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Browse our CRTC2 Proteins (CRTC2)

Full name:
CREB Regulated Transcription Coactivator 2 Proteins (CRTC2)
On are 5 CREB Regulated Transcription Coactivator 2 (CRTC2) Proteins from 3 different suppliers available. Additionally we are shipping CRTC2 Antibodies (150) and many more products for this protein. A total of 169 CRTC2 products are currently listed.
4632407F12Rik, CRTC2, mTORC2, RGD1308903, TORC-2, Torc2
list all proteins Gene Name GeneID UniProt
CRTC2 200186 Q53ET0
CRTC2 74343 Q3U182
CRTC2 310615 Q3LRZ1

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CRTC2 Proteins (CRTC2) by Origin

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Human CREB Regulated Transcription Coactivator 2 (CRTC2) interaction partners

  1. critical pathophysiologic event in the evolution of HER2 (show ERBB2 Proteins)-amplified cancers is the loss of the input signals that normally drive TORC2 signaling, repositioning it under Akt (show AKT1 Proteins) dependency, and fundamentally altering the role of HER3 (show ERBB3 Proteins)

  2. Our results establish a role for CRTC2 as a lymphoma tumor suppressor gene

  3. In neuroblastoma (show ARHGEF16 Proteins), transcription of HIF2A (show EPAS1 Proteins) is strongly dependent on mTORC2.

  4. the high expression of CRTC2 and PROM1 may play an important role in the occurrence and hereditary, and also advance the potential pathways that integrate genetic variants in the development of NSCLC.

  5. The data from the current study demonstrated novel PROM1 and CRTC2 mutations, which could promote lung cancer development.

  6. These results clearly indicate that non-phosphorylated CRTC2 strongly enhances hepatitis b virus biosynthesis through inducing PGC1alpha expression.

  7. Phosphorylation of CRTC2 at its AMPK (show PRKAA1 Proteins) target site, Ser (show SIGLEC1 Proteins) 171, dictated its subcellular localization, and the activation of aromatase (show CYP19A1 Proteins) PII in preadipocytes.

  8. CRTC2 enhances CREB (show CREB1 Proteins) phosphorylation through an association with the protein arginine methyltransferase 5 (PRMT5 (show PRMT5 Proteins)).

  9. we found that overexpressed RIOK2 formed a complex with RIOK1 (show RIOK1 Proteins), mTor (show FRAP1 Proteins), and mTor (show FRAP1 Proteins)-complex-2(TORC2) components, and that overexpressed RIOK2 upregulated Akt (show AKT1 Proteins) signaling and promoted tumorigenesis

  10. TGFbeta (show TGFB1 Proteins)-stimulated Smad 3 (show SMAD3 Proteins) acts as a key node to instill a feedback loop between deptor (show DEPTOR Proteins) down-regulation and TORC1 (show CRTC1 Proteins)/2 activation in driving mesangial cell hypertrophy

Mouse (Murine) CREB Regulated Transcription Coactivator 2 (CRTC2) interaction partners

  1. we found that pharmacologically boosting either mTORC2 or actin polymerization enhances long-term memory

  2. mTORC2 has a central role in IFNgamma signaling and type II IFN responses

  3. CRTC2 promotes Th17 cell differentiation via stimulation of IL-17A (show IL17A Proteins) and IL-17F (show IL17F Proteins) expression by binding to CREB (show CREB1 Proteins) over both promoters. CRTC2-mutant mice have decreased Th17 cells, and they are protected from experimental autoimmune encephalitis.

  4. chronic increases in CRTC2 activity in the liver are indeed sufficient to promote hepatic insulin (show INS Proteins) resistance and to disrupt glucose homeostasis

  5. cAMP, SIK and CRTC mediate StAR expression through activation of individual StAR gene loci.

  6. our study demonstrates the existence of a direct crosstalk between mTORC2 and MST1 (show MST1 Proteins) that is critical for cardiac cell survival and growth.

  7. RICTOR/mTORC2 is important for interactions between vasculature, adipocytes, and brain to tune physiological outcomes, such as blood pressure and locomotor activity.

  8. CREB regulated transcription coactivator 2 (CRTC2) functions as a mediator of mTOR (show FRAP1 Proteins) signalling to modulate COPII-dependent SREBP1 (show SREBF1 Proteins) processing

  9. Our findings provide new insight into the role of mTORC2 in regulating dendritic cell function

  10. RICTOR depletion on lifespan is independent of the role of hepatic mTORC2 in promoting glucose tolerance.

CRTC2 Protein Profile

Protein Summary

This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5.

Alternative names and synonyms associated with CRTC2

  • CREB regulated transcription coactivator 2 (CRTC2)
  • CREB regulated transcription coactivator 2 (LOC100358960)
  • CREB regulated transcription coactivator 2 (Crtc2)
  • 4632407F12Rik protein
  • CRTC2 protein
  • mTORC2 protein
  • RGD1308903 protein
  • TORC-2 protein
  • Torc2 protein

Protein level used designations for CRTC2

CREB regulated transcription coactivator 2 , CREB-regulated transcription coactivator 2 , CREB-regulated transcription coactivator 2-like , transducer of regulated cAMP response element-binding protein (CREB) 2 , TORC-2 , transducer of CREB protein 2 , transducer of regulated cAMP response element-binding protein 2

612305 Canis lupus familiaris
715908 Macaca mulatta
100056571 Equus caballus
100151904 Sus scrofa
100358960 Oryctolagus cuniculus
100472270 Ailuropoda melanoleuca
100019951 Monodelphis domestica
100597840 Nomascus leucogenys
200186 Homo sapiens
74343 Mus musculus
310615 Rattus norvegicus
540959 Bos taurus
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