Bcl-2 antibody (PE)
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- Target See all Bcl-2 (BCL2) Antibodies
- Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))
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Reactivity
- Human, Mouse, Rat
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This Bcl-2 antibody is conjugated to PE
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Application
- Flow Cytometry (FACS)
- Specificity
- This antibody reacts with Bcl-2.
- Cross-Reactivity (Details)
- Species reactivity (tested):Human, mouse, rat
- Purification
- Protein A agarose
- Immunogen
- Recombinant rat Bcl-2beta
- Clone
- 83-8B
- Isotype
- IgG1
- Top Product
- Discover our top product BCL2 Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS, 0.09 % NaN3, 1 % BSA
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- Store at 2 - 8 °C.
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- Target
- Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))
- Alternative Name
- Bcl-2 (BCL2 Products)
- Background
- The Bcl-2 related genes can inhibit (Bcl-XL and Mcl-1) or induce (Bax, Bcl-Xs, Bag and Bad) apoptosis in several systems. Bad was identified as a Bcl-2 interacting protein using a yeast two hybrid screening and λ expression cloning. It has homology to Bcl-2 within the Bcl-2 homolog domains 1 and 2 (BH1 and BH2). In mammalian cells, Bad selectively heterodimerizes with Bcl-XL as well as Bcl-2, but not with other Bcl-2 family members (Bax, Bcl-Xs, Mcl-1 and A1). When Bad heterodimerized with Bcl-XL, it displaced Bax from Bcl-XL and promoted cell death.Synonyms: Apoptosis regulator Bcl-2, B-Cell CLL/lymphoma 2, BCL2, Bcl-2 alpha
- Gene ID
- 24224
- NCBI Accession
- NP_058689
- UniProt
- P49950
- Pathways
- MAPK Signaling, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagy, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling
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