Afadin Products
(Afadin (MLLT4))
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This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t(6\;11)(q27\;q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized.[provided by RefSeq, May 2011].
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Afadin Antibodies
High quality antibodies with extensive validation data.
Recommended Afadin Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (2)
Cat. No.
ABIN7143570
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7242503
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Bat, Cow, Dog, Human, Monkey, Rat
Application
WB
Validations
- (1)
Cat. No.
ABIN204949
Quantity
100 μL
Datasheet
Datasheet
Recommended Afadin Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN5777013
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our Afadin products
: "Concomitant binding of Afadin to LGN and F-actin directs planar spindle orientation." in: Nature structural & molecular biology, Vol. 23, Issue 2, pp. 155-63, (2016) (PubMed).: "Large-scale characterization of HeLa cell nuclear phosphoproteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 33, pp. 12130-5, (2004) (PubMed).
: "The DNA sequence and analysis of human chromosome 6. ..." in: Nature, Vol. 425, Issue 6960, pp. 805-11, (2003) (PubMed).
: "Cingulin contains globular and coiled-coil domains and interacts with ZO-1, ZO-2, ZO-3, and myosin." in: The Journal of cell biology, Vol. 147, Issue 7, pp. 1569-82, (2000) (PubMed).
: "Junctional adhesion molecule interacts with the PDZ domain-containing proteins AF-6 and ZO-1." in: The Journal of biological chemistry, Vol. 275, Issue 36, pp. 27979-88, (2000) (PubMed).
: "The junction-associated protein AF-6 interacts and clusters with specific Eph receptor tyrosine kinases at specialized sites of cell-cell contact in the brain." in: The Journal of cell biology, Vol. 144, Issue 2, pp. 361-71, (1999) (PubMed).
: "Identification of AF-6 and canoe as putative targets for Ras." in: The Journal of biological chemistry, Vol. 271, Issue 2, pp. 607-10, (1996) (PubMed).
: "Cloning of the ALL-1 fusion partner, the AF-6 gene, involved in acute myeloid leukemias with the t(6;11) chromosome translocation." in: Cancer research, Vol. 53, Issue 23, pp. 5624-8, (1994) (PubMed).
Synonyms and alternative names related to Afadin
afadin, adherens junction formation factor (AFDN), afadin, adherens junction formation factor L homeolog (afdn.L), afadin, adherens junction formation factor a (afdna), afadin (LOC589923), afadin (LOC100177180), afadin, adherens junction formation factor (afdn), afadin, adherens junction formation factor (Afdn), 5033403D15Rik, af-6, Af-6, af6, AF6, Af6, Afadin, Gm314, I-afadin, MLLT4, RP3-431P23.3, S-afadin, si:ch211-278j12.1Protein level used designations for Afadin
- myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
- afadin-like
- ALL1-fused gene from chromosome 6 protein
- afadin
- protein AF-6
- myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog
- protein Af-6
- myeloid/lymphoid or mixed-lineage leukemia 4
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