobhi, Al-Nuaim, Uddin, Al-Kuraya: Demethylation of TMS1 gene sensitizes thyroid cancer cells to TRAIL-induced apoptosis. in The Journal of clinical endocrinology and metabolism 2011
Human Polyclonal PYCARD Primary Antibody for IHC, IHC (fro) - ABIN4281795
Doitsh, Galloway, Geng, Yang, Monroe, Zepeda, Hunt, Hatano, Sowinski, Muñoz-Arias, Greene: Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection. in Nature 2014
Human PYCARD Primary Antibody for ELISA, WB - ABIN645848
Ansari, Dutta, Veettil, Dutta, Iqbal, Kumar, Roy, Chikoti, Singh, Chandran: Herpesvirus Genome Recognition Induced Acetylation of Nuclear IFI16 Is Essential for Its Cytoplasmic Translocation, Inflammasome and IFN-β Responses. in PLoS pathogens 2015
Human Monoclonal PYCARD Primary Antibody for FACS, IHC - ABIN4281806
Peng, French, Tillman, Morgan, French: The inflammasome in alcoholic hepatitis: Its relationship with Mallory-Denk body formation. in Experimental and molecular pathology 2014
ASC CpG methylation may prove to be a primary regulator of the pathogenesis of chronic inflammatory diseases such as heart failure.
besides its role in the inhibition of the NF-kappaB (show NFKB1 Antibodies) pathway, NLRC3 (show NLRC3 Antibodies) interferes with the assembly and activity of the NALP3 (show NLRP3 Antibodies) inflammasome complex by competing with ASC for pro-caspase-1 (show CASP1 Antibodies) binding
ASC Induces Apoptosis via Activation of Caspase-9 (show CASP9 Antibodies) by Enhancing Gap Junction-Mediated Intercellular Communication.(
These data revealed that cross-linking of ASC(PYD) filaments via ASC(CARD) mediates the assembly of ASC foci.
Down-regulation of mRNA expression was found in cases in which CASP8 (show CASP8 Antibodies), TMS1 (show SERINC3 Antibodies) and DAPK (show DAPK1 Antibodies) were hypermethylated.
loss of ASC driven tumor development is counterbalanced in the identical cell by the inhibition of pro-tumorigenic inflammation in the tumor cell itself
the deubiquitinating enzyme USP50 (show USP50 Antibodies) binds to the ASC protein and subsequently regulates the inflammasome signaling pathway.
ASC self-associates and binds NLRP3 (show NLRP3 Antibodies) PYD through equivalent protein regions, with higher binding affinity for the latter. These regions are located at opposite sides of the protein allowing multimeric complex formation previously shown in ASC PYD fibril assemblies.
Our data identify RIPK3 (show RIPK3 Antibodies) and the ASC inflammasome as key tumor suppressors in AML (show RUNX1 Antibodies).
The role of the danger signals ASC and HMGB1 (show HMGB1 Antibodies) in the Fusobacterium nucleatum infection of gingival epithelial cells.
these findings suggest that p205 (show GNB2L1 Antibodies) controls expression of Asc (show STS Antibodies) mRNA to regulate inflammasome responses. These findings expand on our understanding of immune-regulatory roles for the PYHIN protein family.
this study shows that ASC (show STS Antibodies)-dependent Inflammasomes do not shape the commensal gut (show GUSB Antibodies) microbiota composition
Our data identify RIPK3 (show RIPK3 Antibodies) and the ASC (show STS Antibodies) inflammasome as key tumor suppressors in AML (show RUNX1 Antibodies).
Data show that T cell-intrinsic PYD and CARD domain containing protein ASC is required for TH17-mediated experimental autoimmune encephalomyelitis (EAE).
Data suggest that interleukin 22 (IL-22 (show IL22 Antibodies)) plays a pro-inflammatory/pathogenic role in the onset of antigen-induced arthritis (AIA) through apoptosis-associated speck-like Pycard protein (ASC (show STS Antibodies))-dependent stimulation of interleukin-1 beta (IL-1beta (show IL1B Antibodies)) production.
report herein that lack of ASC (show STS Antibodies) does not confer preferential protection in response to P. aeruginosa acute infection and that ASC (show STS Antibodies)(-/-) mice are capable of producing robust amounts of IL-1beta (show IL1B Antibodies) comparable with C57BL/6 mice
These data identify a novel non-canonical immunoregulatory function of NLRP3 (show NLRP3 Antibodies) and ASC (show STS Antibodies) in autoimmunity.
a significant role for NLRP3 (show NLRP3 Antibodies) and ASC (show STS Antibodies) in prion (show PRNP Antibodies) pathogenesis
ASC (show STS Antibodies)-driven caspase-1 (show CASP1 Antibodies) autoprocessing and speck formation are dispensable for the activation of caspase-1 (show CASP1 Antibodies) and the NLRP1b inflammasome.
IKKalpha (show CHUK Antibodies) controls the inflammasome at the level of the adaptor molecule ASC (show STS Antibodies), which interacts with IKKalpha (show CHUK Antibodies) in the nucleus of resting macrophages in an IKKalpha (show CHUK Antibodies) kinase-dependent manner.
This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm\; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.
apoptosis-associated speck-like protein containing a CARD
, caspase recruitment domain-containing protein 5
, target of methylation-induced silencing 1
, PYD and CARD domain-containing protein