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ACTA2 / Aortic Smooth Muscle Actin (N-Term) antibody

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(11), (1), (1)
Chicken, Cow (Bovine), Human, Mouse (Murine), Rabbit, Rat (Rattus)
(18), (11), (11), (8), (8), (7), (5), (1), (1), (1)
(9), (7), (2)
Clonality (Clone)
Monoclonal ()
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(16), (10), (7), (6), (2), (2), (1)
Pubmed 2 references available
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Quantity 0.5 mL
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Immunogen N-terminal decapeptide of alpha-smooth muscle Actin
Clone 1A4-asm-1
Isotype IgG2a
Specificity This antibody is specific to alpha-smooth isoform of actin. It reacts with smooth muscle cells of vessels and different parenchymes. The antibody does not cross-react with beta and gamma-cytoplasmic, alpha-sarcomeric and alpha-myocardial actin isoforms.
Cellular Localization: Cytoplasmic.
Purification Purified
Background Smooth muscle actin is expressed in normal smooth muscle and in myoepithelial cells, and also in tumours derived from these cells. Actins are involved in maintaining the structure and integrity of a cell, as well as cell motility. They are highly conserved proteins and make up the majority of the contractile apparatus. To date, six different actin isoforms have been described.Synonyms: ACTSA, ACTVS, Alpha-actin-2, Cell growth-inhibiting gene 46 protein
Gene ID 59
NCBI Accession NP_001135417
UniProt P62736
Application Notes Immunohistochemistry on Formalin Fixed Paraffin Embedded Sections: Use Actin antibodyat 1/25-1/50 dilution in an ABC method for 30 minutes at room temperature. Recommended Positive Control: Leiomyoma.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Supplier Images
Immunohistochemistry (IHC) image for anti-ACTA2 / Aortic Smooth Muscle Actin (N-Term) antibody (ABIN114405) Formalin fixed paraffin embedded human leiomyoma stained with Smooth Muscle Actin ant...
Background publications Skalli, Pelte, Peclet et al.: "Alpha-smooth muscle actin, a differentiation marker of smooth muscle cells, is present in microfilamentous bundles of pericytes." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 37, Issue 3, pp. 315-21, 1989 (PubMed).

Skalli, Schürch, Seemayer et al.: "Myofibroblasts from diverse pathologic settings are heterogeneous in their content of actin isoforms and intermediate filament proteins." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 60, Issue 2, pp. 275-85, 1989 (PubMed).

Catalog No. ABIN114405
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