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Biochemical experiments revealed that TLR11 (show Tlr11 Proteins) and TLR12 directly bind to Toxoplasma gondii profilin (show PFN1 Proteins) and are capable of forming a heterodimer complex.
While parasite RNA and DNA activate innate immune responses via TLR7 (show TLR7 Proteins) and TLR9 (show TLR9 Proteins), TLR11 (show Tlr11 Proteins) and TLR12 heterodimers are required for sensing and responding to Toxoplasma profilin (show PFN1 Proteins) infection.
Recognition of profilin (show PFN1 Proteins) by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii.
Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Plays a role in preventing infection of internal organs of the urogenital system.