Browse our PYCARD Proteins (PYCARD)

Full name:
PYD and CARD Domain Containing Proteins (PYCARD)
On are 8 PYD and CARD Domain Containing (PYCARD) Proteins from 4 different suppliers available. Additionally we are shipping PYCARD Antibodies (154) and PYCARD Kits (8) and many more products for this protein. A total of 182 PYCARD products are currently listed.
9130417A21Rik, Asc, asc1, CARD5, masc, TMS, TMS-1, TMS1, TNS1, zAsc, zgc:109874
list all proteins Gene Name GeneID UniProt
Rat PYCARD PYCARD 282817  

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PYCARD Proteins (PYCARD) by Origin

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Top referenced PYCARD Proteins

  1. Human PYCARD Protein expressed in Wheat germ - ABIN1316968 : Shi, Wang, Li, Zhan, Tang, Fina, Su, Pratt, Bu, Hildebrand, Lyon, Scott, Quan, Sun, Russell, Arnett, Jurek, Chen, Kravchenko, Mathison, Moresco, Monson, Ulevitch, Beutler: NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component. in Nature immunology 2016 (PubMed)

More Proteins for PYCARD Interaction Partners

Human PYD and CARD Domain Containing (PYCARD) interaction partners

  1. besides its role in the inhibition of the NF-kappaB (show NFKB1 Proteins) pathway, NLRC3 interferes with the assembly and activity of the NALP3 (show NLRP3 Proteins) inflammasome complex by competing with ASC for pro-caspase-1 (show CASP1 Proteins) binding

  2. ASC Induces Apoptosis via Activation of Caspase-9 (show CASP9 Proteins) by Enhancing Gap Junction-Mediated Intercellular Communication.(

  3. These data revealed that cross-linking of ASC(PYD) filaments via ASC(CARD) mediates the assembly of ASC foci.

  4. Down-regulation of mRNA expression was found in cases in which CASP8 (show CASP8 Proteins), TMS1 (show SERINC3 Proteins) and DAPK (show DAPK1 Proteins) were hypermethylated.

  5. loss of ASC driven tumor development is counterbalanced in the identical cell by the inhibition of pro-tumorigenic inflammation in the tumor cell itself

  6. the deubiquitinating enzyme USP50 (show USP50 Proteins) binds to the ASC protein and subsequently regulates the inflammasome signaling pathway.

  7. ASC self-associates and binds NLRP3 (show NLRP3 Proteins) PYD through equivalent protein regions, with higher binding affinity for the latter. These regions are located at opposite sides of the protein allowing multimeric complex formation previously shown in ASC PYD fibril assemblies.

  8. Our data identify RIPK3 (show RIPK3 Proteins) and the ASC inflammasome as key tumor suppressors in AML (show RUNX1 Proteins).

  9. The role of the danger signals ASC and HMGB1 (show HMGB1 Proteins) in the Fusobacterium nucleatum infection of gingival epithelial cells.

  10. Data show that NOD-like receptor signaling genes NOD2, PYCARD, CARD6, and IFI16 (show IFI16 Proteins) are upregulated in psoriatic epidermis.

Mouse (Murine) PYD and CARD Domain Containing (PYCARD) interaction partners

  1. this study shows that ASC (show STS Proteins)-dependent Inflammasomes do not shape the commensal gut (show GUSB Proteins) microbiota composition

  2. Our data identify RIPK3 (show RIPK3 Proteins) and the ASC (show STS Proteins) inflammasome as key tumor suppressors in AML (show RUNX1 Proteins).

  3. Data show that T cell-intrinsic PYD and CARD domain containing protein ASC is required for TH17-mediated experimental autoimmune encephalomyelitis (EAE).

  4. Data suggest that interleukin 22 (IL-22 (show IL22 Proteins)) plays a pro-inflammatory/pathogenic role in the onset of antigen-induced arthritis (AIA) through apoptosis-associated speck-like Pycard protein (ASC (show STS Proteins))-dependent stimulation of interleukin-1 beta (IL-1beta (show IL1B Proteins)) production.

  5. report herein that lack of ASC (show STS Proteins) does not confer preferential protection in response to P. aeruginosa acute infection and that ASC (show STS Proteins)(-/-) mice are capable of producing robust amounts of IL-1beta (show IL1B Proteins) comparable with C57BL/6 mice

  6. These data identify a novel non-canonical immunoregulatory function of NLRP3 (show NLRP3 Proteins) and ASC (show STS Proteins) in autoimmunity.

  7. a significant role for NLRP3 (show NLRP3 Proteins) and ASC (show STS Proteins) in prion (show PRNP Proteins) pathogenesis

  8. ASC (show STS Proteins)-driven caspase-1 (show CASP1 Proteins) autoprocessing and speck formation are dispensable for the activation of caspase-1 (show CASP1 Proteins) and the NLRP1b inflammasome.

  9. IKKalpha (show CHUK Proteins) controls the inflammasome at the level of the adaptor molecule ASC (show STS Proteins), which interacts with IKKalpha (show CHUK Proteins) in the nucleus of resting macrophages in an IKKalpha (show CHUK Proteins) kinase-dependent manner.

  10. Hypoxia-induced elevated right ventricular pressure and remodeling were attenuated in mice lacking the inflammasome adaptor protein ASC (show STS Proteins), suggesting that inflammasomes play an important role in the pathogenesis of pulmonary hypertension.

PYCARD Protein Profile

Protein Summary

This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm\; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with PYCARD

  • PYD and CARD domain containing (PYCARD)
  • PYD and CARD domain containing (Pycard)
  • PYD and CARD domain containing (pycard)
  • 9130417A21Rik protein
  • Asc protein
  • asc1 protein
  • CARD5 protein
  • masc protein
  • TMS protein
  • TMS-1 protein
  • TMS1 protein
  • TNS1 protein
  • zAsc protein
  • zgc:109874 protein

Protein level used designations for PYCARD

apoptosis-associated speck-like protein containing a CARD , caspase recruitment domain-containing protein 5 , target of methylation-induced silencing 1 , PYD and CARD domain-containing protein

29108 Homo sapiens
66824 Mus musculus
282817 Rattus norvegicus
282846 Bos taurus
57923 Danio rerio
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