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Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 4 (MLLT4) (AA 1814-1829) antibody

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Synonyms MLLT4, af-6, af6, si:ch211-278j12.1, AF6, RP3-431P23.3, 5033403D15Rik, Af-6, Afadin, Gm314, I-afadin, S-afadin, Af6
AA 1814-1829
(8), (6), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
(36), (18), (15), (2), (2)
(34), (2), (2)
Clonality (Clone)
Monoclonal ()
Enzyme Immunoassay (EIA), Immunoprecipitation (IP), Western Blotting (WB)
(25), (15), (10), (8), (5), (4), (3), (3), (1)
Pubmed 2 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen Peptide 1814-1829 aa of rat l-afadin
Clone 3
Isotype IgG1
Specificity This antibody detects L-Afadin.
Cross-Reactivity (Details) Species reactivity (tested):Human, mouse, rat, dog
Purification Protein G
Alternative Name MLLT4 / AF6 / Afadin (MLLT4 Antibody Abstract)
Background Afadin is an actin filament-binding protein that is involved in cell-cell adherens junctions (AJs) which directly interacts with the alpha herpus virus receptor, a member of the immunoglobulin supergene family. Afadin is colocalized with nectin at cadherin-based cell-cell adherence junctions in various tissues and cell lines. L-Afadin has been isolated as an F-actin-binding protein from rat brain. L-afadin is ubiquitously expressed and specifically localized at zonula adherens (ZA) in epithelial cells and at cell-cell adherens junctions (AJs) in non-epithelial cells. L-afadin has a splice variant, named small intestine absorptive afadin (s-afadin) which is abundantly expressed in neural tissue.Synonyms: Myeloid/lymphoid Or Mixed-lineage Leukemia Translocated To 4, Protein AF-6
Gene ID 26955
NCBI Accession NP_037349
UniProt O35889
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 2 - 8 °C.
Background publications Takahashi, Nakanishi, Miyahara et al.: "Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with Afadin, a PDZ domain-containing protein." in: The Journal of cell biology, Vol. 145, Issue 3, pp. 539-49, 1999 (PubMed).

Sakisaka, Nakanishi, Takahashi et al.: "Different behavior of l-afadin and neurabin-II during the formation and destruction of cell-cell adherens junction." in: Oncogene, Vol. 18, Issue 8, pp. 1609-17, 1999 (PubMed).

Catalog No. ABIN1108256
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