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Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 4 (MLLT4) (AA 1814-1829) antibody

Details for Product No. ABIN1108256, Supplier: Log in to see
Antigen
  • MLLT4
  • af-6
  • af6
  • si:ch211-278j12.1
  • AF6
  • RP3-431P23.3
  • 5033403D15Rik
  • Af-6
  • Afadin
  • Gm314
  • I-afadin
  • S-afadin
  • Af6
Epitope
AA 1814-1829
6
6
2
2
2
1
1
1
1
Reactivity
Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
35
16
15
2
2
Host
Mouse
31
2
2
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
2
Application
Enzyme Immunoassay (EIA), Immunoprecipitation (IP), Western Blotting (WB)
23
14
9
7
4
3
3
1
1
Supplier
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Immunogen Peptide 1814-1829 aa of rat l-afadin
Clone 3
Isotype IgG1
Specificity This antibody detects L-Afadin.
Cross-Reactivity (Details) Species reactivity (tested):Human, mouse, rat, dog
Purification Protein G
Alternative Name MLLT4 / AF6 / Afadin (MLLT4 Antibody Abstract)
Background Afadin is an actin filament-binding protein that is involved in cell-cell adherens junctions (AJs) which directly interacts with the alpha herpus virus receptor, a member of the immunoglobulin supergene family. Afadin is colocalized with nectin at cadherin-based cell-cell adherence junctions in various tissues and cell lines. L-Afadin has been isolated as an F-actin-binding protein from rat brain. L-afadin is ubiquitously expressed and specifically localized at zonula adherens (ZA) in epithelial cells and at cell-cell adherens junctions (AJs) in non-epithelial cells. L-afadin has a splice variant, named small intestine absorptive afadin (s-afadin) which is abundantly expressed in neural tissue.Synonyms: Myeloid/lymphoid Or Mixed-lineage Leukemia Translocated To 4, Protein AF-6
Gene ID 26955
NCBI Accession NP_037349
UniProt O35889
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 2 - 8 °C.
Background publications Takahashi, Nakanishi, Miyahara et al.: "Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with Afadin, a PDZ domain-containing protein." in: The Journal of cell biology, Vol. 145, Issue 3, pp. 539-49, 1999 (PubMed).

Sakisaka, Nakanishi, Takahashi et al.: "Different behavior of l-afadin and neurabin-II during the formation and destruction of cell-cell adherens junction." in: Oncogene, Vol. 18, Issue 8, pp. 1609-17, 1999 (PubMed).