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Browse our CRTC2 Proteins (CRTC2)

Full name:
CREB Regulated Transcription Coactivator 2 Proteins (CRTC2)
On www.antibodies-online.com are 5 CREB Regulated Transcription Coactivator 2 (CRTC2) Proteins from 3 different suppliers available. Additionally we are shipping CRTC2 Antibodies (165) and many more products for this protein. A total of 184 CRTC2 products are currently listed.
Synonyms:
4632407F12Rik, CRTC2, mTORC2, RGD1308903, TORC-2, Torc2
list all proteins Gene Name GeneID UniProt
CRTC2 200186 Q53ET0
CRTC2 74343 Q3U182
CRTC2 310615 Q3LRZ1

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CRTC2 Proteins (CRTC2) by Origin

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More Proteins for CRTC2 Interaction Partners

Human CREB Regulated Transcription Coactivator 2 (CRTC2) interaction partners

  1. CRTC2 strongly enhances GR-induced transcriptional activity of glucocorticoid-responsive genes.

  2. Our results establish a role for CRTC2 as a lymphoma tumor suppressor gene

  3. the high expression of CRTC2 and PROM1 may play an important role in the occurrence and hereditary, and also advance the potential pathways that integrate genetic variants in the development of NSCLC.

  4. The data from the current study demonstrated novel PROM1 and CRTC2 mutations, which could promote lung cancer development.

  5. These results clearly indicate that non-phosphorylated CRTC2 strongly enhances hepatitis b virus biosynthesis through inducing PGC1alpha expression.

  6. Phosphorylation of CRTC2 at its AMPK (show PRKAA1 Proteins) target site, Ser (show SIGLEC1 Proteins) 171, dictated its subcellular localization, and the activation of aromatase (show CYP19A1 Proteins) PII in preadipocytes.

  7. CRTC2 enhances CREB (show CREB1 Proteins) phosphorylation through an association with the protein arginine methyltransferase 5 (PRMT5 (show PRMT5 Proteins)).

  8. Mechanism of CREB (show CREB1 Proteins) recognition and coactivation by the CREB (show CREB1 Proteins)-regulated transcriptional coactivator CRTC2

  9. The lipogenic effects of GIP (show GIP Proteins) in the presence of insulin (show INS Proteins) are therefore at least partially mediated by upregulation of adipocyte LPL (show LCP1 Proteins) gene transcription through a pathway involving PI3-K (show PIK3CA Proteins)/PKB (show AKT1 Proteins)/AMPK (show PRKAA1 Proteins)-dependent CREB (show CREB1 Proteins)/TORC2 activation.

  10. the association of Pin1 (show PIN1 Proteins) with CRTC2 to decrease the nuclear CBP.CRTC.CREB complex.

Mouse (Murine) CREB Regulated Transcription Coactivator 2 (CRTC2) interaction partners

  1. the protein expression of adipose tissue CRTC 2 was reduced in mice with a combined application of change to general diet and exercise. In addition, while the protein expressions of lipase (show LIPG Proteins) ATGL (show PNPLA2 Proteins) and HSL (show LIPE Proteins) were reduced in the mice fed with the high fat diet continually after obesity was induced

  2. CRTC2 promotes Th17 cell differentiation via stimulation of IL-17A (show IL17A Proteins) and IL-17F (show IL17F Proteins) expression by binding to CREB (show CREB1 Proteins) over both promoters. CRTC2-mutant mice have decreased Th17 cells, and they are protected from experimental autoimmune encephalitis.

  3. chronic increases in CRTC2 activity in the liver are indeed sufficient to promote hepatic insulin (show INS Proteins) resistance and to disrupt glucose homeostasis

  4. cAMP, SIK and CRTC mediate StAR expression through activation of individual StAR gene loci.

  5. RICTOR/mTORC2 is important for interactions between vasculature, adipocytes, and brain to tune physiological outcomes, such as blood pressure and locomotor activity.

  6. CREB regulated transcription coactivator 2 (CRTC2) functions as a mediator of mTOR (show FRAP1 Proteins) signalling to modulate COPII-dependent SREBP1 (show SREBF1 Proteins) processing

  7. Translational activation of CREB (show CREB1 Proteins) is caused by elevated phospho-elF2alpha (show EIF2S1 Proteins).

  8. CRTC2 mRNA levels down-regulation improves glucose control and other markers of metabolic function in experimental type 2 diabetes mellitus.

  9. PRMT6 (show PRMT6 Proteins) is involved in the regulation of hepatic glucose metabolism in a CRTC2-dependent manner.

  10. Crtc2-overexpressing mice have increased myofiber cross-sectional area, greater intramuscular triglycerides and glycogen (show GYS1 Proteins) content.

CRTC2 Protein Profile

Protein Summary

This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5.

Alternative names and synonyms associated with CRTC2

  • CREB regulated transcription coactivator 2 (CRTC2)
  • CREB regulated transcription coactivator 2 (LOC100358960)
  • CREB regulated transcription coactivator 2 (Crtc2)
  • 4632407F12Rik protein
  • CRTC2 protein
  • mTORC2 protein
  • RGD1308903 protein
  • TORC-2 protein
  • Torc2 protein

Protein level used designations for CRTC2

CREB regulated transcription coactivator 2 , CREB-regulated transcription coactivator 2 , CREB-regulated transcription coactivator 2-like , transducer of regulated cAMP response element-binding protein (CREB) 2 , TORC-2 , transducer of CREB protein 2 , transducer of regulated cAMP response element-binding protein 2

GENE ID SPECIES
612305 Canis lupus familiaris
715908 Macaca mulatta
100056571 Equus caballus
100151904 Sus scrofa
100358960 Oryctolagus cuniculus
100472270 Ailuropoda melanoleuca
100019951 Monodelphis domestica
100597840 Nomascus leucogenys
200186 Homo sapiens
74343 Mus musculus
310615 Rattus norvegicus
540959 Bos taurus
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