Checkpoint Kinase 1 (CHEK1) antibody

Details for Product No. ABIN1106682
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Antigen
Synonyms An08g10320, AO090003000441, CHK1, chk1, C85740, Chk1, rad27, id:ibd2720, zgc:56093, CHEK1
Reactivity
Human, Mouse (Murine)
(404), (132), (125), (36), (26), (26), (14), (4), (3), (2), (2), (2), (1)
Host
Mouse
(357), (39), (11), (7)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(9), (9), (9), (5), (5), (5), (5), (5), (5), (5), (5), (4), (4), (4)
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
(318), (156), (101), (59), (54), (50), (22), (21), (16), (11), (6), (4), (1), (1)
Pubmed 1 reference available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN1106682
308.00 $
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Clone 2G1D5
Isotype IgG1
Cross-Reactivity (Details) Species reactivity (tested):Human, Mouse.
Purification Purified
Alternative Name CHK1
Background CHK1, also known as CHEK1, it is a kinase that phosphorylates cdc25, an important phosphatase in cell cycle control, particularly for entry into mitosis. Cdc25, when phosphorylated on serine 216 by chk1 becomes bound by an adaptor protein in the cytoplasm. Therefore it is inhibited from removing the inhibiting phosphate from MPF (mitotic/maturation promoting factor) added by Wee1. Consequently, a cell is prevented from entering mitosis. Chk1 can also phosphorylate p53 at Ser20 in vitro.Synonyms: CHEK-1, CHEK1, CHK1 checkpoint homolog, Serine/threonine-protein kinase Chk1
Molecular Weight 56 kDa
Gene ID 1111
Research Area Kinases/Phosphatases, Cell Cycle
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer PBS, 0.03 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Supplier Images
anti-Checkpoint Kinase 1 (CHEK1) antibody anti-Checkpoint Kinase 1 (CHEK1) antibody
anti-Checkpoint Kinase 1 (CHEK1) antibody (2) anti-Checkpoint Kinase 1 (CHEK1) antibody (Image 2)
Background publications Matsuoka, Huang, Elledge: "Linkage of ATM to cell cycle regulation by the Chk2 protein kinase." in: Science (New York, N.Y.), Vol. 282, Issue 5395, pp. 1893-7, 1998 (PubMed).

Validation Images
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