C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (Extracellular Domain) antibody

Details for Product No. ABIN1042623
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Synonyms C-EYK, MERTK, DKFZp469D2215, si:ch1073-268l12.2, MER, RP38, c-mer, Eyk, Mer, Nyk, nmf12, rdy
Extracellular Domain
(37), (33), (12), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
(146), (27), (20), (2)
(100), (27), (21), (2)
Clonality (Clone)
Monoclonal ()
(8), (7), (7), (7), (6), (6), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(104), (84), (41), (13), (10), (7), (6), (6), (4), (3), (2), (2)
Pubmed 2 references available
Quantity 0.1 mL
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Immunogen Human MERTK extracellular domain
Clone A311F9G3
Isotype IgG1 kappa
Characteristics Myeloma fusion partners:
FOX NY mouse myeloma
Predicted molecular weight: 110 kDa
Purification Protein G
Alternative Name MERTK (MERTK Antibody Abstract)
Background Synonyms:
c MER antibody,c mer proto oncogene tyrosine kinase antibody,cMER antibody,cmer protooncogene tyrosinekinase antibody,MER antibody,MER receptor tyrosine kinase antibody,MERK antibody,MERPEN antibody,Mertkantibody,MERTK_HUMAN antibody,MGC133349 antibody,Proto oncogene tyrosine protein kinase MER antibody,Protooncogene tyrosine protein kinase MER precursor antibody,Proto-oncogene c-Mer antibody,Receptor tyrosine kinaseMerTK antibody,STK kinase antibody,Tyrosine-protein kinase Mer antibody
UniProt Q12866
Research Area Neurology, Tyrosine Kinases
Pathways RTK signaling
Application Notes Optimal antibody dilution should be determined by titration, however as a guideline use try, WB: 1/1000.

In vertebrates, the photoreceptor cells are the basic sensory apparatus of the retina, primarily converting photon energy absorbed from light into neuronal signals. The photoreceptor proximal outer segments are synthesized daily by cell bodies, and outer segment tips are removed with a circadian rhythm. The shed outer segments are endocytosed by adjacent retinal pigment epithelial (RPE) cells, and are recycled to photoreceptors. The receptor tyrosine kinase MERTK protein is an approximately 120122 kDa (994 amino acids) protein expressed in RPEs. MERTK has a tyrosine kinase domain close to the Cterminal region and putative phosphorylation sites. Mutation of MERTK in the Royal College of Surgeons (RCS) rat results in defective phagocytosis of photoreceptor outer segments by the retinal pigment epithelium (RPE) and retinal degeneration, resulting in retinitis pigmentosa.

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer PBS, 0.1 % sodium azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Image no. 1 for anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (Extracellular Domain) antibody (ABIN1042623) anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (Extracellular Domain) antibody
Product cited in: Graham, Salzberg, Kurtzberg et al.: "Ectopic expression of the proto-oncogene Mer in pediatric T-cell acute lymphoblastic leukemia." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 12, Issue 9, pp. 2662-9, 2006 (PubMed).

Background publications Graham, Dawson, Mullaney et al.: "Cloning and mRNA expression analysis of a novel human protooncogene, c-mer." in: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, Vol. 5, Issue 6, pp. 647-57, 1994 (PubMed).

Validation Images
Catalog No. ABIN1042623
$ 480.04
Plus shipping costs $45.00
0.1 mL
$ 480.04

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