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Details for Product No. ABIN112142

Cyclin-Dependent Kinase 4 (CDK4) antibody

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Antigen
Synonyms	CMM3, PSK-J3, Crk3, 8-6, CDK4, CDK4/6, CG5072, Cdk4/6, DmCdk4, Dmel\\CG5072, Pk53C, Pk?7, cdk, cdk4, cdk4/6, dCdk4, l(2)05428, l(2)0671, l(2)k06503, l(2)s4639, l(2)sh0671, zgc:153726
Reactivity	Alternatives Human, Mouse (Murine), Pig (Porcine), Rat (Rattus) (159), (60), (48), (19), (14), (3), (1)
Host	Alternatives Mouse (82), (77), (4), (3), (1)
Clonality (Clone)	Monoclonal ()
Conjugate	Alternatives Un-conjugated (4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application	Alternatives Immunoprecipitation (IP), Western Blotting (WB) (149), (60), (44), (43), (16), (14), (10), (10), (8), (8), (5), (5), (2), (1), (1), (1)
	1 reference available

Catalog no.	ABIN112142
Quantity	50 µg
Price	335.50 $ Plus shipping costs $45.00

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Availability	Will be delivered in 6 to 8 Business Days

Product details

Alternative Name	CDK4
Background	Cdk4 is a member of the Ser/Thr protein kinase family. It is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. Cdk4 is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1/S phase, which is controlled by the regulatory subunits D type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). The mutations in this gene as well as its related proteins including D type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Two alternatively spliced variants, and multiple polyadenylation sites of this gene have been reported. Alternate names: Cell division protein kinase 4, Cyclin-dependent kinase 4, PSK-J3
Gene ID	1019
NCBI Accession	NP_000066.1
UniProt	P11802
Research Area	Cell Cycle

Alternatives for antigen "Cyclin-Dependent Kinase 4 (CDK4)", type "Antibodies"

Immunogen	Human recombinant full-length cdk4 polypeptide
Clone	DCS-35
Isotype	IgG1
Specificity	This antibody reacts specifically with cdk4 protein present predominantly in G1 phase of cell cycle, it does not cross-react with cyclins. Especially suitable for immunoprecipitation, mab DCS-35 precipitates the cdk4/cyclin complex.
Purification	Protein A affinity chromatography

Application Notes	Immunoprecipitation: 1: 3 - 1: 10, 1 - 4 h at RT or overnight at 2-8C. Western Blot. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions	For Research Use only

Format	Lyophilized
Reconstitution	Restore in 1 mL dist. water
Buffer	PBS buffer, pH 7.4 containing 0.09 % Sodium azide, 0.5% BSA
Preservative	Sodium azide
Handling Advice	Avoid repeated freezing and thawing.
Storage	4 °C/-20 °C
Storage Comment	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date	12 months

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