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critical pathophysiologic event in the evolution of HER2 (show ERBB2 Proteins)-amplified cancers is the loss of the input signals that normally drive TORC2 signaling, repositioning it under Akt (show AKT1 Proteins) dependency, and fundamentally altering the role of HER3 (show ERBB3 Proteins)
Our results establish a role for CRTC2 as a lymphoma tumor suppressor gene
In neuroblastoma (show ARHGEF16 Proteins), transcription of HIF2A (show EPAS1 Proteins) is strongly dependent on mTORC2.
the high expression of CRTC2 and PROM1 may play an important role in the occurrence and hereditary, and also advance the potential pathways that integrate genetic variants in the development of NSCLC.
The data from the current study demonstrated novel PROM1 and CRTC2 mutations, which could promote lung cancer development.
These results clearly indicate that non-phosphorylated CRTC2 strongly enhances hepatitis b virus biosynthesis through inducing PGC1alpha expression.
Phosphorylation of CRTC2 at its AMPK (show PRKAA1 Proteins) target site, Ser (show SIGLEC1 Proteins) 171, dictated its subcellular localization, and the activation of aromatase (show CYP19A1 Proteins) PII in preadipocytes.
CRTC2 enhances CREB (show CREB1 Proteins) phosphorylation through an association with the protein arginine methyltransferase 5 (PRMT5 (show PRMT5 Proteins)).
we found that overexpressed RIOK2 formed a complex with RIOK1 (show RIOK1 Proteins), mTor (show FRAP1 Proteins), and mTor (show FRAP1 Proteins)-complex-2(TORC2) components, and that overexpressed RIOK2 upregulated Akt (show AKT1 Proteins) signaling and promoted tumorigenesis
TGFbeta (show TGFB1 Proteins)-stimulated Smad 3 (show SMAD3 Proteins) acts as a key node to instill a feedback loop between deptor (show DEPTOR Proteins) down-regulation and TORC1 (show CRTC1 Proteins)/2 activation in driving mesangial cell hypertrophy
we found that pharmacologically boosting either mTORC2 or actin polymerization enhances long-term memory
mTORC2 has a central role in IFNgamma signaling and type II IFN responses
CRTC2 promotes Th17 cell differentiation via stimulation of IL-17A (show IL17A Proteins) and IL-17F (show IL17F Proteins) expression by binding to CREB (show CREB1 Proteins) over both promoters. CRTC2-mutant mice have decreased Th17 cells, and they are protected from experimental autoimmune encephalitis.
chronic increases in CRTC2 activity in the liver are indeed sufficient to promote hepatic insulin (show INS Proteins) resistance and to disrupt glucose homeostasis
cAMP, SIK and CRTC mediate StAR expression through activation of individual StAR gene loci.
our study demonstrates the existence of a direct crosstalk between mTORC2 and MST1 (show MST1 Proteins) that is critical for cardiac cell survival and growth.
RICTOR/mTORC2 is important for interactions between vasculature, adipocytes, and brain to tune physiological outcomes, such as blood pressure and locomotor activity.
CREB regulated transcription coactivator 2 (CRTC2) functions as a mediator of mTOR (show FRAP1 Proteins) signalling to modulate COPII-dependent SREBP1 (show SREBF1 Proteins) processing
Our findings provide new insight into the role of mTORC2 in regulating dendritic cell function
RICTOR depletion on lifespan is independent of the role of hepatic mTORC2 in promoting glucose tolerance.
This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5.
CREB regulated transcription coactivator 2
, CREB-regulated transcription coactivator 2
, CREB-regulated transcription coactivator 2-like
, transducer of regulated cAMP response element-binding protein (CREB) 2
, transducer of CREB protein 2
, transducer of regulated cAMP response element-binding protein 2