CRTC2 Products
(CREB Regulated Transcription Coactivator 2 (CRTC2))
Categories
This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2010].
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Featured CRTC2 Categories
CRTC2 Antibodies
High quality antibodies with extensive validation data.
CRTC2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CRTC2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Rat
Application
WB, ELISA, IF, FACS
Validations
- (6)
Cat. No.
ABIN5539499
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Monkey
Application
WB, ELISA, IHC, FACS, ICC
Validations
- (3)
- (4)
Cat. No.
ABIN969067
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, FACS
Validations
- (4)
- (2)
Cat. No.
ABIN745988
Quantity
100 μL
Datasheet
Datasheet
Recommended CRTC2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966120
Quantity
96 tests
Datasheet
Datasheet
Recommended CRTC2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1350407
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1350406
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
- (1)
Cat. No.
ABIN3092005
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our CRTC2 products
: "Keap1/Nrf2 pathway activation leads to a repressed hepatic gluconeogenic and lipogenic program in mice on a high-fat diet." in: Archives of biochemistry and biophysics, Vol. 591, pp. 57-65, (2016) (PubMed).: "Transcriptional regulation of autophagy by an FXR-CREB axis." in: Nature, Vol. 516, Issue 7529, pp. 108-11, (2015) (PubMed).
: "CRTC2 enhances HBV transcription and replication by inducing PGC1? expression." in: Virology journal, Vol. 11, Issue 1, pp. 30, (2014) (PubMed).
: "Uric acid-dependent inhibition of AMP kinase induces hepatic glucose production in diabetes and starvation: evolutionary implications of the uricase loss in hominids." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 28, Issue 8, pp. 3339-50, (2014) (PubMed).
: "BDNF and glucocorticoids regulate corticotrophin-releasing hormone (CRH) homeostasis in the hypothalamus." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 4, pp. 1305-10, (2012) (PubMed).
: "Involvement of transducer of regulated cAMP response element-binding protein activity on corticotropin releasing hormone transcription." in: Endocrinology, Vol. 151, Issue 3, pp. 1109-18, (2010) (PubMed).
: "TORC2, a coactivator of cAMP-response element-binding protein, promotes Epstein-Barr virus reactivation from latency through interaction with viral BZLF1 protein." in: The Journal of biological chemistry, Vol. 284, Issue 12, pp. 8033-41, (2009) (PubMed).
: "Breaking human cytomegalovirus major immediate-early gene silence by vasoactive intestinal peptide stimulation of the protein kinase A-CREB-TORC2 signaling cascade in human pluripotent embryonal ..." in: Journal of virology, Vol. 83, Issue 13, pp. 6391-403, (2009) (PubMed).
: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." in: Molecular systems biology, Vol. 3, pp. 89, (2007) (PubMed).
: "Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2." in: Nature, Vol. 449, Issue 7160, pp. 366-9, (2007) (PubMed).
Synonyms and alternative names related to CRTC2
CREB regulated transcription coactivator 2 (CRTC2), CREB regulated transcription coactivator 2 (Crtc2), 4632407F12Rik, CRTC2, mTORC2, RGD1308903, TORC-2, TORC2, Torc2Protein level used designations for CRTC2
- CREB regulated transcription coactivator 2
- CREB-regulated transcription coactivator 2
- CREB-regulated transcription coactivator 2-like
- transducer of regulated cAMP response element-binding protein (CREB) 2
- TORC-2
- transducer of CREB protein 2
- transducer of regulated cAMP response element-binding protein 2
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