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The missense p.74Ile>Met PRKACG mutation is associated with a marked defect in proplatelet formation and a low level in filamin A (show FLNA Proteins) in megakaryocytes.
Results suggest that PKA can negatively regulate ERalpha (show ESR1 Proteins), at least in part, through FoxH1 (show FOXH1 Proteins).
PKA-mediated phosphorylation of GPIbbeta at Ser (show SIGLEC1 Proteins)(166) negatively regulates VWF (show VWF Proteins) binding to GPIb-IX and is one of the mechanisms by which PKA mediates platelet inhibition
Results suggest that Cgamma and Calpha differ in structure and function in vitro, supporting the hypothesis that functionally different C-subunit isozymes could affect cAMP signal transduction downstream of protein kinase A activation.
In human primary pigmented nodular adrenocortical disease tissues, dexamethasone paradoxically stimulates cortisol release through a glucocorticoid receptor (show NR3C1 Proteins)-mediated effect on PKA catalytic subunits.
Findings show that PKIB (show PKIB Proteins) and PKA-C kinase can have critical functions of aggressive phenotype of PCs through Akt (show AKT1 Proteins) phosphorylation and that they should be a promising molecular target for PC treatment.
Cyclic AMP-dependent protein kinase (PKA) consists of two catalytic subunits and a regulatory subunit dimer. This gene encodes the gamma form of its catalytic subunit. The gene is intronless and is thought to be a retrotransposon derived from the gene for the alpha form of the PKA catalytic subunit.
, cAMP-dependent protein kinase catalytic subunit gamma
, serine(threonine) protein kinase
, protein kinase, cAMP-dependent, catalytic, gamma