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Details for Product No. ABIN1042623

C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (Extracellular Domain) antibody

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Antigen
Synonyms MER, RP38, c-mer, Eyk, Mer, Nyk, nmf12, rdy, C-EYK, MERTK, DKFZp469D2215, si:ch1073-268l12.2
Epitope
»Alternatives Extracellular Domain
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN1042623
Quantity 0.1 mL
Price
576.05 $   Plus shipping costs $45.00
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Availability Will be delivered in 5 to 6 Business Days
Immunogen Human MERTK extracellular domain
Myeloma Fusion Partners: FOX NY mouse myeloma
Clone A311F9G3
Isotype IgG1 kappa
Characteristics Mouse Anti-MERTK [A311F9G3]
Purification Protein G
Alternative Name MERTK
Molecular Weight 110 kDa
Gene ID 10461
OMIM 604705
UniProt Q12866
Research Area Neurology, Tyrosine Kinases
Application Notes Optimal antibody dilution should be determined by titration, however as a guideline use try WB: 1/1000.
Comment

In vertebrates, the photoreceptor cells are the basic sensory apparatus of the retina, primarily converting photon energy absorbed from light into neuronal signals. The photoreceptor proximal outer segments are synthesized daily by cell bodies, and outer segment tips are removed with a circadian rhythm. The shed outer segments are endocytosed by adjacent retinal pigment epithelial (RPE) cells, and are recycled to photoreceptors. The receptor tyrosine kinase MERTK protein is an approximately 120122 kDa (994 amino acids) protein expressed in RPEs. MERTK has a tyrosine kinase domain close to the Cterminal region and putative phosphorylation sites. Mutation of MERTK in the Royal College of Surgeons (RCS) rat results in defective phagocytosis of photoreceptor outer segments by the retinal pigment epithelium (RPE) and retinal degeneration, resulting in retinitis pigmentosa.

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Purified antibody containing PBS 0.1% sodium azide
Preservative Sodium azide
Product cited in: Graham, Dawson, Mullaney et al.: "Cloning and mRNA expression analysis of a novel human protooncogene, c-mer." in: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, Vol. 5, Issue 6, pp. 647-57, 1994 (PubMed).

Alternatives for antigen "C-Mer Proto-Oncogene Tyrosine Kinase (MERTK)", type "Antibodies"
Hosts (52), (15), (7), (2)
Reactivities (72), (27), (19), (3)
Applications (60), (33), (10), (10), (8), (7), (5), (5), (3), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (11), (6), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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