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mechanisms of interaction with flagellin (show FliC Proteins) and profilin (show PFN1 Proteins)
Data show that TLR11 expression is induced in astrocytes, neurons, and microglia in the immune response to T. gondii infection
TLR11 mediates innate immune function of male germ cells in response to T. gondii profilin (show PFN1 Proteins) and uropathogenic escherichia coli stimulations.
Biochemical experiments revealed that TLR11 and TLR12 (show Tlr12 Proteins) directly bind to Toxoplasma gondii profilin (show PFN1 Proteins) and are capable of forming a heterodimer complex.
Selective elimination of neutrophils in TLR11-deficient mice infected with Toxoplasma gondii results in acute susceptibility similar to that observed in IFN-gamma (show IFNG Proteins)-deficient mice.
While parasite RNA and DNA activate innate immune responses via TLR7 (show TLR7 Proteins) and TLR9 (show TLR9 Proteins), TLR11 and TLR12 (show Tlr12 Proteins) heterodimers are required for sensing and responding to Toxoplasma profilin (show PFN1 Proteins) infection.
a potentially important role for TLR11 in preventing murine intestinal infection and modulating antigen transportation in the gut (show GUSB Proteins) and imply an important role for various TLRs in cooperation with tight control of pathogens penetrating into Peyer patches.
association with UNC93B1 and the intracellular localization of TLRs are not unique features of nucleic acid-sensing TLRs but is also essential for TLR11-dependent recognition of T. gondii profilin (show PFN1 Proteins) and for host protection against this parasite
Data demonstrate that transcription of the Tlr11 gene is regulated through epithelium-specific transcription factors and IRF-8 (show IRF8 Proteins).
displays a distinct pattern of expression in macrophages and liver, kidney, and bladder epithelial cells; mice lacking TLR11 are highly susceptible to infection of the kidneys by uropathogenic bacteria
Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).