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+1 404 474 4654 |
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+1 888 205 9894 (TF) |
C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (Extracellular Domain) antibody
| Antigen | C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) |
| Synonyms | MER, RP38, c-mer, MGC133349, Eyk, Mer, Nyk, rdy, C-EYK, MERTK, DKFZp469D2215, si:ch1073-268l12.2 |
| Binding Site |
 Alternatives Extracellular Domain |
| Clonality | Monoclonal (A311F9G3) |
| Host |
Alternatives Mouse |
| Reactivity |
Alternatives Human |
| Conjugate |
Alternatives Un-conjugated |
| Application |
Alternatives Western Blotting (WB) |
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1 reference available |
| Catalog no. | ABIN1042623 |
| Quantity | 0.1ml (Variants) |
| Price | 411.05 $ Plus shipping costs $45.00 |
| Shipping to |
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| Availability | Will be delivered in 5 to 6 Business Days |
Additional Information
| Alternative name | MERTK |
| Immunogen | Mer |
| Format | Liquid |
| Isotype | IgG1 kappa |
| Clone | A311F9G3 |
| Description |
Myeloma/Fusion Partners: FOX NY mouse myeloma, Synonyms: c MER antibody,c mer proto oncogene tyrosine kinase antibody,cMER antibody,cmer protooncogene tyrosinekinase antibody,MER antibody,MER receptor tyrosine kinase antibody,MERK antibody,MERPEN antibody,Mertkantibody,MERTK_HUMAN antibody,MGC133349 antibody,Proto oncogene tyrosine protein kinase MER antibody,Protooncogene tyrosine protein kinase MER precursor antibody,Proto-oncogene c-Mer antibody,Receptor tyrosine kinaseMerTK antibody,STK kinase antibody,Tyrosine-protein kinase Mer antibody |
| Specificity | Human Mer. |
| Comments |
In vertebrates, the photoreceptor cells are the basic sensory apparatus of the retina, primarily converting photon energy absorbed from light into neuronal signals. The photoreceptor proximal outer segments are synthesized daily by cell bodies, and outer segment tips are removed with a circadian rhythm. The shed outer segments are endocytosed by adjacent retinal pigment epithelial (RPE) cells, and are recycled to photoreceptors. The receptor tyrosine kinase MERTK protein is an approximately 120122 kDa (994 amino acids) protein expressed in RPEs. MERTK has a tyrosine kinase domain close to the Cterminal region and putative phosphorylation sites. Mutation of MERTK in the Royal College of Surgeons (RCS) rat results in defective phagocytosis of photoreceptor outer segments by the retinal pigment epithelium (RPE) and retinal degeneration, resulting in retinitis pigmentosa. |
Application Details
| Application Notes | Optimal antibody dilution should be determined by titration, however as a guideline use at 1:1000 for western blot |
| Purification | Protein G purified |
| Buffer | PBS |
| Research Area | Cell Biology, Neurology, Signaling, Tyrosine Kinases |
| Restrictions | For Research Use only |
Publications
| Product |
Graham, Dawson, Mullaney et al.: "Cloning and mRNA expression analysis of a novel human protooncogene, c-mer." in: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, Vol. 5, Issue 6, pp. 647-57, 1994 (PubMed).
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Alternatives
| Hosts | Rabbit (34), Mouse (8), Goat (3), Rat (1) |
| Reactivities | Human (42), Mouse (Murine) (19), Rat (Rattus) (18) |
| Applications | Western Blotting (WB) (27), ELISA (17), Immunofluorescence (IF) (16), Immunoprecipitation (IP) (5), Immunohistochemistry (IHC) (4), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (4), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Flow Cytometry (FACS) (2), Immunoelectron Microscopy (IEM) (1) |
| Conjugates | Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1) |
| Epitopes | N-Term (4), AA 50-100 (2), C-Term (2), Extracellular Domain (2), AA 200-250 (1), AA 746-757 (1), Phosphospecific (1) |
2013 BioMed Central Research Awards
