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Details for Product No. ABIN1105360

Amyloid beta (Abeta) (AA 1-16), (N-Term) antibody

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Synonyms aaa, abeta, abpp, ad1, appi, ctfgamma, cvap, pn2, APP, ABPP
»Alternatives AA 1-16, N-Term
»Alternatives Human, Mouse (Murine)
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
»Alternatives Un-conjugated
»Alternatives Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN1105360
Quantity 0.1 mg
346.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Synthetic amyloid beta peptide corresponding to amino acids 1-16 of human amyloid beta
Clone 2C8
Isotype IgG2b
Specificity This antibody reacts with synthetic beta-amyloid (1-40) and (1-42) on Western blot. This antibody does not react with recombinant APP (601-744). Thus this antibody thought to recognize N-terminal of Abeta (40) and Abeta (42) specifically.
Purification Protein-A Sepharose
Alternative Name Amyloid beta
Background Alzheimer’s disease (AD) is the most common form of dementia in the elderly. The neuropathological hallmarks are neurofibrillary tangles and senile plaques. The major protein component of the plaques is a 39-42 amino acid peptide (ß-amyloid/Aß). Aß occurs in two predominant forms with different COOH-termini, Aß 40 and Aß 42, and overproduction of Aß 42 has been suggested to be the cause of familial early-onset AD. Aß generation depends on proteolytic cleavage of the amyloid precursor protein (APP) by two unknown proteases: ß-secretase and gamma-secretase. Recent study suggested that a transmembrane aspartic protease, termed beta-site APP-cleaving enzyme (BACE), functionally acts as the ß-secretase. This antibody recognizes N-terminal of Aß 40 and Aß 42 specifically.
Alternate names: Amyloid beta peptide
Research Area Neurology, Alzheimer's Disease
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 50% glycerol, pH 7.2, without preservatives
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store (in aliquots) at -20 °C.
Expiry Date 12 months
Background publications Saito, Pietromonaco, Loo et al.: "Complete cloning and sequencing of rat gp330/\megalin,\" a distinctive member of the low density lipoprotein receptor gene family."" in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 21, pp. 9725-9, 1994 (PubMed).

Wang, Malmberg, Ek et al.: "Swine dust induces cytokine secretion from human epithelial cells and alveolar macrophages." in: Clinical and experimental immunology, Vol. 115, Issue 1, pp. 6-12, 1999 (PubMed).

Vassar, Bennett, Babu-Khan et al.: "Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE." in: Science (New York, N.Y.), Vol. 286, Issue 5440, pp. 735-41, 1999 (PubMed).

Alternatives for antigen "Amyloid beta (Abeta)", type "Antibodies"
Hosts (137), (78), (3)
Reactivities (183), (36), (20), (2), (1), (1)
Applications (145), (141), (57), (50), (40), (38), (30), (11), (5), (4), (2), (1), (1), (1)
Conjugates (13), (3)
Epitopes (55), (41), (26), (15), (9), (6), (6), (5), (4), (3), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)