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Semaphorin 7A, GPI Membrane Anchor (John Milton Hagen Blood Group) (SEMA7A) antibody

Details for Product No. ABIN110773
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Antigen
Synonyms 2900057C09Rik, CDw108, H-Sema-L, M-Sema-L, Semal, CD108, H-SEMA-K1, JMH, SEMAK1, SEMAL
Reactivity
Human
(55), (24), (20), (17), (17)
Host
Mouse
(29), (25), (2), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(7), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunoprecipitation (IP), Western Blotting (WB), Flow Cytometry (FACS)
(36), (35), (15), (14), (12), (5), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN110773
308.00 $
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Immunogen HPB-ALL human T cell line
Clone MEM-150
Isotype IgM
Specificity The antibody reacts with CD108 (JMH blood group antigen), a 80 kDa GPI-anchored glycoprotein expressed on various cell types including erythrocytes, lymphoblasts, at low levels it is present on circulating lymphocytes. Species Reactivity: Tested: Human
Purification Ion exchange chromatography
Purity > 95 % (by SDS-PAGE)
Alternative Name CD108 / SEMA7A
Background CD108 (Sema7A) is a GPI-anchored semaphorin family member, which enhances central and peripheral axonal growth and is required for proper axon track formation during ebryogenesis. CD108 also regulates osteoclast differentiation and pre-osteoblastic cell migration, and in immune system affects cell proliferation, chemotaxis and cytokine release. On erythrocytes CD108 defines the JMH (John-Milton-Hagen) human blood group. CD108 signalizes through its receptors plexin C1 and b1 integrins.
Alternate names: JMH blood group antigen, John-Milton-Hargen human blood group Ag, SEMAL, Semaphorin-7A, Semaphorin-K1, Semaphorin-L
Gene ID 8482
NCBI Accession NP_001139501.1
UniProt O75326
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow Cytometry. Immunoprecipitation. Western Blotting under non reducing conditions. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing. Dilute only prior to immediate use
Storage 4 °C/-20 °C
Storage Comment Store the antibody (undiluted) at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Mudad, Rao, Angelisova et al.: "Evidence that CDw108 membrane protein bears the JMH blood group antigen." in: Transfusion, Vol. 35, Issue 7, pp. 566-70, 1995 (PubMed).

Pasterkamp, Peschon, Spriggs et al.: "Semaphorin 7A promotes axon outgrowth through integrins and MAPKs." in: Nature, Vol. 424, Issue 6947, pp. 398-405, 2003 (PubMed).

Delorme, Saltel, Bonnelye et al.: "Expression and function of semaphorin 7A in bone cells." in: Biology of the cell / under the auspices of the European Cell Biology Organization, Vol. 97, Issue 7, pp. 589-97, 2005 (PubMed).

Suzuki, Okuno, Yamamoto et al.: "Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin." in: Nature, Vol. 446, Issue 7136, pp. 680-4, 2007 (PubMed).

Pasterkamp, Kolk, Hellemons et al.: "Expression patterns of semaphorin7A and plexinC1 during rat neural development suggest roles in axon guidance and neuronal migration." in: BMC developmental biology, Vol. 7, pp. 98, 2007 (PubMed).

Validation Images
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