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CRTC2 strongly enhances GR-induced transcriptional activity of glucocorticoid-responsive genes.
Our results establish a role for CRTC2 as a lymphoma tumor suppressor gene
the high expression of CRTC2 and PROM1 may play an important role in the occurrence and hereditary, and also advance the potential pathways that integrate genetic variants in the development of NSCLC.
The data from the current study demonstrated novel PROM1 and CRTC2 mutations, which could promote lung cancer development.
These results clearly indicate that non-phosphorylated CRTC2 strongly enhances hepatitis b virus biosynthesis through inducing PGC1alpha expression.
Phosphorylation of CRTC2 at its AMPK (show PRKAA1 Proteins) target site, Ser (show SIGLEC1 Proteins) 171, dictated its subcellular localization, and the activation of aromatase (show CYP19A1 Proteins) PII in preadipocytes.
CRTC2 enhances CREB (show CREB1 Proteins) phosphorylation through an association with the protein arginine methyltransferase 5 (PRMT5 (show PRMT5 Proteins)).
Mechanism of CREB (show CREB1 Proteins) recognition and coactivation by the CREB (show CREB1 Proteins)-regulated transcriptional coactivator CRTC2
The lipogenic effects of GIP (show GIP Proteins) in the presence of insulin (show INS Proteins) are therefore at least partially mediated by upregulation of adipocyte LPL (show LCP1 Proteins) gene transcription through a pathway involving PI3-K (show PIK3CA Proteins)/PKB (show AKT1 Proteins)/AMPK (show PRKAA1 Proteins)-dependent CREB (show CREB1 Proteins)/TORC2 activation.
the association of Pin1 (show PIN1 Proteins) with CRTC2 to decrease the nuclear CBP.CRTC.CREB complex.
the protein expression of adipose tissue CRTC 2 was reduced in mice with a combined application of change to general diet and exercise. In addition, while the protein expressions of lipase (show LIPG Proteins) ATGL (show PNPLA2 Proteins) and HSL (show LIPE Proteins) were reduced in the mice fed with the high fat diet continually after obesity was induced
CRTC2 promotes Th17 cell differentiation via stimulation of IL-17A (show IL17A Proteins) and IL-17F (show IL17F Proteins) expression by binding to CREB (show CREB1 Proteins) over both promoters. CRTC2-mutant mice have decreased Th17 cells, and they are protected from experimental autoimmune encephalitis.
chronic increases in CRTC2 activity in the liver are indeed sufficient to promote hepatic insulin (show INS Proteins) resistance and to disrupt glucose homeostasis
cAMP, SIK and CRTC mediate StAR expression through activation of individual StAR gene loci.
RICTOR/mTORC2 is important for interactions between vasculature, adipocytes, and brain to tune physiological outcomes, such as blood pressure and locomotor activity.
CREB regulated transcription coactivator 2 (CRTC2) functions as a mediator of mTOR (show FRAP1 Proteins) signalling to modulate COPII-dependent SREBP1 (show SREBF1 Proteins) processing
Translational activation of CREB (show CREB1 Proteins) is caused by elevated phospho-elF2alpha (show EIF2S1 Proteins).
CRTC2 mRNA levels down-regulation improves glucose control and other markers of metabolic function in experimental type 2 diabetes mellitus.
PRMT6 (show PRMT6 Proteins) is involved in the regulation of hepatic glucose metabolism in a CRTC2-dependent manner.
Crtc2-overexpressing mice have increased myofiber cross-sectional area, greater intramuscular triglycerides and glycogen (show GYS1 Proteins) content.
This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5.
CREB regulated transcription coactivator 2
, CREB-regulated transcription coactivator 2
, CREB-regulated transcription coactivator 2-like
, transducer of regulated cAMP response element-binding protein (CREB) 2
, transducer of CREB protein 2
, transducer of regulated cAMP response element-binding protein 2